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Drug repurposing and optimisation to improve tuberculosis treatment
Thesis (PhD)--Stellenbosch University, 2021.
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| Other Authors: | |
| Format: | Thesis |
| Language: | en_ZA |
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Stellenbosch : Stellenbosch University
2021
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| _version_ | 1867613875162054656 |
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| access_status_str | Open Access |
| author | Abulfathi, Ahmed Aliyu |
| author2 | Svensson, Elin M. |
| author_browse | Abulfathi, Ahmed Aliyu Svensson, Elin M. |
| author_facet | Svensson, Elin M. Abulfathi, Ahmed Aliyu |
| author_sort | Abulfathi, Ahmed Aliyu |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description | Thesis (PhD)--Stellenbosch University, 2021. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/110465 |
| institution | Stellenbosch University (South Africa) |
| language | en_ZA |
| last_indexed | 2026-06-10T12:43:05.531Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/110465 Drug repurposing and optimisation to improve tuberculosis treatment Abulfathi, Ahmed Aliyu Svensson, Elin M. Reuter, Helmuth Diacon, Andreas H. Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Medicine: Clinical Pharmacology. UCTD Rifampicin Tuberculosis -- Treatment Pharmacokinetics Tuberculosis vaccines Pulmonary tuberculosis Thesis (PhD)--Stellenbosch University, 2021. ENGLISH ABSTRACT: Tuberculosis, a leading infectious cause of mortality, morbidity, and reduced quality of life with loss of income, remains a huge public health burden particularly in resource-limited settings. The golden thread throughout this dissertation, was improving tuberculosis treatment through repurposing and optimisation of existing medicines. For that purpose, we sought to improve our understanding of the pharmacokinetics and pharmacodynamics of selected anti-tuberculosis drugs. AFRIKAANSE OPSOMMING: Tuberkulose, ‘n hoofoorsaak van infeksiesiekte mortaliteit, morbiditeit en verlaagte lewenskwaliteit met verlies aan inkomste, bly ‘n enorme publieke gesondheidslas, veral in omgewings met beperkte hulpbronne. Ons het met hierdie tesis deurlopend beoog om tuberkulose behandeling deur die heroormerking en optimisering van bestaande medisynes te verbeter. Ten einde hierdie doel te bereik, het ons dit ten doel gestel om ons begrip van die farmakokinetika en farmakodinamika van gekose teen-tuberkulose middels te bevorder. Doctoral 2021-05-18T08:00:28Z 2021-05-18T08:00:28Z 2021-03 Thesis http://hdl.handle.net/10019.1/110465 en_ZA Stellenbosch University 228 pages application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | UCTD Rifampicin Tuberculosis -- Treatment Pharmacokinetics Tuberculosis vaccines Pulmonary tuberculosis Abulfathi, Ahmed Aliyu Drug repurposing and optimisation to improve tuberculosis treatment |
| title | Drug repurposing and optimisation to improve tuberculosis treatment |
| title_full | Drug repurposing and optimisation to improve tuberculosis treatment |
| title_fullStr | Drug repurposing and optimisation to improve tuberculosis treatment |
| title_full_unstemmed | Drug repurposing and optimisation to improve tuberculosis treatment |
| title_short | Drug repurposing and optimisation to improve tuberculosis treatment |
| title_sort | drug repurposing and optimisation to improve tuberculosis treatment |
| topic | UCTD Rifampicin Tuberculosis -- Treatment Pharmacokinetics Tuberculosis vaccines Pulmonary tuberculosis |
| url | http://hdl.handle.net/10019.1/110465 |
| work_keys_str_mv | AT abulfathiahmedaliyu drugrepurposingandoptimisationtoimprovetuberculosistreatment |