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An epidemiological study of canine lymphoma in South Africa
Dissertation (MSc (Veterinary Science))--University of Pretoria, 2022.
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| Format: | Thesis |
| Language: | English |
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University of Pretoria
2023
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| _version_ | 1867613696095682560 |
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| access_status_str | Open Access |
| author2 | Rautenbach, Yolandi |
| author_browse | Rautenbach, Yolandi |
| author_facet | Rautenbach, Yolandi |
| collection | Thesis |
| dc_rights_str_mv | © 2021 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Dissertation (MSc (Veterinary Science))--University of Pretoria, 2022. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/92179 |
| institution | University of Pretoria (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:40:14.906Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/92179 An epidemiological study of canine lymphoma in South Africa Rautenbach, Yolandi sybrandharris@gmail.com Hooijberg, Emma Henriette Harris, Sybrand Ben UCTD Canine lymphoma (cL) Epidemiological information Retrospective case-controlled study Dissertation (MSc (Veterinary Science))--University of Pretoria, 2022. Breed, age, and sex predispositions for canine lymphoma (cL) have been reported for various locations. However, epidemiological information concerning cL in South Africa is scarce. The objective of the study was to describe the epidemiologic and histological features of cL and the frequency of World Health Organisation (WHO) classification subtypes in South Africa. A retrospective case-controlled study was performed that included 342 cases, submitted between December 2018 – December 2020, with a histopathological diagnosis of cL, matched with non-cL control cases. Associations between cL and breed, sex and age were assessed using univariate and multivariable conditional logistic regression. Associations were reported as odds ratios (ORs) and significance set as P ≤ 0.05. Breed, in general, was significantly associated with cL, but age, sex, and neutering status were not. Median population age was 8 years, with a male to female ratio of 1.2:1. The Boerboel had an increased (OR = 3.25, P = 0.004) and the Yorkshire Terrier a decreased risk (OR = 0.17, P = 0.004) of developing cL. The Boerboel cL group (n = 27) had a younger median age of 6 years and a higher male to female ratio of 1.5:1. Immunophenotyping was performed on 119 (35%) cases, of which 82 (69%) were B-cell, 34 (29%) T-cell and 3 (2%) neither. World Health Organisation classification subtypes were available for 88 cases; of these 66 (75%) were diffuse large B-cell lymphoma (DLBCL) with remaining subtypes each ≤7%. All Boerboel cases (n =4) that were WHO subtyped were DLBCL. This study confirmed a breed predisposition for cL in the Boerboel, a South African mastiff-type dog, as previously reported. However, the lack of association between age, sex, and other breeds, and cL, was unexpected. The frequency of immunophenotypes and WHO classification subtypes were largely similar to findings in other locations. The study results suggest a possible predilection for B-cell lymphoma in the Boerboel. Companion Animal Clinical Studies MSc (Veterinary Science) Unrestricted 2023-09-04T12:58:38Z 2023-09-04T12:58:38Z 2023-04 2022 Dissertation * A2023 http://hdl.handle.net/2263/92179 en © 2021 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | UCTD Canine lymphoma (cL) Epidemiological information Retrospective case-controlled study An epidemiological study of canine lymphoma in South Africa |
| title | An epidemiological study of canine lymphoma in South Africa |
| title_full | An epidemiological study of canine lymphoma in South Africa |
| title_fullStr | An epidemiological study of canine lymphoma in South Africa |
| title_full_unstemmed | An epidemiological study of canine lymphoma in South Africa |
| title_short | An epidemiological study of canine lymphoma in South Africa |
| title_sort | epidemiological study of canine lymphoma in south africa |
| topic | UCTD Canine lymphoma (cL) Epidemiological information Retrospective case-controlled study |
| url | http://hdl.handle.net/2263/92179 |