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In-hospital outcomes of congenital syphilis
Thesis (MMed)--Stellenbosch University, 2021.
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| Format: | Thesis |
| Language: | en_ZA |
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Stellenbosch : Stellenbosch University
2021
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| _version_ | 1867614036232765440 |
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| access_status_str | Open Access |
| author | Bekker, Carien |
| author2 | Van Wyk, Lizelle |
| author_browse | Bekker, Carien Van Wyk, Lizelle |
| author_facet | Van Wyk, Lizelle Bekker, Carien |
| author_sort | Bekker, Carien |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description | Thesis (MMed)--Stellenbosch University, 2021. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/123649 |
| institution | Stellenbosch University (South Africa) |
| language | en_ZA |
| last_indexed | 2026-06-10T12:45:38.927Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/123649 In-hospital outcomes of congenital syphilis Bekker, Carien Van Wyk, Lizelle Smith, Johan Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Paediatrics and Child Health. Neonatal mortality Morbidity Congenital diseases UCTD Syphilis, Congenital, hereditary, and infantile Thesis (MMed)--Stellenbosch University, 2021. ENGLISH ABSTRACT: Introduction. Congenital syphilis remains a leading cause of neonatal morbidity and mortality. Although treatable, a worldwide penicillin shortage has led to a resurgence of this disease. The current state of congenital syphilis in the Western Cape, South Africa is unknown. We aim to describe the mortality and clinical outcomes of congenital syphilis at a resource restricted academic hospital in Cape Town, South Africa. Methodology. This was a retrospective, descriptive study performed at Tygerberg Hospital, in 2016, of all neonates diagnosed with congenital syphilis. All neonates with a positive rapid plasma reagin (RPR) test, meeting the Centers for Disease Control and Prevention (CDC) criteria for congenital syphilis, admitted to Tygerberg Hospital neonatal service, within the first month of life, were included. Neonates were excluded if clinical data were not available. Results. Seventy neonates were diagnosed with congenital syphilis. The mean gestational age was 34.8±3.7 weeks and mean birth weight was 2247±717g.The most common clinical findings included respiratory distress (54%), bone abnormalities (43%), thrombocytopaenia (32%) and hepatomegaly (30%). Survival was 89%, with mortality significantly associated with septic shock and prematurity. Conclusion. We present a cohort, over one year, of congenital syphilis with an 89% survival rate, despite significant morbidities. Prematurity and septic shock were associated with increased mortality. Despite this, most neonates survived and were transferred to other facilities or discharged within 2 weeks of birth. AFRIKAANSE OPSOMMIMG: Inleiding. Kongenitale sifilis bly een van die algemeenste oorsake van neonatale morbiditeit en mortaliteit. Alhoewel dit behandelbaar is, het die wêreldwye tekort aan penisillien tot ‘n toename in dié siekte gelei. Die huidige stand van kongenitale sifillis in die Weskaap, Suid Afrika, is onbekend. Ons beskryf die mortaliteit en kliniese uitkomste van kongenitale sifilis in ‘n hulpbronbeperkte hospitaal in Kaapstad, Suid Afrika. Metodes. Hierdie was ‘n retrospektiewe, beskrywende studie, uitgevoer te Tygerberg Hospitaal in 2016, van alle neonate wat met kongenitale sifillis gediagnoseer is. Alle neonate met ‘n positiewe RPR toets wat in Tygerberg Hospitaal toegelaat is binne die eerste maand van lewe, is in die studie ingesluit. Neonate is uitgesluit indien mediese data onvoldoende was. Uitslae. Sewentig neonate was toegelaat met kongenitale sifillis, met ‘n gemiddelde gestasie van 34.8±3.7 weke en ‘n gemiddelde geboortegewig van 2247±717g. Die algemeenste kliniese bevindinge was asemhalingsnood (54%), benige abnormaliteite (43%), lae plaatjietelling (32%) and hepatomegalie (30%). Die oorlewing was 89%, en sterfte was geassosieer met prematuriteit en septiese skok. Opsomming. Ons beskryf ‘n groep neonate wat oor ‘n tydperk van een jaar met kongenitale sifillis gediagnoseer is, met ‘n oorlewing van 89% ondanks ‘n hoë voorkoms van morbiditeit. Bevindinge wat met sterfte verband gehou het, was prematuriteit en septiese skok. Ten spyte hiervan was die meeste neonate binne die eerste 2 weke van lewe na ander fasiliteite oorgeplaas of huis toe ontslaan. Masters 2021-08-27T10:17:32Z 2021-12-22T14:13:59Z 2021-08-27T10:17:32Z 2021-12-22T14:13:59Z 2021-12 Thesis http://hdl.handle.net/10019.1/123649 en_ZA Stellenbosch University 42 pages application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | Neonatal mortality Morbidity Congenital diseases UCTD Syphilis, Congenital, hereditary, and infantile Bekker, Carien In-hospital outcomes of congenital syphilis |
| title | In-hospital outcomes of congenital syphilis |
| title_full | In-hospital outcomes of congenital syphilis |
| title_fullStr | In-hospital outcomes of congenital syphilis |
| title_full_unstemmed | In-hospital outcomes of congenital syphilis |
| title_short | In-hospital outcomes of congenital syphilis |
| title_sort | in hospital outcomes of congenital syphilis |
| topic | Neonatal mortality Morbidity Congenital diseases UCTD Syphilis, Congenital, hereditary, and infantile |
| url | http://hdl.handle.net/10019.1/123649 |
| work_keys_str_mv | AT bekkercarien inhospitaloutcomesofcongenitalsyphilis |