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Titanium (IV) complexes of thianthrene and dibenzodioxin as possible antitumour agents
Dissertation (MSc (Chemistry))--University of Pretoria, 1998
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| Format: | Thesis |
| Language: | English |
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University of Pretoria
2024
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| _version_ | 1867613516542771200 |
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| access_status_str | Open Access |
| author2 | Lotz, Simon |
| author_browse | Lotz, Simon |
| author_facet | Lotz, Simon |
| collection | Thesis |
| dc_rights_str_mv | © 2024 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Dissertation (MSc (Chemistry))--University of Pretoria, 1998 |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/99524 |
| institution | University of Pretoria (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:37:23.532Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/99524 Titanium (IV) complexes of thianthrene and dibenzodioxin as possible antitumour agents Lotz, Simon Brink, Susanna Titanium Thianthrene Dibenzodioxin Antitumour agents UCTD Dissertation (MSc (Chemistry))--University of Pretoria, 1998 This study involves the synthesis and characterization of new organometallic complexes of Ti(IV). Such complexes are designed to act as possible antitumour agents and thus include ligands with specific functions. As target for biological activity, the DNA double helix was identified. These complexes include (i) a labile halogen ligand which is capable of forming a covalent bond with DNA, (ii) a planar condensed 3-membered ring system which may act as intercalator in the major groove of DNA and (iii) two bulky, non-labile stopper ligands which will control the degree of intercalation. The complexes represent two groups, namely those where the transition metal is bonded directly to the planar ring system and those where a sulphur atom is located between the metal and the ring system. The sulphur acts as a spacer and causes the ring system to be out of the plane of the metal fragment. New complexes [TiCpi(R)Cl], [TiCpi(R)2], [TiCpi(SR)Cl] and [TiCpi{SR)2 ] (R = thianthrene, dibenzodioxin) were prepared by adding the lithiated rings or the metallated thiolates to titanocene dichloride. Also studied was the insertion of titanocene dichloride into ring-opened, dilithiated thianthrene. The composition of the new complexes were determined by using NMR studies, mass spectrometry and micro analysis. The structure of [TiCpi(Db )Cl] was confirmed by a single crystal X-ray diffraction study. Since the molecular geometries of the complexes are of utmost importance for their interaction with DNA, their three-dimensional structures were also studied using computer generated spacefill models. From these results, the structures of the complexes were obtained and together with their physical features, the complexes [TiCpi(Db )Cl] and [TiCpi(DbS)Cl] were selected as the best candidates for in vivo and in vitro tests. The latter did not form part of this study. Chemistry MSc (Chemistry) 2024-11-27T09:16:06Z 2024-11-27T09:16:06Z 22/01/12 1998 Dissertation http://hdl.handle.net/2263/99524 en © 2024 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | Titanium Thianthrene Dibenzodioxin Antitumour agents UCTD Titanium (IV) complexes of thianthrene and dibenzodioxin as possible antitumour agents |
| title | Titanium (IV) complexes of thianthrene and dibenzodioxin as possible antitumour agents |
| title_full | Titanium (IV) complexes of thianthrene and dibenzodioxin as possible antitumour agents |
| title_fullStr | Titanium (IV) complexes of thianthrene and dibenzodioxin as possible antitumour agents |
| title_full_unstemmed | Titanium (IV) complexes of thianthrene and dibenzodioxin as possible antitumour agents |
| title_short | Titanium (IV) complexes of thianthrene and dibenzodioxin as possible antitumour agents |
| title_sort | titanium iv complexes of thianthrene and dibenzodioxin as possible antitumour agents |
| topic | Titanium Thianthrene Dibenzodioxin Antitumour agents UCTD |
| url | http://hdl.handle.net/2263/99524 |