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Evaluation of extracts of South African plant species for the treatment of venous thromboembolism
Dissertation (MSc (Medicinal Plant Science))--University of Pretoria, 2021.
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| Format: | Thesis |
| Language: | English |
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University of Pretoria
2022
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| _version_ | 1867613609227452416 |
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| access_status_str | Open Access |
| author2 | Lall, Namrita |
| author_browse | Lall, Namrita |
| author_facet | Lall, Namrita |
| collection | Thesis |
| dc_rights_str_mv | © 2022 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Dissertation (MSc (Medicinal Plant Science))--University of Pretoria, 2021. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/83897 |
| institution | University of Pretoria (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:38:52.072Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/83897 Evaluation of extracts of South African plant species for the treatment of venous thromboembolism Lall, Namrita lili.denga@gmail.com Denga, Lilitha Lwando Medicinal plants Anticoagulants Anti-FXa Antithrombotic UCTD Natural and agricultural sciences theses SDG-03 Natural and agricultural sciences theses SDG-09 Natural and agricultural sciences theses SDG-15 Dissertation (MSc (Medicinal Plant Science))--University of Pretoria, 2021. Venous thromboembolism (VTE) is a collective term for the cardiovascular diseases, deep vein thrombosis and pulmonary embolism. Many of those who live in developing countries rely on herbal medicinal products as a primary source of healthcare. Thrombosis causes the progression of VTE; thus, the study investigated the antithrombotic properties of selected plant extracts. Thirty-three (33) plant extracts were prepared from 11 South African medicinal plants using ethanol, dichloromethane and water. The extracts were tested for liver antiproliferative effects as well as antioxidant, anti-FXa (activated coagulation factor X) and cyclooxygenase-1 (COX-1) inhibitory activity. The phytochemistry of the plant extract with note-worthy activity, was also determined. The ethanolic extract of Hypoestes forskaolii had the most potent antiproliferative activity at a IC50 (50 percent inhibitory concentration) lower than 3.13μg/mL. The most potent antioxidant was the aqueous extract of Heteropyxis natalensis (IC50 = 2.71μg/mL), which also displayed potent anti-FXa activity with a IC50 value of 2.64μg/mL. The same extract inhibited COX-1 at a IC50 value of 25.32μg/mL. The presence of β-carotene was confirmed in the aqueous extract of H. natalensis. Amongst the 33 extracts tested, the aqueous extract of H. natalensis was the best candidate for future antithrombotic studies for VTE. NRF bs2026 Plant Science MSc (Medicinal Plant Science) Unrestricted SDG-03: Good health and well-being SDG-09: Industry, innovation and infrastructure SDG-15: Life on land 2022-02-14T13:48:08Z 2022-02-14T13:48:08Z 2022-04 2021 Dissertation * A2022 http://hdl.handle.net/2263/83897 en © 2022 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | Medicinal plants Anticoagulants Anti-FXa Antithrombotic UCTD Natural and agricultural sciences theses SDG-03 Natural and agricultural sciences theses SDG-09 Natural and agricultural sciences theses SDG-15 Evaluation of extracts of South African plant species for the treatment of venous thromboembolism |
| title | Evaluation of extracts of South African plant species for the treatment of venous thromboembolism |
| title_full | Evaluation of extracts of South African plant species for the treatment of venous thromboembolism |
| title_fullStr | Evaluation of extracts of South African plant species for the treatment of venous thromboembolism |
| title_full_unstemmed | Evaluation of extracts of South African plant species for the treatment of venous thromboembolism |
| title_short | Evaluation of extracts of South African plant species for the treatment of venous thromboembolism |
| title_sort | evaluation of extracts of south african plant species for the treatment of venous thromboembolism |
| topic | Medicinal plants Anticoagulants Anti-FXa Antithrombotic UCTD Natural and agricultural sciences theses SDG-03 Natural and agricultural sciences theses SDG-09 Natural and agricultural sciences theses SDG-15 |
| url | http://hdl.handle.net/2263/83897 |