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Short-term outcomes of children with multisystem inflammatory syndrome in children (MIS-C) in South Africa : a prospective cohort study
Thesis (MPhil)--Stellenbosch University, 2023.
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| Format: | Thesis |
| Language: | en_ZA |
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Stellenbosch : Stellenbosch University
2023
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| _version_ | 1867613758690426880 |
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| access_status_str | Open Access |
| author | Lishman, Juanita |
| author2 | Rabie, Helena |
| author_browse | Lishman, Juanita Rabie, Helena |
| author_facet | Rabie, Helena Lishman, Juanita |
| author_sort | Lishman, Juanita |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description | Thesis (MPhil)--Stellenbosch University, 2023. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/127222 |
| institution | Stellenbosch University (South Africa) |
| language | en_ZA |
| last_indexed | 2026-06-10T12:41:14.564Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/127222 Short-term outcomes of children with multisystem inflammatory syndrome in children (MIS-C) in South Africa : a prospective cohort study Lishman, Juanita Rabie, Helena Abraham, Deepthi Raju Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Paediatrics and Child Health. Sick children -- Health and hygiene -- South Africa Inflammation -- Children -- South Africa Coronavirus infections -- Children -- South Africa SARS (Disease) -- Children -- South Africa UCTD Thesis (MPhil)--Stellenbosch University, 2023. ENGLISH SUMMARY: Background: Despite the life-threatening presentation of MISC in children, the overall prognosis is favourable in centers with access to appropriate supportive care. In this study we investigate the short-term outcomes in children with MIS-C in Cape Town, South Africa. Methods: This prospective observational cohort study in children <13 years who fulfilled the World Health Organization (WHO) case definition of MIS-C and were admitted to Tygerberg Hospital in Cape Town between 1 June 2020 and 31 October 2021. Clinical features were recorded at baseline and at followup at cardiology and rheumatology-immunology clinics respectively. Findings: Fifty-three children with a median age of 7.4 years (interquartile range (IQR) 4.2-9.9) MIS-C were included. There was a slight male predominance (30/53; 56,6%) and the majority was of mixed-race (28/53; 52,83%) or black African ancestry (24/53; 45,3%). Fourteen children (14/53; 26,4%) had comorbid disease. The median length of hospital stay was 8 days (IQR 6-10). All children had an echocardiogram performed at baseline of which 39 were abnormal (39/53; 73,6%). The majority had elevated markers of inflammation, lymphopenia, anaemia, renal impairment, hyponatremia, and elevated cardiac enzymes during the acute phase. All children were discharged alive. The median days from discharge to cardiology follow-up was 39 days (IQR 33.5-41.5) and for rheumatology immunology clinic was 70.5 days (IQR 59.5-85.0). Eleven children (11/41; 26,8%) had a persistently abnormal echocardiogram at cardiology follow-up. Systemic inflammation and organ dysfunction resolved in most. Interpretation: Although the short-term outcomes of MIS-C in our cohort were generally good, the cardiac morbidity needs further characterization and follow-up. AFRIKAANSE OPSOMMING: Geen opsomming beskikbaar. Masters 2023-03-04T14:16:32Z 2023-05-18T07:10:34Z 2023-03-04T14:16:32Z 2023-05-18T07:10:34Z 2023-03 Thesis http://hdl.handle.net/10019.1/127222 en_ZA Stellenbosch University 55 pages ; includes annexures application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | Sick children -- Health and hygiene -- South Africa Inflammation -- Children -- South Africa Coronavirus infections -- Children -- South Africa SARS (Disease) -- Children -- South Africa UCTD Lishman, Juanita Short-term outcomes of children with multisystem inflammatory syndrome in children (MIS-C) in South Africa : a prospective cohort study |
| title | Short-term outcomes of children with multisystem inflammatory syndrome in children (MIS-C) in South Africa : a prospective cohort study |
| title_full | Short-term outcomes of children with multisystem inflammatory syndrome in children (MIS-C) in South Africa : a prospective cohort study |
| title_fullStr | Short-term outcomes of children with multisystem inflammatory syndrome in children (MIS-C) in South Africa : a prospective cohort study |
| title_full_unstemmed | Short-term outcomes of children with multisystem inflammatory syndrome in children (MIS-C) in South Africa : a prospective cohort study |
| title_short | Short-term outcomes of children with multisystem inflammatory syndrome in children (MIS-C) in South Africa : a prospective cohort study |
| title_sort | short term outcomes of children with multisystem inflammatory syndrome in children mis c in south africa a prospective cohort study |
| topic | Sick children -- Health and hygiene -- South Africa Inflammation -- Children -- South Africa Coronavirus infections -- Children -- South Africa SARS (Disease) -- Children -- South Africa UCTD |
| url | http://hdl.handle.net/10019.1/127222 |
| work_keys_str_mv | AT lishmanjuanita shorttermoutcomesofchildrenwithmultisysteminflammatorysyndromeinchildrenmiscinsouthafricaaprospectivecohortstudy |