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Development of a screening algorithm for the cervical cancer prevention programme in Botswana
Thesis (PhD (Obstetrics and Gynaecology))--Univerisity of Pretoria, 2023.
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| Format: | Thesis |
| Language: | English |
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University of Pretoria
2023
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| _version_ | 1867613517458178048 |
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| access_status_str | Open Access |
| author2 | Dreyer, Greta |
| author_browse | Dreyer, Greta |
| author_facet | Dreyer, Greta |
| collection | Thesis |
| dc_rights_str_mv | © 2023 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Thesis (PhD (Obstetrics and Gynaecology))--Univerisity of Pretoria, 2023. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/93187 |
| institution | University of Pretoria (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:37:24.530Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/93187 Development of a screening algorithm for the cervical cancer prevention programme in Botswana Dreyer, Greta doreen.masire@gmail.com Hofmeyr, Justus Morroni, Chelsea Ramogola-Masire, Doreen UCTD Histological verification Cervical cancer screening Colposcopy Test performance Human immunodeficiency virus (HIV) Botswana Health sciences theses SDG-03 SDG-03: Good health and well-being Thesis (PhD (Obstetrics and Gynaecology))--Univerisity of Pretoria, 2023. In this thesis, Development of a screening algorithm for the cervical cancer prevention programme in Botswana, the candidate utilised a new human papillomavirus (HPV) deoxyribonucleic acid (DNA) assay called Antila AmpFire to test for high-risk HPV in a semi-urban area in Botswana. This prospective cohort study evaluated several triage methods for high-risk HPV screen-positive women. The methods were visual inspection after acetic acid, colposcopy, and various partial HPV genotypes. Performance of the various triage methods were calculated and compared to that of the primary hrHPV screening. Restricted 8-hrPHV (16,18,31,33,35,45,52,58) maintained the highest sensitivity of all the triage methods. Although our finding supported the 8-hrHPV triage method as the most effective strategy, additional research is needed to guide further management as the relatively poor specificity of this method would still lead to overtreatment of women with no established precancer disease. Obstetrics and Gynaecology PhD (Obstetrics and Gynaecology) Unrestricted 2023-11-07T12:05:26Z 2023-11-07T12:05:26Z 2024-04 2023 Thesis * S2024 http://hdl.handle.net/2263/93187 DOI: https://doi.org/10.25403/UPresearchdata.24476977.v1 https://doi.org/10.25403/UPresearchdata.24476977 en © 2023 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | UCTD Histological verification Cervical cancer screening Colposcopy Test performance Human immunodeficiency virus (HIV) Botswana Health sciences theses SDG-03 SDG-03: Good health and well-being Development of a screening algorithm for the cervical cancer prevention programme in Botswana |
| title | Development of a screening algorithm for the cervical cancer prevention programme in Botswana |
| title_full | Development of a screening algorithm for the cervical cancer prevention programme in Botswana |
| title_fullStr | Development of a screening algorithm for the cervical cancer prevention programme in Botswana |
| title_full_unstemmed | Development of a screening algorithm for the cervical cancer prevention programme in Botswana |
| title_short | Development of a screening algorithm for the cervical cancer prevention programme in Botswana |
| title_sort | development of a screening algorithm for the cervical cancer prevention programme in botswana |
| topic | UCTD Histological verification Cervical cancer screening Colposcopy Test performance Human immunodeficiency virus (HIV) Botswana Health sciences theses SDG-03 SDG-03: Good health and well-being |
| url | http://hdl.handle.net/2263/93187 https://doi.org/10.25403/UPresearchdata.24476977 |