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Development of a patient-specific unicompartmental knee replacement
Thesis (PhD)--Stellenbosch University, 2018.
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| Other Authors: | |
| Format: | Thesis |
| Language: | en_ZA |
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Stellenbosch : Stellenbosch University
2018
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| _version_ | 1867613794529705984 |
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| access_status_str | Open Access |
| author | Van der Merwe, Johan |
| author2 | Van den Heever, David Jacobus |
| author_browse | Van den Heever, David Jacobus Van der Merwe, Johan |
| author_facet | Van den Heever, David Jacobus Van der Merwe, Johan |
| author_sort | Van der Merwe, Johan |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description | Thesis (PhD)--Stellenbosch University, 2018. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/103819 |
| institution | Stellenbosch University (South Africa) |
| language | en_ZA |
| last_indexed | 2026-06-10T12:41:46.856Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/103819 Development of a patient-specific unicompartmental knee replacement Van der Merwe, Johan Van den Heever, David Jacobus Stellenbosch University. Faculty of Engineering, Dept. of Mechanical and Mechatronic Engineering. Patients -- Knee -- Surgery Surgical implants -- Design Total knee replacement Statistical shape model UCTD Thesis (PhD)--Stellenbosch University, 2018. ENGLISH ABSTRACT: Patient-specific Unicompartmental Knee Replacements (UKRs) could potentially restore an Osteoarthritic (OA) knee closer to its pre-pathological state than off-the-shelf products. Nevertheless, the current state-of-the-art is still heavily reliant on a technician's interpretation and skill in order to reproduce healthy geometries. This dissertation therefore focused on developing a reliable, semi-automated approach to implant design. Inter-patient variability and inter- and intra-observer agreement and reliability was studied for a set of landmarks defined on the distal femur and proximal tibia. This provided necessary input to downstream processes. The variation in a populations' knees was captured by Statistical Shape Models (SSMs), and the subsequent use of a Graphical User Interface (GUI) was investigated to incorporate local constraints as part of sparse SSM estimation. These estimates formed the base of the implants' femoral components, and together with matching metal-backed, motion-guided tibial components were created using automated B-spline parametrisations. Sixteen unseen knees were used as test candidates and it was found that the resulting condyle estimations were sufficiently accurate, while the generated implant components matched normal knee anatomy. Both the GUI-based estimation and the automated design process showed good repeatability. The implant design presented here is ready for pre-clinical testing and evaluation. AFRIKAANSE OPSOMMING: Pasiëntspesifieke Unikomaptementele Knie Vervangings (UKVs) kan moontlik 'n Osteoartritiese (OA) knie nader aan sy voorpatologiese toestand herstel as van-die-rak produkte. Nietemin, die huidige stand-van-die-kuns is steeds sterk afhanklik van die tegnikus se interpretasie en vaardigheid om gesonde geometrieë na te maak. Hierdie proefskrif het dus gefokus op die ontwikkeling van 'n betroubare, semi-automoatiese benadering tot implantaat ontwerp. Inter-pasiënt veranderlikheid en inter- en intra-waarnemer ooreenkoms en betroubaarheid is bestudeer vir 'n stel landmerke wat op die distale femur en proximale tibia gedefinieer is. Dit het die nodige insette vir afstroomprosesse verskaf. Die variasie in 'n populasie se knieë is gevang deur Statistiese Vormmodelle (SVs), en die daaropvolgende gebruik van 'n Grafiese Gebruikerskoppelvlak (GGK) is ondersoek om lokale beperkinge in te sluit as deel van 'n yl SV-skatting. Hierdie skattings het die basis van die implantate se femorale komponente gevorm, en is geskep met behulp van geoutomatiseerde B-spline parametrisasies tesaam met die ooreenstemmende metaalgesteunde, bewegingsgeleide tibiale komponente. Sestien versteekte knieë is as toetskandidate gebruik en daar is bevind dat die resulterende kondiele-skattings akkuraat genoeg was terwyl die gegenereerde implantaat-komponente ooreenstem met normale knie anatomie. Beide die GGK-gebaseerde skattings en die outomatiese ontwerpproses het goeie herhaalbaarheid getoon. Die implantaat ontwerp wat ons hier aanbied is gereed vir voor-kliniese toetsing en evaluering. Doctoral 2018-02-28T17:49:44Z 2018-04-09T07:10:30Z 2018-02-28T17:49:44Z 2018-04-09T07:10:30Z 2018-03 Thesis http://hdl.handle.net/10019.1/103819 en_ZA Stellenbosch University 191 pages : illustrations application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | Patients -- Knee -- Surgery Surgical implants -- Design Total knee replacement Statistical shape model UCTD Van der Merwe, Johan Development of a patient-specific unicompartmental knee replacement |
| title | Development of a patient-specific unicompartmental knee replacement |
| title_full | Development of a patient-specific unicompartmental knee replacement |
| title_fullStr | Development of a patient-specific unicompartmental knee replacement |
| title_full_unstemmed | Development of a patient-specific unicompartmental knee replacement |
| title_short | Development of a patient-specific unicompartmental knee replacement |
| title_sort | development of a patient specific unicompartmental knee replacement |
| topic | Patients -- Knee -- Surgery Surgical implants -- Design Total knee replacement Statistical shape model UCTD |
| url | http://hdl.handle.net/10019.1/103819 |
| work_keys_str_mv | AT vandermerwejohan developmentofapatientspecificunicompartmentalkneereplacement |