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The Tygerberg Endocarditis Cohort (TEC) Study
Thesis (PhD)--Stellenbosch University, 2021
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| Format: | Thesis |
| Language: | en_ZA |
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Stellenbosch : Stellenbosch University, 2021
2021
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| _version_ | 1867613900526059520 |
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| access_status_str | Open Access |
| author | Pecoraro, Alfonso Jan Kemp |
| author2 | Doubell, Anton Frans |
| author_browse | Doubell, Anton Frans Pecoraro, Alfonso Jan Kemp |
| author_facet | Doubell, Anton Frans Pecoraro, Alfonso Jan Kemp |
| author_sort | Pecoraro, Alfonso Jan Kemp |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description | Thesis (PhD)--Stellenbosch University, 2021 |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/124218 |
| institution | Stellenbosch University (South Africa) |
| language | en_ZA |
| last_indexed | 2026-06-10T12:43:29.841Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Stellenbosch : Stellenbosch University, 2021 |
| publisherStr | Stellenbosch : Stellenbosch University, 2021 |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/124218 The Tygerberg Endocarditis Cohort (TEC) Study Pecoraro, Alfonso Jan Kemp Doubell, Anton Frans Herbst, Philippus George Janson, Jacques Teran Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Medicine: Cardiology. Infective endocarditis Rheumatic heart disease Heart valves -- Surgery Culturing organisms Cardiology Bartonella species Blood culture Heart disease -- Diagnosis UCTD Thesis (PhD)--Stellenbosch University, 2021 ENGLISH ABSTRACT: Background: The diagnosis of infective endocarditis (IE) is based on the modified Duke/ESC 2015 clinical criteria. The sensitivity of the criteria is unknown in South Africa, but high rates of blood culture negative endocarditis (BCNIE), coupled with a change in the clinical features of IE, may limit the sensitivity. Methods: The Tygerberg Endocarditis Cohort (TEC) study prospectively enrolled patients with IE between November 2019 and June 2021. A standardised protocol for organism detection, with management of patients by an Endocarditis Team, was employed. Patients with definite IE by pathological criteria were analysed to determine the sensitivity of the current clinical criteria. Results: Eighty (80) consecutive patients with IE were included of which 45 (56.3%) had definite IE by pathological criteria. In patients with definite IE by pathological criteria, 26/45 (57.8%) of patients were classified as definite IE by clinical criteria. BCNIE was present in 25/45 (55.6%) of patients and less than three minor clinical criteria were present in 32/45 (75.6%) of patients. The elevation of Bartonella serology to a major microbiological criterion of the modified Duke/ESC 2015 clinical criteria would increase the sensitivity (56.3% vs. 77.8%; p=0.07). Conclusion: The sensitivity of the modified Duke/ESC 2015 clinical criteria is lower than expected in patients with IE in South Africa, primarily due to the high rates of Bartonella-associated BCNIE. The elevation of Bartonella serology to a major microbiological criterion, similar to the status of Coxiella burnetii in the current criteria, would increase the sensitivity. The majority of patients with definite IE by pathological criteria had less than three minor criteria present. AFRIKAANSE OPSOMMING: Geen opsomming beskikbaar. Doctoral 2021-10-21T13:02:22Z 2022-02-22T10:17:06Z 2021-10-21T13:02:22Z 2021-12 Thesis http://hdl.handle.net/10019.1/124218 en_ZA Stellenbosch University 109 pages : illustrations application/pdf Stellenbosch : Stellenbosch University, 2021 |
| spellingShingle | Infective endocarditis Rheumatic heart disease Heart valves -- Surgery Culturing organisms Cardiology Bartonella species Blood culture Heart disease -- Diagnosis UCTD Pecoraro, Alfonso Jan Kemp The Tygerberg Endocarditis Cohort (TEC) Study |
| title | The Tygerberg Endocarditis Cohort (TEC) Study |
| title_full | The Tygerberg Endocarditis Cohort (TEC) Study |
| title_fullStr | The Tygerberg Endocarditis Cohort (TEC) Study |
| title_full_unstemmed | The Tygerberg Endocarditis Cohort (TEC) Study |
| title_short | The Tygerberg Endocarditis Cohort (TEC) Study |
| title_sort | tygerberg endocarditis cohort tec study |
| topic | Infective endocarditis Rheumatic heart disease Heart valves -- Surgery Culturing organisms Cardiology Bartonella species Blood culture Heart disease -- Diagnosis UCTD |
| url | http://hdl.handle.net/10019.1/124218 |
| work_keys_str_mv | AT pecoraroalfonsojankemp thetygerbergendocarditiscohorttecstudy AT pecoraroalfonsojankemp tygerbergendocarditiscohorttecstudy |