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Clinical and epidemiological investigations of Orbivirus infections in domestic dogs (Canis lupus familiaris)
Thesis (PhD (Veterinary Science))--University of Pretoria, 2023.
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| Format: | Thesis |
| Language: | English |
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University of Pretoria
2024
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| _version_ | 1867613487045279744 |
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| access_status_str | Open Access |
| author2 | Fosgate, Geoffrey Theodore |
| author_browse | Fosgate, Geoffrey Theodore |
| author_facet | Fosgate, Geoffrey Theodore |
| collection | Thesis |
| dc_rights_str_mv | © 2023 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Thesis (PhD (Veterinary Science))--University of Pretoria, 2023. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/94952 |
| institution | University of Pretoria (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:36:55.449Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/94952 Clinical and epidemiological investigations of Orbivirus infections in domestic dogs (Canis lupus familiaris) Fosgate, Geoffrey Theodore joe.hanekom@up.ac.za Guthrie, Alan John Leisewitz, Andrew L. Hanekom, Josef Derek UCTD African horse sickness Bluetongue virus Equine encephalosis virus Seroprevalence Risk factors Clinical presentation and treatment WOAH-listed diseases Importation risk Thesis (PhD (Veterinary Science))--University of Pretoria, 2023. Dogs are atypical host species for some of the most economically important orbiviral diseases, African horse sickness (AHS) and bluetongue (BT). Dogs are the only non-equid species to develop the severe fatal form of AHS, and along with the Eurasian lynx, dogs are the only non-ruminants to develop fatal bluetongue (BT). However, the role of dogs as a host species for orbiviruses has been largely dismissed as incidental or of low significance in the epidemiology of orbiviruses. In light of recent dog mortalities due to AHS which occurred with suspected midge-borne transmission, this thesis examines clinical and epidemiological features of Orbivirus diseases in South African dogs. The author shows that exposure to the African horse sickness virus (AHSV) in dogs in Tshwane, South Africa was common and frequent, with as many dogs estimated to have been exposed to AHSV as the population of horses in the area. At the onset of this investigation, only AHS had been described in South African dogs. The author describes the novel identification of the bluetongue virus (BTV) and possible equine encephalosis virus in South African dogs. The author describes the clinical presentation and management of a pregnant dog diagnosed with naturally occurring BT. The author investigates the farm of origin for this dog and shows a high level of exposure to BTV in dogs on the farm was high and detected the viral RNA from blood samples in three dogs (50%). The author reports the detection of equine encephalosis from samples collected from a puppy with a fatal respiratory disease. The findings of this study suggest dogs could play a greater role in the persistence, spread and introduction of orbiviruses than previously thought. Companion Animal Clinical Studies PhD (Veterinary Science) Unrestricted Faculty of Veterinary Science SDG-02: Zero Hunger SDG-03: Good health and well-being SDG-15: Life on land 2024-02-27T10:04:11Z 2024-02-27T10:04:11Z 2024-05-03 2023-11-12 Dissertation * A2024 http://hdl.handle.net/2263/94952 https://doi.org/10.25403/UPresearchdata.25133759 en © 2023 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | UCTD African horse sickness Bluetongue virus Equine encephalosis virus Seroprevalence Risk factors Clinical presentation and treatment WOAH-listed diseases Importation risk Clinical and epidemiological investigations of Orbivirus infections in domestic dogs (Canis lupus familiaris) |
| title | Clinical and epidemiological investigations of Orbivirus infections in domestic dogs (Canis lupus familiaris) |
| title_full | Clinical and epidemiological investigations of Orbivirus infections in domestic dogs (Canis lupus familiaris) |
| title_fullStr | Clinical and epidemiological investigations of Orbivirus infections in domestic dogs (Canis lupus familiaris) |
| title_full_unstemmed | Clinical and epidemiological investigations of Orbivirus infections in domestic dogs (Canis lupus familiaris) |
| title_short | Clinical and epidemiological investigations of Orbivirus infections in domestic dogs (Canis lupus familiaris) |
| title_sort | clinical and epidemiological investigations of orbivirus infections in domestic dogs canis lupus familiaris |
| topic | UCTD African horse sickness Bluetongue virus Equine encephalosis virus Seroprevalence Risk factors Clinical presentation and treatment WOAH-listed diseases Importation risk |
| url | http://hdl.handle.net/2263/94952 https://doi.org/10.25403/UPresearchdata.25133759 |