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The effect of salsola tuberculatiformis bostchantzev on the androgen and glucocorticoid receptors in prostate cancer cell lines
Thesis (MSc)--Stellenbosch University, 2017.
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| Format: | Thesis |
| Language: | en_ZA |
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Stellenbosch : Stellenbosch University
2017
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| _version_ | 1867614082126839808 |
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| access_status_str | Open Access |
| author | Kelbe, Lisa Suzanne |
| author2 | Swart, P. |
| author_browse | Kelbe, Lisa Suzanne Swart, P. |
| author_facet | Swart, P. Kelbe, Lisa Suzanne |
| author_sort | Kelbe, Lisa Suzanne |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description | Thesis (MSc)--Stellenbosch University, 2017. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/102666 |
| institution | Stellenbosch University (South Africa) |
| language | en_ZA |
| last_indexed | 2026-06-10T12:46:22.874Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/102666 The effect of salsola tuberculatiformis bostchantzev on the androgen and glucocorticoid receptors in prostate cancer cell lines Kelbe, Lisa Suzanne Swart, P. Swart, Amanda C. Stellenbosch University. Faculty of Science. Dept. of Biochemistry. Prostate cancer Androgen receptor -- Effect of salsola tuberculatiformis bostchantzev on Glucocorticoid receptor -- Effect of salsola tuberculatiformis bostchantzev on UCTD Thesis (MSc)--Stellenbosch University, 2017. ENGLISH ABSTRACT: This study describes: 1. The preparation of a biologically active methanol extract from S.tuberculatiformis. 2. The demonstration of biological activity for both the crude S.tuberculatiformis extract and Compound A. 3. The effects of the crude S.tuberculatiformis extract and Compound A on nuclear translocation of the androgen and estrogens receptors in three different prostate cancer cell-lines. 4. Cell viability assays demonstrating the potency (IC50) for Compound A and the crude S.tuberculatiformis extract between the three prostate cancer cell-lines. 5. Caspase assays to demonstrate apoptosis for the crude S.tuberculatiformis extract and Compound A in prostate cancer celllines. AFRIKAANSE OPSOMMING: Hierdie studie beskryf: 1. Die bereiding van 'n biologies-aktiewe kru metanolekstrak uit S.tuberculatiformis. 2. Die bepaling van die biologiese aktiwiteit vir beide die kru metanolekstrak uit S.tuberculatiformis en verbinding A. 3. Die effek van die kru S.tuberculatiformis ekstrak en verbindingA op die translokasie van die glukokortikoïed- en androgeenreseptore in drie verskillende prostaatkanker sel-lyne. 4. Sellewensvatbaarheidstoetse (IC50) met drie prostaatkankersellyne om die toksisiteit van die kru metanolekstrak uit S.tuberculatiformis en verbinding A te bepaal. 5. Kaspasetoetse in prostaatkanker sel-lyne om die apoptotiese effek van die kru metanolekstrak uit S.tuberculatiformis en verbinding A te demonstreer. 2017-05-23T10:10:04Z 2017-12-11T10:38:53Z 2017-05-23T10:10:04Z 2017-12-11T10:38:53Z 2017-12 Thesis http://hdl.handle.net/10019.1/102666 en_ZA Stellenbosch University 178 pages : illustrations application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | Prostate cancer Androgen receptor -- Effect of salsola tuberculatiformis bostchantzev on Glucocorticoid receptor -- Effect of salsola tuberculatiformis bostchantzev on UCTD Kelbe, Lisa Suzanne The effect of salsola tuberculatiformis bostchantzev on the androgen and glucocorticoid receptors in prostate cancer cell lines |
| title | The effect of salsola tuberculatiformis bostchantzev on the androgen and glucocorticoid receptors in prostate cancer cell lines |
| title_full | The effect of salsola tuberculatiformis bostchantzev on the androgen and glucocorticoid receptors in prostate cancer cell lines |
| title_fullStr | The effect of salsola tuberculatiformis bostchantzev on the androgen and glucocorticoid receptors in prostate cancer cell lines |
| title_full_unstemmed | The effect of salsola tuberculatiformis bostchantzev on the androgen and glucocorticoid receptors in prostate cancer cell lines |
| title_short | The effect of salsola tuberculatiformis bostchantzev on the androgen and glucocorticoid receptors in prostate cancer cell lines |
| title_sort | effect of salsola tuberculatiformis bostchantzev on the androgen and glucocorticoid receptors in prostate cancer cell lines |
| topic | Prostate cancer Androgen receptor -- Effect of salsola tuberculatiformis bostchantzev on Glucocorticoid receptor -- Effect of salsola tuberculatiformis bostchantzev on UCTD |
| url | http://hdl.handle.net/10019.1/102666 |
| work_keys_str_mv | AT kelbelisasuzanne theeffectofsalsolatuberculatiformisbostchantzevontheandrogenandglucocorticoidreceptorsinprostatecancercelllines AT kelbelisasuzanne effectofsalsolatuberculatiformisbostchantzevontheandrogenandglucocorticoidreceptorsinprostatecancercelllines |