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Quantitative differentiation of thoracolumbar transitional vertebrae : possible embryological origins and associations with other anomalies in the vertebral column
Thesis (PhD (Anatomy))--University of Pretoria, 2021.
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University of Pretoria
2022
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| _version_ | 1867613715303497728 |
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| access_status_str | Open Access |
| author2 | Keough, Natalie |
| author_browse | Keough, Natalie |
| author_facet | Keough, Natalie |
| collection | Thesis |
| dc_rights_str_mv | © 2022 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Thesis (PhD (Anatomy))--University of Pretoria, 2021. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/83869 |
| institution | University of Pretoria (South Africa) |
| last_indexed | 2026-06-10T12:40:32.922Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/83869 Quantitative differentiation of thoracolumbar transitional vertebrae : possible embryological origins and associations with other anomalies in the vertebral column Keough, Natalie annelidupi@gmail.com Van Schoor, Albert-Neels Wessels, Quenton Du Plessis, Anneli Merle UCTD Quantitative differentiation Thesis (PhD (Anatomy))--University of Pretoria, 2021. INTRODUCTION: Transitional vertebrae result from overlapping developmental fields in the spine and can be located at any regional junction in the vertebral column. Consequently, transitional vertebrae retain features from the two respective adjacent regions. Based on the current literature, a need to further investigate TLTV with regards to repeatable differentiation, classification and clinical significance had been identified. MATERIALS AND METHODS: Therefore, this project aimed to identify vertebral anomalies and to determine whether TLTV can be quantitatively differentiated from thoracic and lumbar vertebrae using skeletal remains from Pretoria and the Western Cape of South Africa (n=287). This was achieved by measuring the superior zygapophyseal facet angle. This project also evaluated whether the measuring tool can be applied to living persons. Therefore this study additionally aimed to evaluate whether measurements can be used to differentiate vertebrae at the thoracolumbar junction using CT scans (n=175) representative of the Windhoek population in Namibia. This study also aimed to evaluate whether associations exist among congenital malformations of the spine and to explore the embryological events that lead to the formation of various anomalies in the spine. RESULTS: The results show that the prevalence of TLTV ranges between 7.5% (Windhoek), 30% (Western Cape) and 33.2% (Pretoria) in the reference samples. The results also clearly demonstrate that each vertebral type (thoracic, lumbar, TLTV) falls into separate distributions and confidence intervals. The results show that the mean angles and confidence intervals in skeletal remains for T12 is 189 ±9.5o (CI: 188o-190o), 110.6o ±7.88 (CI: 109.7o - 111.6o) for L1, and 137o ± 24.11 (CI: 133.5o - 140.5o) for TLTV. The mean confidence interval in CT-scans for T12 is 182.8 ± 10.4o (CI: 181.6o-183.9o), 112.3 ± 7.27o (CI: 111.5o-113o) for L1, and 136 ± 23.18o (CI: 125o- 147o) for TLTV. These results infer that each type of vertebra has independent measurable criteria to identify it. High correlation coefficients demonstrated the repeatability of the measurements using skeletal remains (0.94 < r < 0.97) and CT-scans (0.978< r < 0.997). CONCLUSION: The results strongly infer that quantitative morphometry from the superior articular facets of vertebrae can differentiate between T12, L1 and TLTV using radio-images or skeletal remains. This study also concludes that individuals with one defect or congenital malformation in the spine are more likely to have at least one other associated anomaly of the spine. Anatomy PhD (Anatomy) Unrestricted 2022-02-14T11:20:05Z 2022-02-14T11:20:05Z 2022-04 2021-12 Dissertation * A2022 http://hdl.handle.net/2263/83869 DOI: 10.25403/UPresearchdata.19169333 © 2022 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | UCTD Quantitative differentiation Quantitative differentiation of thoracolumbar transitional vertebrae : possible embryological origins and associations with other anomalies in the vertebral column |
| title | Quantitative differentiation of thoracolumbar transitional vertebrae : possible embryological origins and associations with other anomalies in the vertebral column |
| title_full | Quantitative differentiation of thoracolumbar transitional vertebrae : possible embryological origins and associations with other anomalies in the vertebral column |
| title_fullStr | Quantitative differentiation of thoracolumbar transitional vertebrae : possible embryological origins and associations with other anomalies in the vertebral column |
| title_full_unstemmed | Quantitative differentiation of thoracolumbar transitional vertebrae : possible embryological origins and associations with other anomalies in the vertebral column |
| title_short | Quantitative differentiation of thoracolumbar transitional vertebrae : possible embryological origins and associations with other anomalies in the vertebral column |
| title_sort | quantitative differentiation of thoracolumbar transitional vertebrae possible embryological origins and associations with other anomalies in the vertebral column |
| topic | UCTD Quantitative differentiation |
| url | http://hdl.handle.net/2263/83869 |