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Outcomes of children with malignant extracranial germ cell tumours at Tygerberg hospital
Thesis (MMed)--Stellenbosch University, 2023.
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| Format: | Thesis |
| Language: | en_ZA |
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Stellenbosch : Stellenbosch University
2023
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| _version_ | 1867613879200120832 |
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| access_status_str | Open Access |
| author | Louw, Byron |
| author2 | Kruger, M., (Mariana) |
| author_browse | Kruger, M., (Mariana) Louw, Byron |
| author_facet | Kruger, M., (Mariana) Louw, Byron |
| author_sort | Louw, Byron |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description | Thesis (MMed)--Stellenbosch University, 2023. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/127109 |
| institution | Stellenbosch University (South Africa) |
| language | en_ZA |
| last_indexed | 2026-06-10T12:43:09.148Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/127109 Outcomes of children with malignant extracranial germ cell tumours at Tygerberg hospital Louw, Byron Kruger, M., (Mariana) Van Zyl, Anel Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Paediatrics and Child Health. Tumors in children -- Western Cape (South Africa) Germ cells -- Tumors -- Western Cape (South Africa) Germ cells -- Western Cape (South Africa) UCTD Thesis (MMed)--Stellenbosch University, 2023. ENGLISH SUMMARY: INTRODUCTION: The objective of this study was to document the outcome of patients with malignant extracranial germ cell tumours (MEGCTs) at a paediatric oncology unit in Cape Town in the Western Cape province of South Africa. METHODS: All children diagnosed with an MEGCT between 2003 and 2018 at Tygerberg Hospital were included in the study. Data collected included demographic data, histology, tumour site, and stage, alpha-fetoprotein (AFP) level at diagnosis, treatment modalities and outcome. The data were analysed with Stata version 16.1 following a three-step analytical approach for descriptive statistics and correlational and survival analysis. RESULTS: Seventeen children were included; none were excluded. The median age was 18 months with a mean of 53.9 months (interquartile range (IQR) 8-102; standard deviation (SD) 53.8). The male-to-female ratio was 1:2.4. Seven children (41.2%) had ovarian tumours (granulosa cell tumour n=2; immature teratoma n=2; mixed germ cell tumour n=2; germinoma n=1), and four had testicular tumours (yolk sac tumour n=3; granulosa cell tumour n=1). Five patients had a sacrococcygeal yolk sac tumour and one had a pelvic immature teratoma. Nine children had only surgery, while the other eight had chemotherapy in addition to surgery. The event-free survival rate was 88.2%. One child with relapsed disease survived after successful treatment with second-line chemotherapy. Only one child, with metastatic sacrococcygeal yolk sac tumour, died. This small cohort's overall survival (OS) was excellent, with 94.1% (95% CI 71.3 - 99.9%) surviving. CONCLUSION: The outcome of this small cohort of children with MEGCT treated at Tygerberg Hospital was excellent. The one child who died had metastatic disease, supporting the importance of early diagnosis of this rare childhood cancer. AFRIKAANSE OPSOMMING: Geen opsomming beskikbaar. Masters 2023-03-04T14:04:14Z 2023-05-18T07:04:42Z 2023-03-04T14:04:14Z 2023-05-18T07:04:42Z 2023-03 Thesis http://hdl.handle.net/10019.1/127109 en_ZA Stellenbosch University ii, 35 pages ; includes annexures application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | Tumors in children -- Western Cape (South Africa) Germ cells -- Tumors -- Western Cape (South Africa) Germ cells -- Western Cape (South Africa) UCTD Louw, Byron Outcomes of children with malignant extracranial germ cell tumours at Tygerberg hospital |
| title | Outcomes of children with malignant extracranial germ cell tumours at Tygerberg hospital |
| title_full | Outcomes of children with malignant extracranial germ cell tumours at Tygerberg hospital |
| title_fullStr | Outcomes of children with malignant extracranial germ cell tumours at Tygerberg hospital |
| title_full_unstemmed | Outcomes of children with malignant extracranial germ cell tumours at Tygerberg hospital |
| title_short | Outcomes of children with malignant extracranial germ cell tumours at Tygerberg hospital |
| title_sort | outcomes of children with malignant extracranial germ cell tumours at tygerberg hospital |
| topic | Tumors in children -- Western Cape (South Africa) Germ cells -- Tumors -- Western Cape (South Africa) Germ cells -- Western Cape (South Africa) UCTD |
| url | http://hdl.handle.net/10019.1/127109 |
| work_keys_str_mv | AT louwbyron outcomesofchildrenwithmalignantextracranialgermcelltumoursattygerberghospital |