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A descriptive study to determine the prevalence of TPMT polymorphism in Healthy male subjects in Central South Africa
Thesis (MMed)--Stellenbosch University, 2014.
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| Other Authors: | |
| Format: | Thesis |
| Language: | en_ZA |
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Stellenbosch : Stellenbosch University
2017
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| _version_ | 1867613948676669440 |
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| access_status_str | Open Access |
| author | Ferreira, Maria Magdalena |
| author2 | Rosenkranz, B. |
| author_browse | Ferreira, Maria Magdalena Rosenkranz, B. |
| author_facet | Rosenkranz, B. Ferreira, Maria Magdalena |
| author_sort | Ferreira, Maria Magdalena |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description | Thesis (MMed)--Stellenbosch University, 2014. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/102008 |
| institution | Stellenbosch University (South Africa) |
| language | en_ZA |
| last_indexed | 2026-06-10T12:44:15.221Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/102008 A descriptive study to determine the prevalence of TPMT polymorphism in Healthy male subjects in Central South Africa Ferreira, Maria Magdalena Rosenkranz, B. Stellenbosch University. Facutly of Medicine and Health Sciences. Department of Medicine. Division of Clinical Pharmacology. Chromosome polymorphism -- Male patients -- South Africa Chromosome polymorphism -- Incidence -- South Africa UCTD Thesis (MMed)--Stellenbosch University, 2014. ENGLISH SUMMARY : Thiopurine medications e.g. Azathioprine and 6-Mercaptopurine are metabolized by the thiopurine methyltransferase (TPMT) enzyme. This enzyme activity is highly variable due to polymorphism of the TPMT gene. TPMT genotyping can be performed to tailor the treatment with thiopurine medications specifically to the patient's TPMT activity. AFRIKAANSE OPSOMMING : Geen opsomming beskikbaar. Research Report 2017-07-26T12:39:20Z 2020-07-21T03:00:12Z 2014-03 Thesis http://hdl.handle.net/10019.1/102008 en_ZA Stellenbosch University 24 pages application/pdf application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | Chromosome polymorphism -- Male patients -- South Africa Chromosome polymorphism -- Incidence -- South Africa UCTD Ferreira, Maria Magdalena A descriptive study to determine the prevalence of TPMT polymorphism in Healthy male subjects in Central South Africa |
| title | A descriptive study to determine the prevalence of TPMT polymorphism in Healthy male subjects in Central South Africa |
| title_full | A descriptive study to determine the prevalence of TPMT polymorphism in Healthy male subjects in Central South Africa |
| title_fullStr | A descriptive study to determine the prevalence of TPMT polymorphism in Healthy male subjects in Central South Africa |
| title_full_unstemmed | A descriptive study to determine the prevalence of TPMT polymorphism in Healthy male subjects in Central South Africa |
| title_short | A descriptive study to determine the prevalence of TPMT polymorphism in Healthy male subjects in Central South Africa |
| title_sort | descriptive study to determine the prevalence of tpmt polymorphism in healthy male subjects in central south africa |
| topic | Chromosome polymorphism -- Male patients -- South Africa Chromosome polymorphism -- Incidence -- South Africa UCTD |
| url | http://hdl.handle.net/10019.1/102008 |
| work_keys_str_mv | AT ferreiramariamagdalena adescriptivestudytodeterminetheprevalenceoftpmtpolymorphisminhealthymalesubjectsincentralsouthafrica AT ferreiramariamagdalena descriptivestudytodeterminetheprevalenceoftpmtpolymorphisminhealthymalesubjectsincentralsouthafrica |