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The Prevalence of Propofol Contamination in the Tygerberg Theatre Complex
Thesis (MMed)--Stellenbosch University, 2020.
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| Format: | Thesis |
| Language: | en_ZA |
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Stellenbosch : Stellenbosch University
2020
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| _version_ | 1867613889708949504 |
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| access_status_str | Open Access |
| author | Drude, Carmen |
| author2 | Johnson, Marianne |
| author_browse | Drude, Carmen Johnson, Marianne |
| author_facet | Johnson, Marianne Drude, Carmen |
| author_sort | Drude, Carmen |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description | Thesis (MMed)--Stellenbosch University, 2020. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/109219 |
| institution | Stellenbosch University (South Africa) |
| language | en_ZA |
| last_indexed | 2026-06-10T12:43:19.203Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/109219 The Prevalence of Propofol Contamination in the Tygerberg Theatre Complex Drude, Carmen Johnson, Marianne Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Anaesthesiology and Critical Care. UCTD Intravenous anesthesia Propofol -- Contamination Operative wound infections Contamination Thesis (MMed)--Stellenbosch University, 2020. ENGLISH ABSTRACT: Propofol is a widely used intravenous anaesthetic agent. Soon after its introduction into the market, propofol-related postoperative infections were reported. It was determined that the emulsion supports growth and manufacturers provided strict aseptic guidelines with regards to propofol usage, but it has been shown that clinicians in South Africa do not adhere to these guidelines. The primary objective of our observational study was to determine the prevalence of contamination of syringes containing propofol (Fresenius’ Propoven® 1%, Fresenius Kabi, Sweden) in the Tygerberg Hospital Theatre Complex. Samples of syringes containing propofol were collected from various randomised operating theatres over a period of 15 days and specimens cultured and tested for growth of organisms. The secondary objective was to differentiate between contamination occurring in e mergency and elective surgery operating theatres and investigate the difference in propofol contamination when used by junior versus more senior anaesthetists. We demonstrated an unacceptably high propofol contamination prevalence of 41.8% (95% CI: 32.5%, 51.6%). Coagulase negative staphylococcus (CONS) was the most prevalent organism. Overall, 58.18% of samples demonstrated no growth after 2 days. Regarding our secondary objective, there was no statistically significant difference regarding the prevalence of propofol contamination of samples taken from the emergency and elective operating theatres (p = 0.95; risk ratio 1.02; 95% CI: 0.55; 1.89). Propofol syringes handled by senior versus junior anaesthetists revealed a similar result (p = 0.65; risk ratio 0.90; 95% CI: 0.58; 1.41). CONS are often contaminants and the bulk of organisms we cultured are non-pathogenic in healthyhosts but can be lethal in immunocompromised patients. Presence of commensals is also a warning that any other pathogens (including viruses) that may be present on the anaesthetist’s hands or in the environment may also contaminate the propofol. The presence of human commensals as well as environmental organisms in the propofol syringes are avoidable and a zero-contamination rate should be aspired to in all interactions with patients. AFRIKAANSE OPSOMMING: Propofol word tans algemeen as intraveneuse narkosemiddel gebruik. Propofol verwante postoperatiewe infeksies is egter gou nadat die middel bekendgestel is gerapporteer. Organismes kan groei in die emulsie en die vervaardigers het streng aseptiese riglyne vir die gebruik van propofol daargestel. Dit blyk egter dat praktisyns in Suid-Afrika nie die riglyne volg nie. Die primêre doel van ons beskrywende studie was om die prevalensie van kontaminasie van spuite met propofol (Fresenius Propoven® 1%, Fresenius Kabi, Swede) in die Tygerberg Hospitaal Teaterkompleks te bepaal. Monsters van spuite met propofol is versamel van verskeie gerandomiseerde operasieteaters oor ‘n periode van 15 dae. Die monsters is gekweek en evalueer vir die groei van organismes. Die sekondêre doel was om te onderskei tussen kontaminasie in teaters waar nood en elektiewe chirurgie uitgevoer word en om te bepaal of daar ‘n verskil in propofol kontaminasie is tussen junior en meer senior narkose personeel. Ons het ‘n onaanvaarbare hoë prevalensie van propofol kontaminasie van 41.8% (95% CI: 32.5%, 51.6%) gevind. Koagulase negatiewe stafilokokki was die mees prevalente organisme. Geen groei is gevind in 58.18% van die monsters na 2 dae. Wat betref ons sekondêre doel, was daar geen statisties beduidende verskil in die prevalensie van propofol kontaminasie in die monsters geneem in die nood en elektiewe teaters nie (p = 0.95; risk ratio 1.02; 95% CI: 0.55; 1.89). Daar was ook geen verskil in monsters van spuite gebruik deur junior en meer senior narkose personeel nie (p = 0.65; risk ratio 0.90; 95% CI: 0.58; 1.41). Koagulase negatiewe stafilokokki is dikwels kontaminante en die meeste van die organismes wat onsgekweek het is nie patogenies in normale gashere nie. Dit kan egter dodelik wees in pasiënte wat imuunkompromiseerd is. Kontaminasie met kommensale organismes dien as a waarskuwing dat enige patogene (insluitend virusse) op die narkotiseur se hande of in die omgewing in die propofol mag land. Die teenwoordigheid van menslike kommensale organismes sowel as omgewings organismes in die propofol spuite is voorkombaar. Daar moet gestreef word na geen kontaminasie in alle interaksies met pasiënte. Masters 2020-11-20T13:04:12Z 2021-01-31T19:40:05Z 2020-11-20T13:04:12Z 2021-01-31T19:40:05Z 2020-12 Thesis http://hdl.handle.net/10019.1/109219 en_ZA Stellenbosch University 36 pages application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | UCTD Intravenous anesthesia Propofol -- Contamination Operative wound infections Contamination Drude, Carmen The Prevalence of Propofol Contamination in the Tygerberg Theatre Complex |
| title | The Prevalence of Propofol Contamination in the Tygerberg Theatre Complex |
| title_full | The Prevalence of Propofol Contamination in the Tygerberg Theatre Complex |
| title_fullStr | The Prevalence of Propofol Contamination in the Tygerberg Theatre Complex |
| title_full_unstemmed | The Prevalence of Propofol Contamination in the Tygerberg Theatre Complex |
| title_short | The Prevalence of Propofol Contamination in the Tygerberg Theatre Complex |
| title_sort | prevalence of propofol contamination in the tygerberg theatre complex |
| topic | UCTD Intravenous anesthesia Propofol -- Contamination Operative wound infections Contamination |
| url | http://hdl.handle.net/10019.1/109219 |
| work_keys_str_mv | AT drudecarmen theprevalenceofpropofolcontaminationinthetygerbergtheatrecomplex AT drudecarmen prevalenceofpropofolcontaminationinthetygerbergtheatrecomplex |