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In silico docking and ADMET studies on clinical targets for type 2 diabetes correlated to in vitro inhibition of pancreatic alpha-amylase and alpha-glucosidase by rutin, caffeic acid, p-coumaric acid, and vanillin
Dissertation (MSc (Biochemistry))--University of Pretoria, 2021.
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| Format: | Thesis |
| Language: | English |
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University of Pretoria
2022
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| _version_ | 1867613712668426240 |
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| access_status_str | Open Access |
| author2 | Apostolides, Zeno |
| author_browse | Apostolides, Zeno |
| author_facet | Apostolides, Zeno |
| collection | Thesis |
| dc_rights_str_mv | © 2022 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Dissertation (MSc (Biochemistry))--University of Pretoria, 2021. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/83924 |
| institution | University of Pretoria (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:40:30.710Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/83924 In silico docking and ADMET studies on clinical targets for type 2 diabetes correlated to in vitro inhibition of pancreatic alpha-amylase and alpha-glucosidase by rutin, caffeic acid, p-coumaric acid, and vanillin Apostolides, Zeno u16016760@tuks.co.za Bester, Megan J. McMillan, Jamie UCTD Biochemistry Dissertation (MSc (Biochemistry))--University of Pretoria, 2021. Diabetes mellitus affects millions of people worldwide and if left untreated leads to many serious complications such as hypertension, stroke, coma, or even death. Although drugs are commercially available, often these are unaffordable and have undesirable side effects. Therefore, discovering new and more effective treatments is of importance. Several edible plants have been found to have antidiabetic properties and the compounds contributing to activity may be an alternative source of compounds for the treatment of type 2 diabetes (T2D). The study aimed to analyse the in silico properties, the digestive enzyme inhibition and cellular glucose-uptake inducing ability of the selected compounds present in herbs, spices, and medicinal plants. NRF Biochemistry MSc (Biochemistry) Unrestricted 2022-02-15T08:11:05Z 2022-02-15T08:11:05Z 2022-04 2021 Dissertation McMillan, J 2022, In silico docking and ADMET studies on clinical targets for type 2 diabetes correlated to in vitro inhibition of pancreatic alpha-amylase and alpha-glucosidase by rutin, caffeic acid, p-coumaric acid, and vanillin, MSc dissertation, University of Pretoria, Pretoria http://hdl.handle.net/2263/83924 A2022 http://hdl.handle.net/2263/83924 en © 2022 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | UCTD Biochemistry In silico docking and ADMET studies on clinical targets for type 2 diabetes correlated to in vitro inhibition of pancreatic alpha-amylase and alpha-glucosidase by rutin, caffeic acid, p-coumaric acid, and vanillin |
| title | In silico docking and ADMET studies on clinical targets for type 2 diabetes correlated to in vitro inhibition of pancreatic alpha-amylase and alpha-glucosidase by rutin, caffeic acid, p-coumaric acid, and vanillin |
| title_full | In silico docking and ADMET studies on clinical targets for type 2 diabetes correlated to in vitro inhibition of pancreatic alpha-amylase and alpha-glucosidase by rutin, caffeic acid, p-coumaric acid, and vanillin |
| title_fullStr | In silico docking and ADMET studies on clinical targets for type 2 diabetes correlated to in vitro inhibition of pancreatic alpha-amylase and alpha-glucosidase by rutin, caffeic acid, p-coumaric acid, and vanillin |
| title_full_unstemmed | In silico docking and ADMET studies on clinical targets for type 2 diabetes correlated to in vitro inhibition of pancreatic alpha-amylase and alpha-glucosidase by rutin, caffeic acid, p-coumaric acid, and vanillin |
| title_short | In silico docking and ADMET studies on clinical targets for type 2 diabetes correlated to in vitro inhibition of pancreatic alpha-amylase and alpha-glucosidase by rutin, caffeic acid, p-coumaric acid, and vanillin |
| title_sort | in silico docking and admet studies on clinical targets for type 2 diabetes correlated to in vitro inhibition of pancreatic alpha amylase and alpha glucosidase by rutin caffeic acid p coumaric acid and vanillin |
| topic | UCTD Biochemistry |
| url | http://hdl.handle.net/2263/83924 |