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Prevalence and risk factors of acute respiratory infection by human respiratory syncytial virus in children at Provincial General Hospital of Bukavu, Democratic Republic of the Congo
Thesis (MMedSc)--Stellenbosch University, 2017.
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Stellenbosch : Stellenbosch University
2017
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| _version_ | 1867613847367450624 |
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| access_status_str | Open Access |
| author | Cihambanya, Landry Kabego |
| author2 | De Beer, Corena |
| author_browse | Cihambanya, Landry Kabego De Beer, Corena |
| author_facet | De Beer, Corena Cihambanya, Landry Kabego |
| author_sort | Cihambanya, Landry Kabego |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description | Thesis (MMedSc)--Stellenbosch University, 2017. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/102699 |
| institution | Stellenbosch University (South Africa) |
| last_indexed | 2026-06-10T12:42:38.497Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/102699 Prevalence and risk factors of acute respiratory infection by human respiratory syncytial virus in children at Provincial General Hospital of Bukavu, Democratic Republic of the Congo Cihambanya, Landry Kabego De Beer, Corena Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Pathology. Medical Virology. Medical virology -- Research Respiratory infections in children -- Congo (Democratic Republic) Human respiratory syncytial virus Acute respiratory infection Lungs -- Diseases -- Congo (Democratic Republic) UCTD Thesis (MMedSc)--Stellenbosch University, 2017. ENGLISH ABSTRACT : Human Respiratory Syncytial Virus (HRSV) is the major cause of acute respiratory infection in children (ARI) and it is responsible for substantial morbidity and mortality, especially in younger children. The present study had two main objectives. The first one was to determine the prevalence of HRSV and non-HRSV ARI in children under the age of 5 years at the Provincial General Hospital of Bukavu (PGHB). The second objective was to analyse factors associated with the risk of ARI to be diagnosed as lower respiratory tract infection (LRTI). A total of 146 children under 5 years visiting the PGHB for ARI between August and December 2016 were recruited. A clinical examination was made and a questionnaire was completed by the parent or the guardian after which a nasopharyngeal swab was performed to collect respiratory fluid. The sample was analysed by a multiplex reverse transcriptase polymerase chain reaction for the detection of 15 different viruses, among which HRSV A and B, Influenza A and B, human Rhinovirus (HRV) A/B/C, Parainfluenza (PIV) viruses 1, 2, 3 and 4, Adenovirus (ADV), Bocavirus, Coronavirus OC43 and 229E/NL63, Enterovirus and human Metapneumovirus. Of 146 samples collected, 84 (57.5%) displayed a positive result of at least one of the 15 viruses. The overall prevalence of HRSV was 21.2%. HRSV A (30, 20.5%) was the virus the most detected, followed by HRV (24, 16.4%), PIV3 (20, 16.6) and ADV (7, 4.79%). The other viruses were detected in three or less cases. There were only 11 (7.5%) of co-infection. In bivariate analyses, HRSV infection, malnutrition, younger age, rural settings, low income and mother illiteracy were associated with the risk of ARI to be diagnosed as LRTI. However, in multivariate analyses, only HRSV infection and younger age predicted LRTI. Children with HRSV infection had 6.45 times higher odds to exhibit LRTI when compared to children without HRSV infection. Older children (by one month) had 6% lower odds of LRTI than younger children (adjusted odds ratio = 0.94, 95% CI: 0.90 – 0.97, p-value = 0.004). AFRIKAANSE OPSOMMING : Respiratoriese sinsitiale virus (RSV) is die hoofoorsaak van akute respiratoriese infeksie (ARI) by kinders en dit is verantwoordelik vir erge morbiditeit en mortaliteit, veral by jonger kinders. Die huidige studie het twee hoofdoelwitte gehad. Die eerste een was om die voorkoms van RSV en nie-RSV ARI in kinders onder die ouderdom van 5 jaar by die Provinsiale Algemene Hospitaal van Bukavu (PGHB) te bepaal. Die tweede doel was om faktore te analiseer wat verband hou met die risiko dat ARI gediagnoseer word as lae lugweginfeksie. 'n Totaal van 146 kinders onder 5 jaar wat die PGHB vir ARI besoek het tussen Augustus en Desember 2016 is gewerf vir die studie. 'n Kliniese ondersoek is gedoen en 'n vraelys is deur die ouer of voog voltooi, waarna respiratoriese vloeistof met behulp van 'n nasofaringeale depper versamel is. Die monster is geanaliseer met behulp van 'n multiplex-omgekeerde transkriptase-polimerase kettingreaksie vir die opsporing van 15 verskillende virusse, waaronder RSV A en B, Influenza A en B, menslike Rhinovirus (HRV) A / B / C, Parainfluenza virus (PIV) 2, 3 en 4, Adenovirus (ADV), Bocavirus, Coronavirus OC43 en 229E / NL63, Enterovirus en menslike Metapneumovirus. Van 146 monsters wat versamel is, is minstens een van die 15 virusse bevestig in 84 (57.5%) gevalle. Die algehele voorkoms van RSV was 21.2%. RSV A (30, 20.5%) was die virus wat die meeste bespeur is, gevolg deur HRV (24, 16.4%), PIV3 (20,16.6) en ADV (7, 4.79%). Die ander virusse is slegs in drie of minder gevalle bevestig. Daar was slegs 11 (7.5%) ko-infeksie. In ʼn twee-veranderlike analise is RSV-infeksie, wanvoeding, jonger ouderdom, landelike woongebiede, lae inkomste en ongeletterdheid in moeders geassosieer met die risiko dat ARI gediagnoseer word as lae lugweginfeksie. In ʼn meer-veranderlike analise het slegs RSV-infeksie en jonger ouderdom lae lugweginfeksie voorspel. Kinders met RSV-infeksie het ʼn 6.45 keer hoër kans gehad om lae lugweginfeksie te vertoon in vergelyking met kinders sonder RSV-infeksie. Ouer kinders (met een maand) het ʼn 6% laer kans gehad op lae lugweginfeksie as jonger kinders (aangepaste kansverhouding = 0.94, 95% CI: 0.90 – 0.97, p-waarde = 0.004). 2017-11-02T12:10:13Z 2017-12-11T10:43:06Z 2017-11-02T12:10:13Z 2017-12-11T10:43:06Z 2017-12 Thesis http://hdl.handle.net/10019.1/102699 Stellenbosch University xii, 70 pages : illustrations (some colour) application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | Medical virology -- Research Respiratory infections in children -- Congo (Democratic Republic) Human respiratory syncytial virus Acute respiratory infection Lungs -- Diseases -- Congo (Democratic Republic) UCTD Cihambanya, Landry Kabego Prevalence and risk factors of acute respiratory infection by human respiratory syncytial virus in children at Provincial General Hospital of Bukavu, Democratic Republic of the Congo |
| title | Prevalence and risk factors of acute respiratory infection by human respiratory syncytial virus in children at Provincial General Hospital of Bukavu, Democratic Republic of the Congo |
| title_full | Prevalence and risk factors of acute respiratory infection by human respiratory syncytial virus in children at Provincial General Hospital of Bukavu, Democratic Republic of the Congo |
| title_fullStr | Prevalence and risk factors of acute respiratory infection by human respiratory syncytial virus in children at Provincial General Hospital of Bukavu, Democratic Republic of the Congo |
| title_full_unstemmed | Prevalence and risk factors of acute respiratory infection by human respiratory syncytial virus in children at Provincial General Hospital of Bukavu, Democratic Republic of the Congo |
| title_short | Prevalence and risk factors of acute respiratory infection by human respiratory syncytial virus in children at Provincial General Hospital of Bukavu, Democratic Republic of the Congo |
| title_sort | prevalence and risk factors of acute respiratory infection by human respiratory syncytial virus in children at provincial general hospital of bukavu democratic republic of the congo |
| topic | Medical virology -- Research Respiratory infections in children -- Congo (Democratic Republic) Human respiratory syncytial virus Acute respiratory infection Lungs -- Diseases -- Congo (Democratic Republic) UCTD |
| url | http://hdl.handle.net/10019.1/102699 |
| work_keys_str_mv | AT cihambanyalandrykabego prevalenceandriskfactorsofacuterespiratoryinfectionbyhumanrespiratorysyncytialvirusinchildrenatprovincialgeneralhospitalofbukavudemocraticrepublicofthecongo |