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Placental syphilis: a comprehensive review of routine histomorphology, HIV co-infection, penicillin treatment, immunohistochemistry, and polymerase chain reaction.
Thesis (MMed)--Stellenbosch University, 2023.
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| Format: | Thesis |
| Language: | en_ZA en_ZA |
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Stellenbosch : Stellenbosch University
2023
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| _version_ | 1867613743833153536 |
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| access_status_str | Open Access |
| author | Marais, Yolandi Anne |
| author2 | Schubert, Pawel Tomasz |
| author_browse | Marais, Yolandi Anne Schubert, Pawel Tomasz |
| author_facet | Schubert, Pawel Tomasz Marais, Yolandi Anne |
| author_sort | Marais, Yolandi Anne |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University. |
| description | Thesis (MMed)--Stellenbosch University, 2023. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/128936 |
| institution | Stellenbosch University (South Africa) |
| language | en_ZA en_ZA |
| last_indexed | 2026-06-10T12:41:00.180Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/128936 Placental syphilis: a comprehensive review of routine histomorphology, HIV co-infection, penicillin treatment, immunohistochemistry, and polymerase chain reaction. Marais, Yolandi Anne Schubert, Pawel Tomasz Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Pathology. Division of Anatomical Pathology. Syphilis, Congenital, hereditary, and infantile Treponema pallidum Immunohistochemistry Treponema pallidum Syphilis -- Diagnosis Thesis (MMed)--Stellenbosch University, 2023. ENGLISH ABSTRACT: Introduction: Placental examination is useful to diagnose congenital syphilis. The classical histological diagnostic triad is, however, an infrequent finding. Additional morphological clues, special investigations, and knowledge of potential alterations by HIV co-infection and penicillin treatment can aid in making the diagnosis. Materials and methods: Placental specimens diagnosed with treponemal infection were reviewed. Morphological findings, IHC and qPCR results were assessed. Results: Two-hundred and twenty-two placentas were recruited. Villitis (93.2%), acute chorioamnionitis (91%) and villous immaturity (64%) were the most common abnormalities. HIV co-infection and penicillin treatment demonstrated alterations that may hamper diagnosis. Treponema IHC and q-PCR had a sensitivity of 74.4% and 25.81%, respectively and confirmed an additional 41 cases with negative or unknown serology. Conclusion: Villitis, acute chorioamnionitis and villous immaturity are the most common microscopic abnormalities in placental syphilis. HIV co-infection and penicillin treatment may alter morphology. Treponema IHC and q-PCR are useful adjuncts when serology is negative. AFRIKAANSE OPSOMMING: Geen opsomming beskikbaar. Masters 2023-11-22T10:28:46Z 2024-01-08T16:26:10Z 2023-11-22T10:28:46Z 2024-01-08T16:26:10Z 2023-04 Thesis https://scholar.sun.ac.za/handle/10019.1/128936 en_ZA en_ZA Stellenbosch University. 42 pages application/pdf application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | Syphilis, Congenital, hereditary, and infantile Treponema pallidum Immunohistochemistry Treponema pallidum Syphilis -- Diagnosis Marais, Yolandi Anne Placental syphilis: a comprehensive review of routine histomorphology, HIV co-infection, penicillin treatment, immunohistochemistry, and polymerase chain reaction. |
| title | Placental syphilis: a comprehensive review of routine histomorphology, HIV co-infection, penicillin treatment, immunohistochemistry, and polymerase chain reaction. |
| title_full | Placental syphilis: a comprehensive review of routine histomorphology, HIV co-infection, penicillin treatment, immunohistochemistry, and polymerase chain reaction. |
| title_fullStr | Placental syphilis: a comprehensive review of routine histomorphology, HIV co-infection, penicillin treatment, immunohistochemistry, and polymerase chain reaction. |
| title_full_unstemmed | Placental syphilis: a comprehensive review of routine histomorphology, HIV co-infection, penicillin treatment, immunohistochemistry, and polymerase chain reaction. |
| title_short | Placental syphilis: a comprehensive review of routine histomorphology, HIV co-infection, penicillin treatment, immunohistochemistry, and polymerase chain reaction. |
| title_sort | placental syphilis a comprehensive review of routine histomorphology hiv co infection penicillin treatment immunohistochemistry and polymerase chain reaction |
| topic | Syphilis, Congenital, hereditary, and infantile Treponema pallidum Immunohistochemistry Treponema pallidum Syphilis -- Diagnosis |
| url | https://scholar.sun.ac.za/handle/10019.1/128936 |
| work_keys_str_mv | AT maraisyolandianne placentalsyphilisacomprehensivereviewofroutinehistomorphologyhivcoinfectionpenicillintreatmentimmunohistochemistryandpolymerasechainreaction |