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A retrospective review of Listeria monocytogenes infection at Tygerberg Children’s Hospital from 2006 – 2016: is empiric ampicillin still indicated past the early neonatal period
Thesis (MMed)--Stellenbosch University, 2018.
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| Format: | Thesis |
| Language: | en_ZA |
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Stellenbosch : Stellenbosch University, 2018.
2018
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| _version_ | 1867614125558857728 |
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| access_status_str | Open Access |
| author | Oppel, Kim |
| author2 | Finlayson, Heather |
| author_browse | Finlayson, Heather Oppel, Kim |
| author_facet | Finlayson, Heather Oppel, Kim |
| author_sort | Oppel, Kim |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description | Thesis (MMed)--Stellenbosch University, 2018. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/105131 |
| institution | Stellenbosch University (South Africa) |
| language | en_ZA |
| last_indexed | 2026-06-10T12:47:03.084Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| publisher | Stellenbosch : Stellenbosch University, 2018. |
| publisherStr | Stellenbosch : Stellenbosch University, 2018. |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/105131 A retrospective review of Listeria monocytogenes infection at Tygerberg Children’s Hospital from 2006 – 2016: is empiric ampicillin still indicated past the early neonatal period Oppel, Kim Finlayson, Heather Holgate, Sandi Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Paediatrics and Child Health. Listeria monocytogenes -- Treatment Paediatric antibiotic policy Pregnancy -- Complications Neonatal infections UCTD Thesis (MMed)--Stellenbosch University, 2018. ENGLISH ABSTRACT: Background: Ampicillin to treat Listeria Monocytogenes (LM) infection is empirically added to the treatment of infants (<3 months) with suspected sepsis or meningitis. In view of the limited LM cases, paucity of South African data and an ampicillin shortage, we aimed to describe the occurrence of LM infections at Tygerberg Hospital (TBH) with the aim of rationalising the paediatric antibiotic policy. Methods: An 11 year (2006-2016) retrospective descriptive study of children (<13 years) from TBH and referral hospitals with a positive blood or cerebral spinal fluid (CSF) culture for LM was conducted. Results: Of 26 positive cultures for LM, 23 (88%) occurred in infants <3 months of age, all <10 days old. Approximately half (56.5%, 13/23) were born at or referred to TBH. Presentation occurred on the day of delivery in 46% (6/13) and 92% were admitted to the neonatal intensive care unit (NICU), 8/13 (62%) died. Neonates treated at peripheral hospitals had statically higher cerebral spinal fluid examinations (90% vs 31% (p=0.019)), a higher platelet count (239x109/L vs 107x109/L (p=0.004)), lower CRP (64 mg/L vs 137 mg/L (p=0.01)) and a lower mortality rate (0% vs 62% (p=0.002)). The incidence of LM at TBH was 0.04/1000 live births, and 2.3/1000 NICU admissions. Conclusion: As in other countries the local neonatal LM incidence is low. Neonates present in the 1st week of life with severe disease and a high mortality rate. This data supports a change in antibiotic policy, in keeping with international guidelines, limiting empiric ampicillin prescription to infants <1 month old. AFRIKAANS OPSOMMING: Geen opsomming biskikbaar. Masters 2018-11-22T10:04:24Z 2018-12-10T06:33:53Z 2018-11-22T10:04:24Z 2018-12-10T06:33:53Z 2018-12 Thesis http://hdl.handle.net/10019.1/105131 en_ZA Stellenbosch University 15 pages : illustration application/pdf Stellenbosch : Stellenbosch University, 2018. |
| spellingShingle | Listeria monocytogenes -- Treatment Paediatric antibiotic policy Pregnancy -- Complications Neonatal infections UCTD Oppel, Kim A retrospective review of Listeria monocytogenes infection at Tygerberg Children’s Hospital from 2006 – 2016: is empiric ampicillin still indicated past the early neonatal period |
| title | A retrospective review of Listeria monocytogenes infection at Tygerberg Children’s Hospital from 2006 – 2016: is empiric ampicillin still indicated past the early neonatal period |
| title_full | A retrospective review of Listeria monocytogenes infection at Tygerberg Children’s Hospital from 2006 – 2016: is empiric ampicillin still indicated past the early neonatal period |
| title_fullStr | A retrospective review of Listeria monocytogenes infection at Tygerberg Children’s Hospital from 2006 – 2016: is empiric ampicillin still indicated past the early neonatal period |
| title_full_unstemmed | A retrospective review of Listeria monocytogenes infection at Tygerberg Children’s Hospital from 2006 – 2016: is empiric ampicillin still indicated past the early neonatal period |
| title_short | A retrospective review of Listeria monocytogenes infection at Tygerberg Children’s Hospital from 2006 – 2016: is empiric ampicillin still indicated past the early neonatal period |
| title_sort | retrospective review of listeria monocytogenes infection at tygerberg children s hospital from 2006 2016 is empiric ampicillin still indicated past the early neonatal period |
| topic | Listeria monocytogenes -- Treatment Paediatric antibiotic policy Pregnancy -- Complications Neonatal infections UCTD |
| url | http://hdl.handle.net/10019.1/105131 |
| work_keys_str_mv | AT oppelkim aretrospectivereviewoflisteriamonocytogenesinfectionattygerbergchildrenshospitalfrom20062016isempiricampicillinstillindicatedpasttheearlyneonatalperiod AT oppelkim retrospectivereviewoflisteriamonocytogenesinfectionattygerbergchildrenshospitalfrom20062016isempiricampicillinstillindicatedpasttheearlyneonatalperiod |