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Effect of pharmacological modulation of myeloid-derived suppressor cell function on immune reactivity against mycobacterium tuberculosis.
Thesis (PhD)--Stellenbosch University, 2023.
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| Format: | Thesis |
| Language: | en_ZA |
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Stellenbosch : Stellenbosch University
2022
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| _version_ | 1867613975505534976 |
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| access_status_str | Open Access |
| author | Leukes, Vinzeigh |
| author2 | Du Plessis, Nelita |
| author_browse | Du Plessis, Nelita Leukes, Vinzeigh |
| author_facet | Du Plessis, Nelita Leukes, Vinzeigh |
| author_sort | Leukes, Vinzeigh |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description | Thesis (PhD)--Stellenbosch University, 2023. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/125155 |
| institution | Stellenbosch University (South Africa) |
| language | en_ZA |
| last_indexed | 2026-06-10T12:44:41.084Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/125155 Effect of pharmacological modulation of myeloid-derived suppressor cell function on immune reactivity against mycobacterium tuberculosis. Leukes, Vinzeigh Du Plessis, Nelita Walzl, Gerhard Dorhoi, Anca Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Biomedical Sciences. Molecular Biology and Human Genetics. Multidrug resistance Mycobacterium tuberculosis -- Alternative treatment Mycobacterial diseases Suppressor cells Thesis (PhD)--Stellenbosch University, 2023. ENGLISH ABSTRACT: Mycobacterium tuberculosis (M.tb) is likely the most successful human pathogen, capable of evading protective host immune responses and driving metabolic changes to support its own survival and growth. Ineffective innate and adaptive immune responses inhibit effective clearance of the bacteria from the human host, resulting in the progression to active TB disease. Many regulatory mechanisms exist to prevent immunopathology, however, chronic infections result in the overproduction of regulatory myeloid cells, like myeloid-derived suppressor cells (MDSC), which actively suppress protective host T lymphocyte responses among other immunosuppressive mechanisms. The mechanisms of M.tb internalization by MDSC and the involvement of host-derived lipid acquisition, have not been fully elucidated. Targeted research aimed at investigating MDSC impact on phagocytic control of M.tb, would be advantageous to our collective anti-TB arsenal. In this review we propose a mechanism by which M.tb may be internalized by MDSC and survive via the manipulation of host-derived lipid sources. AFRIKAANSE OPSOMMING: Geen opsomming beskikbaar. Doctorate 2022-01-10T10:58:23Z 2022-04-29T12:56:24Z 2022-01-10T10:58:23Z 2022-04-29T12:56:24Z 2021-12 Thesis http://hdl.handle.net/10019.1/125155 en_ZA Stellenbosch University 258 pages : illustrations application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | Multidrug resistance Mycobacterium tuberculosis -- Alternative treatment Mycobacterial diseases Suppressor cells Leukes, Vinzeigh Effect of pharmacological modulation of myeloid-derived suppressor cell function on immune reactivity against mycobacterium tuberculosis. |
| title | Effect of pharmacological modulation of myeloid-derived suppressor cell function on immune reactivity against mycobacterium tuberculosis. |
| title_full | Effect of pharmacological modulation of myeloid-derived suppressor cell function on immune reactivity against mycobacterium tuberculosis. |
| title_fullStr | Effect of pharmacological modulation of myeloid-derived suppressor cell function on immune reactivity against mycobacterium tuberculosis. |
| title_full_unstemmed | Effect of pharmacological modulation of myeloid-derived suppressor cell function on immune reactivity against mycobacterium tuberculosis. |
| title_short | Effect of pharmacological modulation of myeloid-derived suppressor cell function on immune reactivity against mycobacterium tuberculosis. |
| title_sort | effect of pharmacological modulation of myeloid derived suppressor cell function on immune reactivity against mycobacterium tuberculosis |
| topic | Multidrug resistance Mycobacterium tuberculosis -- Alternative treatment Mycobacterial diseases Suppressor cells |
| url | http://hdl.handle.net/10019.1/125155 |
| work_keys_str_mv | AT leukesvinzeigh effectofpharmacologicalmodulationofmyeloidderivedsuppressorcellfunctiononimmunereactivityagainstmycobacteriumtuberculosis |