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The Correlation between hyponatremia and/or deranged cerebrospinal fluid glucose levels and the severity of childhood tuberculous meningitis
Thesis (MMed)--Stellenbosch University, 2021.
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| Format: | Thesis |
| Language: | en_ZA |
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Stellenbosch : Stellenbosch University
2021
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| _version_ | 1867613880092459008 |
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| access_status_str | Open Access |
| author | Salih, Rashid |
| author2 | Solomons, Regan |
| author_browse | Salih, Rashid Solomons, Regan |
| author_facet | Solomons, Regan Salih, Rashid |
| author_sort | Salih, Rashid |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description | Thesis (MMed)--Stellenbosch University, 2021. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/123632 |
| institution | Stellenbosch University (South Africa) |
| language | en_ZA |
| last_indexed | 2026-06-10T12:43:10.408Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/123632 The Correlation between hyponatremia and/or deranged cerebrospinal fluid glucose levels and the severity of childhood tuberculous meningitis Salih, Rashid Solomons, Regan Van Toorn, Ronald Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Paediatrics and Child Health. Hyponatremia Cerebrospinal Fluid Tuberculosis in children Tuberculous Meningitis UCTD Thesis (MMed)--Stellenbosch University, 2021. Introduction: Hyponatremia and/or hypoglycorrhachia are commonly encountered biochemical derangements during the acute stage of childhood tuberculous meningitis (TBM). Few studies have explored the correlation of the abovementioned derangements in relation to the staging of the disease (severity), as well as being biomarkers for vascular ischemic events, hydrocephalus, and seizures. Objective: We aimed to identify the prevalence and the correlation between serum hyponatremia (mild, moderate and severe) and/or hypoglycorrhachia in relation to clinical TBM features such as stage of disease, seizures and stroke. Design: A retrospective hospital based observational cohort study. Results: The prevalence of hyponatremia was 344 out of 481 (71.5%) patients; 169 (49.1%) had mild hyponatremia, 146 (42.4%) moderate hyponatremia and 29 (8.4%) severe hyponatremia. Increasing severity of hyponatremia was associated with stroke (clinical persistent hemi or quadriparesis with or without radiological infarcts), signs of brainstem dysfunction, cranial nerve palsies and non- communicating hydrocephalus (all p<0.05). No association was identified in relation to the age of the child, duration of symptoms or basal meningeal enhancement on baseline CT imaging. The prevalence of hypoglycorrhachia was 72.9% (3 06 out of 420). Children with hypoglycorrhachia were more likely to exhibited longer symptom duration prior to admission (p=0.02); non-communicating hydrocephalus (p=0.05) as well as higher cerebrospinal cell counts and protein levels (both p <0.01). Conclusion: Hyponatremia and/or hypoglycorrhachia occur in more than two-thirds of children with TBM. Increasing severity of hyponatremia is predictive of TBM disease complications such as stroke and non-communicating hydrocephalus. CSF glucose depletion correlates with non- communicating hydrocephalus and increased CSF inflammation. AFRIKAANSE OPSOMMING: Geen opsomming beskikbaar Masters 2021-07-28T06:09:37Z 2021-12-22T14:13:09Z 2021-07-28T06:09:37Z 2021-12-22T14:13:09Z 2021-03 Thesis http://hdl.handle.net/10019.1/123632 en_ZA Stellenbosch University 32 pages application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | Hyponatremia Cerebrospinal Fluid Tuberculosis in children Tuberculous Meningitis UCTD Salih, Rashid The Correlation between hyponatremia and/or deranged cerebrospinal fluid glucose levels and the severity of childhood tuberculous meningitis |
| title | The Correlation between hyponatremia and/or deranged cerebrospinal fluid glucose levels and the severity of childhood tuberculous meningitis |
| title_full | The Correlation between hyponatremia and/or deranged cerebrospinal fluid glucose levels and the severity of childhood tuberculous meningitis |
| title_fullStr | The Correlation between hyponatremia and/or deranged cerebrospinal fluid glucose levels and the severity of childhood tuberculous meningitis |
| title_full_unstemmed | The Correlation between hyponatremia and/or deranged cerebrospinal fluid glucose levels and the severity of childhood tuberculous meningitis |
| title_short | The Correlation between hyponatremia and/or deranged cerebrospinal fluid glucose levels and the severity of childhood tuberculous meningitis |
| title_sort | correlation between hyponatremia and or deranged cerebrospinal fluid glucose levels and the severity of childhood tuberculous meningitis |
| topic | Hyponatremia Cerebrospinal Fluid Tuberculosis in children Tuberculous Meningitis UCTD |
| url | http://hdl.handle.net/10019.1/123632 |
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