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The effect of the ex vivo addition of vitamin D on the prothrombotic and fibrinolytic potential in prostate cancer patients' blood.
Dissertation (MSc (Human Physiology))--University of Pretoria, 2022.
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| Format: | Thesis |
| Language: | English |
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University of Pretoria
2022
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| _version_ | 1867613547995856896 |
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| access_status_str | Open Access |
| author2 | Bester, Janette |
| author_browse | Bester, Janette |
| author_facet | Bester, Janette |
| collection | Thesis |
| dc_rights_str_mv | © 2022 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Dissertation (MSc (Human Physiology))--University of Pretoria, 2022. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/85065 |
| institution | University of Pretoria (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:37:53.400Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/85065 The effect of the ex vivo addition of vitamin D on the prothrombotic and fibrinolytic potential in prostate cancer patients' blood. Bester, Janette u14005914@tuks.co.za Allummoottil, Sajee Schultz, Michelle UCTD Prostate Cancer vitamin D hypercoagulable morphology viscoelasticity Dissertation (MSc (Human Physiology))--University of Pretoria, 2022. Cancer and its consequences are amongst the major causes of death worldwide. Prostate cancer (PCa) is the most frequent non-cutaneous malignancy in men globally, with South Africa having the fourth highest prostate cancer mortality rate in the world. Patients diagnosed with PCa have been found to have a hypercoagulable state as a result of the elevated systemic inflammation that is a hallmark of cancer. Vitamin D supplementation has been shown in recent studies to improve the survival rates of individuals with PCa due to its anti-tumorigenesis properties. Given the link between chronic inflammation, hypercoagulation and PCa survival rates, improving the thrombotic status of PCa patients could be beneficial in the management of these patients. This study investigated the hypercoagulable state of both metastatic and nonmetastatic PCa patients, in comparison to a reference group, before and after the ex vivo supplementation with vitamin D. The morphological and viscoelastic properties of whole blood and platelet poor plasma were investigated using light microscopy, scanning electron microscopy and thromboelastography®. This study indicated that vitamin D supplementation might potentially aid the pathology caused by abnormal RBC shape, albeit caution should be used in metastatic PCa populations since supplementation was seen to result in a tendency to create stronger, more rigid clots at a faster pace. Although vitamin D supplementation shows potential as a more cost-effective therapy regime for the elevated thrombotic risk commonly seen in individuals with PCa, additional research is needed to determine the impact of vitamin D supplementation on hypercoagulability in vivo. National Research Foundation (NRF) Physiology MSc (Human Physiology) Unrestricted 2022-05-04T12:47:58Z 2022-05-04T12:47:58Z 2022-09 2022 Dissertation * S2022 https://repository.up.ac.za/handle/2263/85065 10.25403/UPresearchdata.19732105 en © 2022 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | UCTD Prostate Cancer vitamin D hypercoagulable morphology viscoelasticity The effect of the ex vivo addition of vitamin D on the prothrombotic and fibrinolytic potential in prostate cancer patients' blood. |
| title | The effect of the ex vivo addition of vitamin D on the prothrombotic and fibrinolytic potential in prostate cancer patients' blood. |
| title_full | The effect of the ex vivo addition of vitamin D on the prothrombotic and fibrinolytic potential in prostate cancer patients' blood. |
| title_fullStr | The effect of the ex vivo addition of vitamin D on the prothrombotic and fibrinolytic potential in prostate cancer patients' blood. |
| title_full_unstemmed | The effect of the ex vivo addition of vitamin D on the prothrombotic and fibrinolytic potential in prostate cancer patients' blood. |
| title_short | The effect of the ex vivo addition of vitamin D on the prothrombotic and fibrinolytic potential in prostate cancer patients' blood. |
| title_sort | effect of the ex vivo addition of vitamin d on the prothrombotic and fibrinolytic potential in prostate cancer patients blood |
| topic | UCTD Prostate Cancer vitamin D hypercoagulable morphology viscoelasticity |
| url | https://repository.up.ac.za/handle/2263/85065 |