Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
Chromosomal aberrations in the Xhosa schizophrenia population
Thesis (PhD (Psychiatry))--Stellenbosch University, 2008.
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Stellenbosch : Stellenbosch University
2008
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613925288181760 |
|---|---|
| access_status_str | Open Access |
| author | Koen, Liezl |
| author2 | Niehaus, Daniel Jan Hendrik |
| author_browse | Koen, Liezl Niehaus, Daniel Jan Hendrik |
| author_facet | Niehaus, Daniel Jan Hendrik Koen, Liezl |
| author_sort | Koen, Liezl |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description | Thesis (PhD (Psychiatry))--Stellenbosch University, 2008. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/1189 |
| institution | Stellenbosch University (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:43:53.285Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2008 |
| publishDateRange | 2008 |
| publishDateSort | 2008 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/1189 Chromosomal aberrations in the Xhosa schizophrenia population Koen, Liezl Niehaus, Daniel Jan Hendrik De Jong, Greetje Stellenbosch University. Faculty of Health Sciences. Dept. of Psychiatry. Schizophrenia -- Genetic aspects Morphology Chromosome 22 Xhosa schizophrenia patients Chromosomal aberrations Xhosa (African people) -- Mental health Human chromosome abnormalities Dissertations -- Psychiatry Theses -- Psychiatry Thesis (PhD (Psychiatry))--Stellenbosch University, 2008. BACKGROUND: Schizophrenia is a heterogeneous illness resulting from complex gene-environment interplay. The majority of molecular genetic work done has involved Caucasian populations, with studies in these and Asian populations showing 2-32% of sufferers to have chromosomal aberrations. So far the discovery of a specific susceptibility mechanism or gene still eludes us, but the use of endophenotypes is advocated as a useful tool in this search. No cytogenetic studies of this nature have been reported in any African schizophrenia population. AIM: The aim of the study was to combine genotypic and phenotypic data, collected in a homogenous population in a structured manner, with the hope of characterising an endophenotype that could be used for more accurate identification of individuals with possible chromosomal abnormalities. METHODOLOGY: A structured clinical interview was conducted on 112 Xhosa schizophrenia patients. (Diagnostic Interview for Genetic Studies, including Schedules for the Assessment of Negative and Positive Symptoms.) Blood samples (karyotyping and/or FISH analysis) as well as urine samples (drug screening) were obtained and nine head and facial measurements were performed. Descriptive statistics were compiled with reference to demographic, clinical and morphological variables. Comparisons between mean differences for these variables were made. Doctoral 2008-11-10T13:27:33Z 2010-06-01T08:14:36Z 2008-11-10T13:27:33Z 2010-06-01T08:14:36Z 2008-12 Thesis http://hdl.handle.net/10019.1/1189 en Stellenbosch University application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | Schizophrenia -- Genetic aspects Morphology Chromosome 22 Xhosa schizophrenia patients Chromosomal aberrations Xhosa (African people) -- Mental health Human chromosome abnormalities Dissertations -- Psychiatry Theses -- Psychiatry Koen, Liezl Chromosomal aberrations in the Xhosa schizophrenia population |
| title | Chromosomal aberrations in the Xhosa schizophrenia population |
| title_full | Chromosomal aberrations in the Xhosa schizophrenia population |
| title_fullStr | Chromosomal aberrations in the Xhosa schizophrenia population |
| title_full_unstemmed | Chromosomal aberrations in the Xhosa schizophrenia population |
| title_short | Chromosomal aberrations in the Xhosa schizophrenia population |
| title_sort | chromosomal aberrations in the xhosa schizophrenia population |
| topic | Schizophrenia -- Genetic aspects Morphology Chromosome 22 Xhosa schizophrenia patients Chromosomal aberrations Xhosa (African people) -- Mental health Human chromosome abnormalities Dissertations -- Psychiatry Theses -- Psychiatry |
| url | http://hdl.handle.net/10019.1/1189 |
| work_keys_str_mv | AT koenliezl chromosomalaberrationsinthexhosaschizophreniapopulation |