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Graph-based semi-supervised learning for the detection of potential disease causing genes
Thesis (PhD)--Stellenbosch University, 2020.
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| Format: | Thesis |
| Language: | en_ZA |
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Stellenbosch : Stellenbosch University
2020
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| _version_ | 1867614134201221120 |
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| access_status_str | Open Access |
| author | Van Zyl, G. |
| author2 | Van Vuuren, J. H. |
| author_browse | Van Vuuren, J. H. Van Zyl, G. |
| author_facet | Van Vuuren, J. H. Van Zyl, G. |
| author_sort | Van Zyl, G. |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description | Thesis (PhD)--Stellenbosch University, 2020. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/109105 |
| institution | Stellenbosch University (South Africa) |
| language | en_ZA |
| last_indexed | 2026-06-10T12:47:12.516Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/109105 Graph-based semi-supervised learning for the detection of potential disease causing genes Van Zyl, G. Van Vuuren, J. H. Stellenbosch University. Faculty of Engineering. Dept. of Industrial Engineering. Bioinformatics Protein-protein interaction network Linkage mapping (Genetics) Heterogeneous distributed computing systems UCTD Thesis (PhD)--Stellenbosch University, 2020. ENGLISH ABSTRACT: AbstractIt is widely believed that almost all diseases are, to some extent, influenced by individuals’ geneticmake-up. Ample insight into this relationship may usher in a new age where preventative,precision medicine is the norm. The identification of human genes associated with diseases(disease genesin short) is a central step in the realisation of this ambition. The developmentof computational approaches aimed at identifying putative disease genes among a large pool ofcandidates — so as to reduce the number of alternatives to be explored in further validationexperiments and functional studies — has, therefore, become one of the fundamental problemsin bioinformatics.In the realm of bioinformatics, disease gene classification is primarily based on the principlethat “the network neighbour of a disease gene is likely to cause the same or a similar disease.”In this dissertation, a novel computational approach to the disease gene identification problemis proposed. This methodological framework utilises the aforementioned principle and exploitsboth the modular nature of biological networks and the abundance of available data related tothe similarities between genes within a semi-supervised machine learning paradigm.The proposed disease gene identification methodology is demonstrated practically and found toexhibit significant classification abilities. In addition, the framework is successfully applied toobtain ranked sets of putative disease gene predictions — a number of which are verified byretrieving evidence of their involvement in the origins of diseases from the literature. AFRIKAANSE OPSOMMING: Daar word algemeen geglo dat bykans alle siektes tot ’n sekere mate deur die genetiese samestel-ling van individue be ̈ınvloed word. Goeie insig in hierdie verwantskap kan na ’n nuwe tydvak leiwaar voorkomende, presiesie-medisyne die norm is. Die identifikasie van menslike gene wat metsiektes (siekte-genein kort) verbind word, is ’n sentrale stap in die verwesenliking van hierdieideaal. Die ontwikkeling van berekeningsbenaderings wat daarop gemik is om vermeende siekte-gene tussen ’n groot aantal kandidate te identifiseer — om sodoende die aantal alternatiewe watin verdere valideringseksperimente en funksionele studies ondersoek moet word, te verminder —is dus een van die fundamentele probleme in bioinformatika.Op die gebied van bioinformatika is die klassifikasie van siekte-gene hoofsaaklik gebaseer opdie beginsel dat “die netwerkbuurgeen van ’n siekte-geen waarskynlik dieselfde of ’n soortge-lyke siekte sal veroorsaak.” In hierdie proefskrif word ’n nuwe berekeningsbenadering tot dieidentifikasieprobleem van die siekte-gene daargestel. Hierdie metodologiese raamwerk maak ge-bruik van die bogenoemde beginsel en benut beide die modulˆere aard van biologiese netwerkeen die oorvloed beskikbare data wat verband hou met die ooreenkomste tussen gene binne ’nsemi-toesighoudende masjienleerparadigma.Die voorgestelde metodologie vir die identifikasie van siekte-gene word prakties gedemonstreeren daar word bevind dat die metodologie oor betekenisvolle klassifikasievermo ̈e beskik. Daar-benewens word die raamwerk suksesvol toegepas om rangordes van vermeende siekte-gene daarte stel, waarvan ’n aantal geverifieer word deur bewyse van hul deelname aan die oorsprong vansiektes uit die literatuur te staaf. Doctoral 2020-10-07T18:20:55Z 2021-01-31T19:35:33Z 2020-10-07T18:20:55Z 2021-01-31T19:35:33Z 2020-12 Thesis http://hdl.handle.net/10019.1/109105 en_ZA Stellenbosch University 411 pages : illustrations application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | Bioinformatics Protein-protein interaction network Linkage mapping (Genetics) Heterogeneous distributed computing systems UCTD Van Zyl, G. Graph-based semi-supervised learning for the detection of potential disease causing genes |
| title | Graph-based semi-supervised learning for the detection of potential disease causing genes |
| title_full | Graph-based semi-supervised learning for the detection of potential disease causing genes |
| title_fullStr | Graph-based semi-supervised learning for the detection of potential disease causing genes |
| title_full_unstemmed | Graph-based semi-supervised learning for the detection of potential disease causing genes |
| title_short | Graph-based semi-supervised learning for the detection of potential disease causing genes |
| title_sort | graph based semi supervised learning for the detection of potential disease causing genes |
| topic | Bioinformatics Protein-protein interaction network Linkage mapping (Genetics) Heterogeneous distributed computing systems UCTD |
| url | http://hdl.handle.net/10019.1/109105 |
| work_keys_str_mv | AT vanzylg graphbasedsemisupervisedlearningforthedetectionofpotentialdiseasecausinggenes |