Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
Synthetic and structural studies of phosphonic amides and esters
Thesis (DPhil)--University of Pretoria, 1992.
Saved in:
| Other Authors: | |
|---|---|
| Format: | Thesis |
| Language: | English |
| Published: |
University of Pretoria
2024
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613486207467520 |
|---|---|
| access_status_str | Open Access |
| author2 | Modro, T.A. |
| author_browse | Modro, T.A. |
| author_facet | Modro, T.A. |
| collection | Thesis |
| dc_rights_str_mv | © 2024 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. |
| description | Thesis (DPhil)--University of Pretoria, 1992. |
| format | Thesis |
| id | oai:repository.up.ac.za:2263/99546 |
| institution | University of Pretoria (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:36:54.588Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UPSpace — University of Pretoria Institutional Repository |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | University of Pretoria |
| publisherStr | University of Pretoria |
| record_format | dspace |
| source_str | UPSpace — University of Pretoria Institutional Repository |
| spelling | oai:repository.up.ac.za:2263/99546 Synthetic and structural studies of phosphonic amides and esters Modro, T.A. De Jongh, Connie Petrus Synthetic Structural Phosphonic Amides Esters UCTD Thesis (DPhil)--University of Pretoria, 1992. The research contained herein is of twofold nature. Firstly, we aimed to obtain a mechanistic understanding of the thermal fragmentation reaction of B-acyloxyphosphonates, and in the process we secondly aimed to develop synthetic methodology for phosphonic diamides. We showed that the fragmentation of B-acyloxyphosphonates proceeds with metaphosphate extrusion preceded by a novel type of molecular rearrangement. It is, to our knowledge, the first example in which alkyl migration from the oxygen of the phosphorus ester function to another centre (in this case carbonyl oxygen of the substrate) has to take place in order to allow metaphosphate extrusion. We succeeded m developing synthetic methodology by which alkylphosphonic and B-hydroxyalkylphosphonic diamides can be obtained in good yields using simple procedures. Reaction of the anion of HP(O)(NEt2) 2 with either alkyl halides or epoxides was used to obtain these compounds. In making alkyl- and 8-hydroxyalkylphosphonic diamides more easily accessible than before, more of the chemistry of these compounds can be studied. Chemistry DPhil 2024-11-27T09:16:11Z 2024-11-27T09:16:11Z 22/01/27 1992 Thesis http://hdl.handle.net/2263/99546 en © 2024 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. application/pdf University of Pretoria |
| spellingShingle | Synthetic Structural Phosphonic Amides Esters UCTD Synthetic and structural studies of phosphonic amides and esters |
| title | Synthetic and structural studies of phosphonic amides and esters |
| title_full | Synthetic and structural studies of phosphonic amides and esters |
| title_fullStr | Synthetic and structural studies of phosphonic amides and esters |
| title_full_unstemmed | Synthetic and structural studies of phosphonic amides and esters |
| title_short | Synthetic and structural studies of phosphonic amides and esters |
| title_sort | synthetic and structural studies of phosphonic amides and esters |
| topic | Synthetic Structural Phosphonic Amides Esters UCTD |
| url | http://hdl.handle.net/2263/99546 |