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Circulating markers of endothelial activation in canine parvoviral 4 enteritis
Dissertation (MSc (Small Animal Medicine))--University of Pretoria, 2021.
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| Format: | Thesis |
| Language: | English |
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University of Pretoria
2024
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| _version_ | 1867613483475927040 |
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| access_status_str | Open Access |
| author2 | Pazzi, Paolo |
| author_browse | Pazzi, Paolo |
| author_facet | Pazzi, Paolo |
| collection | Thesis |
| dc_rights_str_mv | © 2021 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Dissertation (MSc (Small Animal Medicine))--University of Pretoria, 2021. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/95627 |
| institution | University of Pretoria (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:36:52.135Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/95627 Circulating markers of endothelial activation in canine parvoviral 4 enteritis Pazzi, Paolo sunepretorius@rocketmail.com Pretorius, Suné UCTD Canine parvovirus VCAM-1 Leukocytes ICAM-1 HMGB-1 Dissertation (MSc (Small Animal Medicine))--University of Pretoria, 2021. Canine parvovirus (CPV) is a debilitating disease affecting young wild and domestic canines. Canine parvovirus attacks rapidly dividing cells including intestinal epithelium, lymphoid tissue and bone marrow. The most common clinical manifestations of CPV infection are severe gastrointestinal signs and immunosuppression. During CPV, endotoxins are released from the compromised gastrointestinal tract. Increased inflammatory cytokines have been described in previous studies. The endotoxins, raised inflammatory cytokines and the severe immunosuppression stimulates the systemic inflammatory response causing widespread peripheral vasodilation, capillary permeability is increased, cardiac function depression and the coagulation cascade is activated. The state of the endothelium in CPV has not been investigated. Markers of endothelial activation including intercellular adhesive molecule-1 (ICAM-1), vascular adhesive molecule-1 (VCAM-1) and high mobility group box-1 protein (HMGB-1) give insight into the state of vascular endothelium during disease. These markers of endothelial activation have been investigated in inflammatory diseases in humans and animals. In this study, we aimed to investigate the concentration of circulating markers of endothelial activation to gain insight into the state of vascular endothelium during CPV. Thirty dogs naturally infected with CPV were used in the study and compared to ten age-matched control dogs. A significant lower median value for ICAM-1 was found in dogs with CPV compared to control dogs. No significant difference was seen for VCAM-1 or HMGB-1. This indicates that despite the systemic inflammation and raised cytokine levels seen in dogs with CPV there seems to be a lack of endothelial activation based on the circulating levels of the markers of endothelial activation. The significance of these findings warrants further investigation. Companion Animal Clinical Studies MSc (Small Animal Medicine) Unrestricted 2024-04-17T14:15:48Z 2024-04-17T14:15:48Z 2021 2021-04 Dissertation * S2021 http://hdl.handle.net/2263/95627 en © 2021 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | UCTD Canine parvovirus VCAM-1 Leukocytes ICAM-1 HMGB-1 Circulating markers of endothelial activation in canine parvoviral 4 enteritis |
| title | Circulating markers of endothelial activation in canine parvoviral 4 enteritis |
| title_full | Circulating markers of endothelial activation in canine parvoviral 4 enteritis |
| title_fullStr | Circulating markers of endothelial activation in canine parvoviral 4 enteritis |
| title_full_unstemmed | Circulating markers of endothelial activation in canine parvoviral 4 enteritis |
| title_short | Circulating markers of endothelial activation in canine parvoviral 4 enteritis |
| title_sort | circulating markers of endothelial activation in canine parvoviral 4 enteritis |
| topic | UCTD Canine parvovirus VCAM-1 Leukocytes ICAM-1 HMGB-1 |
| url | http://hdl.handle.net/2263/95627 |