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Effect of monomer distribution on the efficiency of poly(styrene-co-maleic acid) lipid particle (SMALP) formation
Thesis (MSc)--Stellenbosch University, 2020.
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| Format: | Thesis |
| Language: | en_ZA |
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Stellenbosch : Stellenbosch University
2020
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| _version_ | 1867613732265263104 |
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| access_status_str | Open Access |
| author | Cunningham, Randy Duwayne |
| author2 | Klumperman, Bert |
| author_browse | Cunningham, Randy Duwayne Klumperman, Bert |
| author_facet | Klumperman, Bert Cunningham, Randy Duwayne |
| author_sort | Cunningham, Randy Duwayne |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description | Thesis (MSc)--Stellenbosch University, 2020. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/108341 |
| institution | Stellenbosch University (South Africa) |
| language | en_ZA |
| last_indexed | 2026-06-10T12:40:49.380Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/108341 Effect of monomer distribution on the efficiency of poly(styrene-co-maleic acid) lipid particle (SMALP) formation Cunningham, Randy Duwayne Klumperman, Bert Pfukwa, Rueben Stellenbosch University. Faculty of Science. Dept. of Chemistry and Polymer Science. Copolymers Polymerization Styrene Maleic acid UCTD Thesis (MSc)--Stellenbosch University, 2020. ENGLISH ABSTRACT: This body of work entails the synthesis and characterisation of non-alternating poly(styrene-co-maleic anhydride) copolymers via an iterative RAFT technique. This approach affords copolymers which are characterised by a narrow chemical composition distribution. After basic hydrolysis, the synthesised copolymers were then employed in lipid solubilization studies in order to evaluate their efficiency in styrene-maleic acid lipid particle (SMALP) formation. Relative to commercially available poly(styrene-co-maleic anhydride), the RAFT-made polymers yielded SMALPs with improved thermal stabilities and were found to insert more efficiently into lipid monolayers. The improved solubilisation efficiency of the RAFT-made polymers was ascribed to the homogenous distribution of monomer units throughout the polymer backbone. This arrangement is said to promote uncoiling of the styrene-rich hydrophobic core allowing access to the specific conformation required for nanodisc stabilisation. AFRIKAANSE OPSOMMING: Hierdie werkstuk behels die sintese en karakterisering van nie-afwisselende poli (stireen-ko-maleïne-anhidried) kopolimere via 'n iteratiewe RAFT-tegniek. Hierdie benadering bied kopolimere aan wat gekenmerk word deur 'n nou verspreiding van chemiese samestellings. Na basiese hidrolise is die gesintetiseerde kopolimere dan in lipiedoplosbaarheidstudies gebruik om hul doeltreffendheid in die vorming van stireenmaleïnezuur-lipieddeeltjies (SMALP) te evalueer. Met betrekking tot die kommersieel beskikbare poli(stireen-ko-maleïne-anhidried) het die RAFT-vervaardigde polimere SMALP's met verbeterde termiese stabiliteit opgelewer, en dit voeg meer doeltreffend in die lipiedmonolaag. Die verbeterde oplosbaarheid van die RAFT-vervaardigde polimere word toegeskryf aan die homogene verspreiding van monomeereenhede deur die polimeer ruggraat. Daar word beweer dat hierdie rangskikking die afwikkeling van die stireenryke hidrofobiese kern bevorder, waardeur toegang tot die spesifieke konstruksie benodig word vir nanodisk stabilisering. Masters 2020-01-15T14:44:01Z 2020-04-28T15:10:22Z 2020-01-15T14:44:01Z 2020-04-28T15:10:22Z 2020-01 Thesis http://hdl.handle.net/10019.1/108341 en_ZA Stellenbosch University xiii, 74 pages : illustrations application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | Copolymers Polymerization Styrene Maleic acid UCTD Cunningham, Randy Duwayne Effect of monomer distribution on the efficiency of poly(styrene-co-maleic acid) lipid particle (SMALP) formation |
| title | Effect of monomer distribution on the efficiency of poly(styrene-co-maleic acid) lipid particle (SMALP) formation |
| title_full | Effect of monomer distribution on the efficiency of poly(styrene-co-maleic acid) lipid particle (SMALP) formation |
| title_fullStr | Effect of monomer distribution on the efficiency of poly(styrene-co-maleic acid) lipid particle (SMALP) formation |
| title_full_unstemmed | Effect of monomer distribution on the efficiency of poly(styrene-co-maleic acid) lipid particle (SMALP) formation |
| title_short | Effect of monomer distribution on the efficiency of poly(styrene-co-maleic acid) lipid particle (SMALP) formation |
| title_sort | effect of monomer distribution on the efficiency of poly styrene co maleic acid lipid particle smalp formation |
| topic | Copolymers Polymerization Styrene Maleic acid UCTD |
| url | http://hdl.handle.net/10019.1/108341 |
| work_keys_str_mv | AT cunninghamrandyduwayne effectofmonomerdistributionontheefficiencyofpolystyrenecomaleicacidlipidparticlesmalpformation |