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Flux balance analysis of Plasmodium falciparum growth and energy metabolism
Thesis (MSc)--Stellenbosch University, 2017.
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| Other Authors: | |
| Format: | Thesis |
| Language: | en_ZA |
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Stellenbosch : Stellenbosch University
2017
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| _version_ | 1867613994479517697 |
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| access_status_str | Open Access |
| author | Burger, Robert William |
| author2 | Snoep, Jacky L. |
| author_browse | Burger, Robert William Snoep, Jacky L. |
| author_facet | Snoep, Jacky L. Burger, Robert William |
| author_sort | Burger, Robert William |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description | Thesis (MSc)--Stellenbosch University, 2017. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/102598 |
| institution | Stellenbosch University (South Africa) |
| language | en_ZA |
| last_indexed | 2026-06-10T12:44:59.428Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/102598 Flux balance analysis of Plasmodium falciparum growth and energy metabolism Burger, Robert William Snoep, Jacky L. Eicher, J. Stellenbosch University. Faculty of Science. Dept. of Biochemistry. Flux balance analysis Plasmodium falciparum Metabolic network amino acid Metabolism of Plasmodium falciparum UCTD Thesis (MSc)--Stellenbosch University, 2017. ENGLISH ABSTRACT: Genome-scale network reconstructions serve as an ideal tool for the modeling of large, complex metabolic networks. In this study we use ux-balance analysis to investigate key amino acid dependencies of Plasmodium falciparum growth. Our model was able to produce a realistic ux distribution geared for the optimal production of biomass. We were able to simulate parasite growth in a variety of conditions and assess the favourability of these conditions for optimal growth. To demonstrate the applicability of the model we additionally simulate the response of the model to the introduction of an antimalarial agent, atovaquone. AFRIKAANSE OPSOMMING: Geen opsomming beskikbaar 2017-11-22T12:11:13Z 2017-12-11T10:30:05Z 2018-05-22T03:00:05Z 2017-12 Thesis http://hdl.handle.net/10019.1/102598 en_ZA Stellenbosch University 104 pages : illustrations application/pdf application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | Flux balance analysis Plasmodium falciparum Metabolic network amino acid Metabolism of Plasmodium falciparum UCTD Burger, Robert William Flux balance analysis of Plasmodium falciparum growth and energy metabolism |
| title | Flux balance analysis of Plasmodium falciparum growth and energy metabolism |
| title_full | Flux balance analysis of Plasmodium falciparum growth and energy metabolism |
| title_fullStr | Flux balance analysis of Plasmodium falciparum growth and energy metabolism |
| title_full_unstemmed | Flux balance analysis of Plasmodium falciparum growth and energy metabolism |
| title_short | Flux balance analysis of Plasmodium falciparum growth and energy metabolism |
| title_sort | flux balance analysis of plasmodium falciparum growth and energy metabolism |
| topic | Flux balance analysis Plasmodium falciparum Metabolic network amino acid Metabolism of Plasmodium falciparum UCTD |
| url | http://hdl.handle.net/10019.1/102598 |
| work_keys_str_mv | AT burgerrobertwilliam fluxbalanceanalysisofplasmodiumfalciparumgrowthandenergymetabolism |