Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
Alkaloidal constituents of Crinum variabile and Crinum paludosum, two southern African Amaryllidaceae species
Thesis (MSc)--Stellenbosch University, 2020.
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | en_ZA |
| Published: |
Stellenbosch : Stellenbosch University
2020
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613900080414720 |
|---|---|
| access_status_str | Open Access |
| author | Steyn, Kim |
| author2 | Van Otterlo, Willem A. L. |
| author_browse | Steyn, Kim Van Otterlo, Willem A. L. |
| author_facet | Van Otterlo, Willem A. L. Steyn, Kim |
| author_sort | Steyn, Kim |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description | Thesis (MSc)--Stellenbosch University, 2020. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/108362 |
| institution | Stellenbosch University (South Africa) |
| language | en_ZA |
| last_indexed | 2026-06-10T12:43:29.289Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/108362 Alkaloidal constituents of Crinum variabile and Crinum paludosum, two southern African Amaryllidaceae species Steyn, Kim Van Otterlo, Willem A. L. De Villiers, Andre J. Stellenbosch University. Faculty of Science. Dept. of Chemistry and Polymer Science. Amaryllidaceae Alkaloids Crinum Crinum paludosum Thesis (MSc)--Stellenbosch University, 2020. ENGLISH ABSTRACT: The extraction of dried bulbs of Crinum variabile and subsequent targeted fractionation led to the isolation of lycorine, 1,2-O,O-diacetyllycorine, 2-O-acetyllycorine, 1-O-acetyllycorine, a diastereomeric mixture of haemanthidine and 6-epihaemanthidine, bulbispermine and criwelline. HPLC-MS/MS analysis of the extract was carried out, providing information regarding other alkaloidal constituents of C. variabile. The isolation of lycorine, as well as a brief HPLC-MS/MS dereplication study was carried out on an extract of Crinum paludosum, allowing for the tentative identification of ten alkaloidal constituents therein, with five alkaloids remaining unidentified. A brief synthetic study was carried out on higginsianins A and B, resulting in the generation of some analogues thereof. These included acetylated analogues of both, as well as bromination products of higginsianin A, and reductive hydrogenation and epoxidation products of higginsianin B. AFRIKAANSE OPSOMMING: Ekstraksie van gedroogde Crinum variabile blombolle en die daaropvolgende fraksionering het likorien, 1,2-di-O-asetiellikorien, 2-O-asetiellikorien, 1-O-asetiellikorien, ‘n mengsel van haemantidien en 6-epi-haemantidien, bulbespermien en kriwelien opgelewer. HPLC-MS/MS analise van die C. var. ekstrak het adisionele informasie van ander alkaloïde tot gevolge gehad. Isolasie van likorien asook ‘n kort HPLC-MS/MS analise van ‘n ekstrak van Crinum paludosum het tot gevolg gehad dat tien alkaloïde tentatief geidentifiseer kon word met nog vyf wat nie geidentifiseer kon word nie. ‘n Kort sintetise studie op higginsiansins A en B was uitgevoer en het gelei tot die isolasie van die geasetileerde higgginsiansins A en B, die gebromeerde analoog van higginsiansin A, die hidrogeneerde higginsiansin B en die epoksineringsproduk van higginsiansin B. Masters 2020-02-26T00:10:02Z 2020-04-28T15:10:55Z 2020-02-26T00:10:02Z 2020-04-28T15:10:55Z 2020-03 Thesis http://hdl.handle.net/10019.1/108362 en_ZA Stellenbosch University 143 pages application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | Amaryllidaceae Alkaloids Crinum Crinum paludosum Steyn, Kim Alkaloidal constituents of Crinum variabile and Crinum paludosum, two southern African Amaryllidaceae species |
| title | Alkaloidal constituents of Crinum variabile and Crinum paludosum, two southern African Amaryllidaceae species |
| title_full | Alkaloidal constituents of Crinum variabile and Crinum paludosum, two southern African Amaryllidaceae species |
| title_fullStr | Alkaloidal constituents of Crinum variabile and Crinum paludosum, two southern African Amaryllidaceae species |
| title_full_unstemmed | Alkaloidal constituents of Crinum variabile and Crinum paludosum, two southern African Amaryllidaceae species |
| title_short | Alkaloidal constituents of Crinum variabile and Crinum paludosum, two southern African Amaryllidaceae species |
| title_sort | alkaloidal constituents of crinum variabile and crinum paludosum two southern african amaryllidaceae species |
| topic | Amaryllidaceae Alkaloids Crinum Crinum paludosum |
| url | http://hdl.handle.net/10019.1/108362 |
| work_keys_str_mv | AT steynkim alkaloidalconstituentsofcrinumvariabileandcrinumpaludosumtwosouthernafricanamaryllidaceaespecies |