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Clinical presentation and treatment outcomes of infants with tuberculosis in Cape Town, South Africa
Thesis (MMed)--Stellenbosch University, 2020.
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| Format: | Thesis |
| Language: | en_ZA |
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Stellenbosch : Stellenbosch University
2020
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| _version_ | 1867613998464106496 |
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| access_status_str | Open Access |
| author | Aryao, Ruth |
| author2 | Bekker, Adrie |
| author_browse | Aryao, Ruth Bekker, Adrie |
| author_facet | Bekker, Adrie Aryao, Ruth |
| author_sort | Aryao, Ruth |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description | Thesis (MMed)--Stellenbosch University, 2020. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/109051 |
| institution | Stellenbosch University (South Africa) |
| language | en_ZA |
| last_indexed | 2026-06-10T12:45:01.662Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/109051 Clinical presentation and treatment outcomes of infants with tuberculosis in Cape Town, South Africa Aryao, Ruth Bekker, Adrie Dramowski, Angela Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Paediatrics and Child Health. Tuberculosis in children Tuberculin test Tuberculosis source case Paediatric tuberculosis UCTD Thesis (MMed)--Stellenbosch University, 2020. ENGLISH ABSTRACT: Introduction: Limited data are available regarding the presentation, clinical course and outcome of infants (<12 months of age) treated for drug-susceptible tuberculosis. Methods: Infants with tuberculosis admitted at Tygerberg, Khayelitsha District and Brooklyn Chest Hospitals (March 2014-March 2015) were prospectively enrolled with follow-up evaluations at 3- and 6-months post-treatment initiation. Results: Among 39 infants diagnosed with tuberculosis, 21 (54%) had known contact with an adult tuberculosis source case. The median age of infants at diagnosis was 6 months (IQR 3-7) and median weight 5.2 kg (IQR 3.2–10.2). Twenty-two of 39 (56%) were exposed to HIV of whom 5 were HIV infected. Growth faltering (25; 68%) and persistent cough (13; 33%) were frequent presenting symptoms. Most infants were diagnosed with intrathoracic tuberculosis (37/39; 95%) while 5% had disseminated tuberculosis and (14/39; 36%) had culture-confirmed tuberculosis. Alveolar opacification (22; 56%), mediastinal lymphadenopathy (13; 33%) and large airway obstruction (8; 20%) were common chest radiography findings. Tuberculosis treatment outcomes were favourable in 33/39 (85%) infants, but with additional intervention 37 (95%) completed treatment. Conclusions: Intrathoracic tuberculosis was the predominant disease type and one-third of the cohort had culture-confirmed tuberculosis. More than half on the infants were born to a mother with HIV. An adult tuberculosis source case was identifiable in half of the cases. Additional interventions improved favourable treatment outcomes. "Geen opsomming beskikbaar" Masters 2020-11-16T12:14:54Z 2021-01-31T18:20:25Z 2020-11-16T12:14:54Z 2021-01-31T18:20:25Z 2020-12 Thesis http://hdl.handle.net/10019.1/109051 en_ZA Stellenbosch University 14 pages application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | Tuberculosis in children Tuberculin test Tuberculosis source case Paediatric tuberculosis UCTD Aryao, Ruth Clinical presentation and treatment outcomes of infants with tuberculosis in Cape Town, South Africa |
| title | Clinical presentation and treatment outcomes of infants with tuberculosis in Cape Town, South Africa |
| title_full | Clinical presentation and treatment outcomes of infants with tuberculosis in Cape Town, South Africa |
| title_fullStr | Clinical presentation and treatment outcomes of infants with tuberculosis in Cape Town, South Africa |
| title_full_unstemmed | Clinical presentation and treatment outcomes of infants with tuberculosis in Cape Town, South Africa |
| title_short | Clinical presentation and treatment outcomes of infants with tuberculosis in Cape Town, South Africa |
| title_sort | clinical presentation and treatment outcomes of infants with tuberculosis in cape town south africa |
| topic | Tuberculosis in children Tuberculin test Tuberculosis source case Paediatric tuberculosis UCTD |
| url | http://hdl.handle.net/10019.1/109051 |
| work_keys_str_mv | AT aryaoruth clinicalpresentationandtreatmentoutcomesofinfantswithtuberculosisincapetownsouthafrica |