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Childhood necrotizing pneumonia in a region with high burden of tuberculosis and HIV
Thesis (MMed)--Stellenbosch University, 2017.
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| Format: | Thesis |
| Language: | en_ZA |
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Stellenbosch : Stellenbosch University
2017
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| _version_ | 1867614125524254720 |
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| access_status_str | Open Access |
| author | Jacobs, Carmen |
| author2 | Goussard, Pierre |
| author_browse | Goussard, Pierre Jacobs, Carmen |
| author_facet | Goussard, Pierre Jacobs, Carmen |
| author_sort | Jacobs, Carmen |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description | Thesis (MMed)--Stellenbosch University, 2017. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/101351 |
| institution | Stellenbosch University (South Africa) |
| language | en_ZA |
| last_indexed | 2026-06-10T12:47:03.084Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/101351 Childhood necrotizing pneumonia in a region with high burden of tuberculosis and HIV Jacobs, Carmen Goussard, Pierre Gie, Robert Peter Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Paediatrics and Child Health. Necrotizing pneumonia Tuberculosis Pleural effusions Empyema Community-acquired pneumonia HIV (Viruses) UCTD Thesis (MMed)--Stellenbosch University, 2017. ENGLISH ABSTRACT: The causes and outcome of children treated for necrotizing pneumonia (NP) in low- and middle-income countries have not been reported. The aim of this retrospective descriptive study was to investigate childhood NP in a region with a high prevalence of tuberculosis (TB) and HIV. Material and methods: Children with radiological features of childhood NP treated in a referral hospital in Western Cape, South Africa between 2004 -2007 were included. Results: Children (n=32), median age 16.5 (IQR 10-33 months) of whom 9 (32%) were HIV-infected were studied. Of the HIV-infected children, with a median blood CD4 count of 310 cells/ml, 67% were on antiretroviral treatment. On chest CT scan alveolar disease (100%), lung necrosis with cysts (88%) and pleural effusion (91%) were the commonest features; no features suggestive of pulmonary TB were observed. A causative organism was isolated in 66%. The commonest causes being: Streptococcus species (27%), Staphylococcus aureus (34%) and Mycobacterium tuberculosis (M.tb) (25%). In the TB group M.tb was cultured in 75% and the pleural fluid AFB positive in 25%. Where NP was caused by M.tb 75% were HIV-infected (p=0.007). In 47% (n=15) a surgical intervention was required: (25%) was an isolated pleural drainage. No patients died and at follow-up 6 months after admission (n=17) 82% had complete radiological resolution including the M.tb group. Conclusion: These findings indicate that in TB and HIV-prevalent countries in children with NP, TB must be actively excluded especially in HIV-infected children. "Geen opsomming beskikbaar" Masters 2017-02-13T12:57:26Z 2017-03-29T20:49:48Z 2017-02-13T12:57:26Z 2017-03-29T20:49:48Z 2017-03 Thesis http://hdl.handle.net/10019.1/101351 en_ZA Stellenbosch University 14 pages application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | Necrotizing pneumonia Tuberculosis Pleural effusions Empyema Community-acquired pneumonia HIV (Viruses) UCTD Jacobs, Carmen Childhood necrotizing pneumonia in a region with high burden of tuberculosis and HIV |
| title | Childhood necrotizing pneumonia in a region with high burden of tuberculosis and HIV |
| title_full | Childhood necrotizing pneumonia in a region with high burden of tuberculosis and HIV |
| title_fullStr | Childhood necrotizing pneumonia in a region with high burden of tuberculosis and HIV |
| title_full_unstemmed | Childhood necrotizing pneumonia in a region with high burden of tuberculosis and HIV |
| title_short | Childhood necrotizing pneumonia in a region with high burden of tuberculosis and HIV |
| title_sort | childhood necrotizing pneumonia in a region with high burden of tuberculosis and hiv |
| topic | Necrotizing pneumonia Tuberculosis Pleural effusions Empyema Community-acquired pneumonia HIV (Viruses) UCTD |
| url | http://hdl.handle.net/10019.1/101351 |
| work_keys_str_mv | AT jacobscarmen childhoodnecrotizingpneumoniainaregionwithhighburdenoftuberculosisandhiv |