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A morphological study of the shape of the corpus callosum in normal, schizophrenic and bipolar patients
Dissertation (MSc (Neurophysiology))--University of Pretoria, 2022.
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| Format: | Thesis |
| Language: | English |
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University of Pretoria
2022
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| _version_ | 1867613673329000448 |
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| access_status_str | Open Access |
| author2 | Human-Baron, René |
| author_browse | Human-Baron, René |
| author_facet | Human-Baron, René |
| collection | Thesis |
| dc_rights_str_mv | © 2022 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Dissertation (MSc (Neurophysiology))--University of Pretoria, 2022. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/85157 |
| institution | University of Pretoria (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:39:53.208Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/85157 A morphological study of the shape of the corpus callosum in normal, schizophrenic and bipolar patients Human-Baron, René tiaan@neurolink.co.za du Toit, Peet J Venter, Gerda Vermeulen, Christiaan Louis UCTD Corpus callosum Bipolar Landmarks Morphology Schizophrenia Dissertation (MSc (Neurophysiology))--University of Pretoria, 2022. Abnormalities in the morphology of the corpus callosum (CC) have previously been found to be involved in the cognitive impairments or abnormal behaviour seen in patients with mental disorders such as schizophrenia and bipolar disorder. The present study investigated morphological shape differences of the CC in a large cohort of 223 participants between normal, schizophrenic, and bipolar patients on midsagittal sections of MRI scans (n=111), and CT scans (n=62) and cadaver (n=50) samples. Healthy population samples were compared to a mental disorder population sample in order to determine potential morphological shape variations associated with schizophrenia and bipolar disorder to aid in the disorder diagnostic process. Landmark-based methodology was used to contour the CC shape by plotting 29 landmarks that served as standard positions to allow for radial partitioning and thickness partitioning to be performed in order to determine shape variations within the specific localized anatomical sections of the CC. Shape analysis was performed using Ordinary Procrustes averaging and superimposing the landmarks of samples to define an average landmark position for the specific regions of the CC. The results showed no significant global or region-specific sex or age-related CC shape differences across the entire study sample as well as within sample groups. No significant shape differences were found between the different mental disorders. Although not significant, schizophrenia and bipolar CC shapes differed mostly in the genu-rostrum, posterior body, isthmus, and splenium. Sample group comparisons yielded significant differences between all sample groups for all global CC measurement parameters and in various CC sub-regions. The findings of the present study, suggest that the CC in schizophrenia and bipolar differs significantly compared to healthy controls, specifically in the anterior body and isthmus for schizophrenia and only in the isthmus for bipolar disorder. Physiology MSc (Neurophysiology) Unrestricted 2022-05-09T13:18:12Z 2022-05-09T13:18:12Z 2022 2022 Dissertation * S2022 https://repository.up.ac.za/handle/2263/85157 en © 2022 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | UCTD Corpus callosum Bipolar Landmarks Morphology Schizophrenia A morphological study of the shape of the corpus callosum in normal, schizophrenic and bipolar patients |
| title | A morphological study of the shape of the corpus callosum in normal, schizophrenic and bipolar patients |
| title_full | A morphological study of the shape of the corpus callosum in normal, schizophrenic and bipolar patients |
| title_fullStr | A morphological study of the shape of the corpus callosum in normal, schizophrenic and bipolar patients |
| title_full_unstemmed | A morphological study of the shape of the corpus callosum in normal, schizophrenic and bipolar patients |
| title_short | A morphological study of the shape of the corpus callosum in normal, schizophrenic and bipolar patients |
| title_sort | morphological study of the shape of the corpus callosum in normal schizophrenic and bipolar patients |
| topic | UCTD Corpus callosum Bipolar Landmarks Morphology Schizophrenia |
| url | https://repository.up.ac.za/handle/2263/85157 |