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Prevalence of non-communicable diseases in adults living with Human Immunodeficiency Virus : an overview of systematic reviews
Thesis (MMed)--Stellenbosch University, 2019.
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| Format: | Thesis |
| Language: | en_ZA |
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Stellenbosch : Stellenbosch University
2019
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| _version_ | 1867614118779813888 |
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| access_status_str | Open Access |
| author | Jaffer, Shahista Mustafa |
| author2 | Young, Taryn |
| author_browse | Jaffer, Shahista Mustafa Young, Taryn |
| author_facet | Young, Taryn Jaffer, Shahista Mustafa |
| author_sort | Jaffer, Shahista Mustafa |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description | Thesis (MMed)--Stellenbosch University, 2019. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/106161 |
| institution | Stellenbosch University (South Africa) |
| language | en_ZA |
| last_indexed | 2026-06-10T12:46:57.306Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2019 |
| publishDateRange | 2019 |
| publishDateSort | 2019 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/106161 Prevalence of non-communicable diseases in adults living with Human Immunodeficiency Virus : an overview of systematic reviews Jaffer, Shahista Mustafa Young, Taryn Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Global Health. Epidemiology and Biostatistics. HIV-positive persons -- Health risk assessment Chronic diseases -- Transmission Comorbidity Highly active antiretroviral therapy Systematic reviews (Medical research) UCTD Thesis (MMed)--Stellenbosch University, 2019. ENGLISH SUMMARY : Background: Non-communicable diseases (NCD’s) are on the rise in patients with HIV and this has been partly attributed to the increasing use of Antiretroviral therapy (ART). Our aim was to consolidate findings on prevalence of NCD in those with HIV, from systematic reviews, to inform the existing body of research and provide evidence to inform planning of healthcare services. Methods: We undertook a comprehensive search in February 2018, with no date limitations, in 7 databases to identify systematic reviews on the prevalence of NCD’s in HIV patients on ART. We included systematic reviews with participants over the age of 13years who were on ART and had one or more of the specified NCD’s including diabetes mellitus type 2, hypertension, dyslipidemia and depression. We then assessed the quality of these systematic reviews using the AMSTAR 2 tool and extracted prevalence’s of the NCD’s from each one of them. Results: We identified 10 systematic reviews meeting our inclusion criteria of which 3 are ongoing. The methodological quality of the seven systematic reviews assessed varied in many aspects. Only one systematic review assessed prevalence of multi-morbidity defined as the presence of two or more NCD’s in people living with HIV (PLHIV) which ranged from 8.4% to 47%, the remaining six only assessed the prevalence of comorbidity of any one NCD in PLHIV. Diabetes mellitus type 2 had the lowest prevalence especially in African countries and it ranged between 7% to 48.6% globally while dyslipidemia had the highest prevalence globally ranging from 6.3% to 100%. Depression in PLHIV who were on ART was considerably high ranging from 25.81% to 64% while hypertension ranged from as low as 4.0% to as high as 67.0%. Conclusions: This overview highlights that NCD’s are highly prevalent in PLHIV on ART. There is a lack of systematic reviews and primary studies focusing on multi-morbidity in the HIV population on ART. PROSPERO registration number - CRD42018104420. AFRIKAANSE OPSOMMING : Geen opsomming beskikbaar. 2019-02-18T21:20:28Z 2019-04-17T08:31:46Z 2019-02-18T21:20:28Z 2019-04-17T08:31:46Z 2019-04 Thesis http://hdl.handle.net/10019.1/106161 en_ZA Stellenbosch University 98 pages ; illustrations, includes annexures application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | HIV-positive persons -- Health risk assessment Chronic diseases -- Transmission Comorbidity Highly active antiretroviral therapy Systematic reviews (Medical research) UCTD Jaffer, Shahista Mustafa Prevalence of non-communicable diseases in adults living with Human Immunodeficiency Virus : an overview of systematic reviews |
| title | Prevalence of non-communicable diseases in adults living with Human Immunodeficiency Virus : an overview of systematic reviews |
| title_full | Prevalence of non-communicable diseases in adults living with Human Immunodeficiency Virus : an overview of systematic reviews |
| title_fullStr | Prevalence of non-communicable diseases in adults living with Human Immunodeficiency Virus : an overview of systematic reviews |
| title_full_unstemmed | Prevalence of non-communicable diseases in adults living with Human Immunodeficiency Virus : an overview of systematic reviews |
| title_short | Prevalence of non-communicable diseases in adults living with Human Immunodeficiency Virus : an overview of systematic reviews |
| title_sort | prevalence of non communicable diseases in adults living with human immunodeficiency virus an overview of systematic reviews |
| topic | HIV-positive persons -- Health risk assessment Chronic diseases -- Transmission Comorbidity Highly active antiretroviral therapy Systematic reviews (Medical research) UCTD |
| url | http://hdl.handle.net/10019.1/106161 |
| work_keys_str_mv | AT jaffershahistamustafa prevalenceofnoncommunicablediseasesinadultslivingwithhumanimmunodeficiencyvirusanoverviewofsystematicreviews |