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Comparing the diagnosis of gestational diabetes using the oral glucose tolerance test and a designed breakfast in a randomised, cross-over trial
Thesis (PhD)--Stellenbosch University, 2022.
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| Format: | Thesis |
| Language: | en_ZA |
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Stellenbosch : Stellenbosch University
2017
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| _version_ | 1867614021633441792 |
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| access_status_str | Open Access |
| author | Marais, Colin |
| author2 | Hall, David Raymond |
| author_browse | Hall, David Raymond Marais, Colin |
| author_facet | Hall, David Raymond Marais, Colin |
| author_sort | Marais, Colin |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description | Thesis (PhD)--Stellenbosch University, 2022. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/102552 |
| institution | Stellenbosch University (South Africa) |
| language | en_ZA |
| last_indexed | 2026-06-10T12:45:24.995Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/102552 Comparing the diagnosis of gestational diabetes using the oral glucose tolerance test and a designed breakfast in a randomised, cross-over trial Marais, Colin Hall, David Raymond Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Paediatrics and Child Health. Diabetes in pregnancy Glucose tolerance tests Antenatal clinic UCTD Thesis (PhD)--Stellenbosch University, 2022. ENGLISH ABSTRACT: Objective This study compared a standardised, user-friendly designed breakfast (DB) to the 75g OGTT, comparing venous and capillary glucose values for the diagnosis of gestational diabetes. Methods 6 prospective, randomised, cross-over trial comparing the gold standard OGTT to a designed breakfast glucose profile (DBGP) in the diagnosis of gestational diabetes, was performed from March to December 2015. Fifty-one patients, attending the high-risk antenatal clinic at Tygerberg Hospital, were randomised to OGTT or DBGP at baseline. One week later, before intervention, the alternative test was performed. Fasting and 2-hour, venous and capillary values were measured. Patients qualified for screening on risk factors: previous gestational diabetes, previous unexplained intra-uterine death, previous macrosomic baby, booking BMI >40 kg/m2, age >40 years, affected first degree relative, susceptible family origin (Asiatic), acanthosis nigricans and polycystic ovarian syndrome. Results Fasting and 2-hour capillary glucose values measured during the OGTT correlated significantly with laboratory venous samples (Pearson's 0.74; p <0.001 at both time intervals). The 2-hour capillary glucose values obtained for the DB showed satisfactory correlation to the current gold standard OGTT (Pearson's 0.54; p <0.001). Conclusions The designed breakfast glucose profile provides a user-friendly, sufficiently accurate, promising alternative to diagnose GDM that deserves further investigation. "Geen opsomming beskikbaar" Doctorate 2017-11-23T10:59:55Z 2017-12-11T10:24:18Z 2017-11-23T10:59:55Z 2017-12-11T10:24:18Z 2017-12 Thesis http://hdl.handle.net/10019.1/102552 en_ZA Stellenbosch University 19 pages application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | Diabetes in pregnancy Glucose tolerance tests Antenatal clinic UCTD Marais, Colin Comparing the diagnosis of gestational diabetes using the oral glucose tolerance test and a designed breakfast in a randomised, cross-over trial |
| title | Comparing the diagnosis of gestational diabetes using the oral glucose tolerance test and a designed breakfast in a randomised, cross-over trial |
| title_full | Comparing the diagnosis of gestational diabetes using the oral glucose tolerance test and a designed breakfast in a randomised, cross-over trial |
| title_fullStr | Comparing the diagnosis of gestational diabetes using the oral glucose tolerance test and a designed breakfast in a randomised, cross-over trial |
| title_full_unstemmed | Comparing the diagnosis of gestational diabetes using the oral glucose tolerance test and a designed breakfast in a randomised, cross-over trial |
| title_short | Comparing the diagnosis of gestational diabetes using the oral glucose tolerance test and a designed breakfast in a randomised, cross-over trial |
| title_sort | comparing the diagnosis of gestational diabetes using the oral glucose tolerance test and a designed breakfast in a randomised cross over trial |
| topic | Diabetes in pregnancy Glucose tolerance tests Antenatal clinic UCTD |
| url | http://hdl.handle.net/10019.1/102552 |
| work_keys_str_mv | AT maraiscolin comparingthediagnosisofgestationaldiabetesusingtheoralglucosetolerancetestandadesignedbreakfastinarandomisedcrossovertrial |