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Prevalence of ERG overexpression in prostate cancer on prostate biopsies at a tertiary public hospital in the Western Cape, South Africa
Thesis (MMed)--Stellenbosch University, 2023.
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| Format: | Thesis |
| Language: | en_ZA en_ZA |
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Stellenbosch : Stellenbosch University
2023
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| _version_ | 1867613875803783168 |
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| access_status_str | Open Access |
| author | McCree, Kevin |
| author2 | Van Wyk, Abrie |
| author_browse | McCree, Kevin Van Wyk, Abrie |
| author_facet | Van Wyk, Abrie McCree, Kevin |
| author_sort | McCree, Kevin |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description | Thesis (MMed)--Stellenbosch University, 2023. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/130561 |
| institution | Stellenbosch University (South Africa) |
| language | en_ZA en_ZA |
| last_indexed | 2026-06-10T12:43:06.129Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/130561 Prevalence of ERG overexpression in prostate cancer on prostate biopsies at a tertiary public hospital in the Western Cape, South Africa McCree, Kevin Van Wyk, Abrie Fernandez, Pedro Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Pathology. Division of Anatomical Pathology. Prostate -- Cancer Adenocarcinoma Overexpression (Genetics) TMPRSS2-ERG fusion Thesis (MMed)--Stellenbosch University, 2023. ENGLISH ABSTRACT: Background: Prostate cancer is the most diagnosed non-cutaneous malignancy in men in South Africa across all race groups with 10495 new cases reported in 2019. The TMPRSS2-ERG fusion gene and resultant overexpression of ERG is estimated to occur at a rate of 30-50% within prostate cancer. The fusion gene is specific to prostate cancer and high grade prostatic intraepithelial neoplasia and has not been reported in other malignant neoplasms. The TMPRSS2-ERG fusion gene, and by implication the overexpression of ERG, may serve as a diagnostic, prognostic or therapeutic biomarker. The prevalence of the TMPRSS2-ERG fusion gene in prostate carcinoma in South Africa has not been investigated previously. We sought to determine the prevalence of the TMPRSS2-ERG gene fusion among men undergoing prostate biopsies at Tygerberg Hospital, Cape Town, South Africa and to determine whether there is an association between prostate cancer grade and ethnicity/race. Methods: This is a retrospective descriptive laboratory study where we analysed 362 prostate biopsies, diagnosed with prostate cancer, between January 2010 and December 2017. All 362 cases were reviewed, and the diagnosis was confirmed. 336 cases were stained with ERG (Cell Marque, clone EP111) an adequate surrogate marker for the TMPRSS2-ERG fusion gene. The prevalence was calculated and compared with Gleason grade group and ethnicity/race to determine if there is an association. Results: ERG overexpression was detected in 34% of cases. Our study showed an association with a lower Gleason score and ERG overexpression. There is a higher prevalence of TMPRSS2-ERG amongst the coloured population in this cohort, at 34%. Conclusions: This is the first study to characterise the prevalence of ERG overexpression in prostate cancer in patients who underwent prostate biopsies in South Africa. Our results show that this gene rearrangement is common in the study population and that the prevalence of 34% is within the range reported in international literature. AFRIKAANSE OPSOMMING: Geen opsomming beskikbaar. Masters 2023-11-23T07:33:57Z 2024-04-26T22:05:39Z 2023-11-23T07:33:57Z 2024-04-26T22:05:39Z 2023-12 Thesis https://scholar.sun.ac.za/handle/10019.1/130561 en_ZA en_ZA Stellenbosch University 13 pages application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | Prostate -- Cancer Adenocarcinoma Overexpression (Genetics) TMPRSS2-ERG fusion McCree, Kevin Prevalence of ERG overexpression in prostate cancer on prostate biopsies at a tertiary public hospital in the Western Cape, South Africa |
| title | Prevalence of ERG overexpression in prostate cancer on prostate biopsies at a tertiary public hospital in the Western Cape, South Africa |
| title_full | Prevalence of ERG overexpression in prostate cancer on prostate biopsies at a tertiary public hospital in the Western Cape, South Africa |
| title_fullStr | Prevalence of ERG overexpression in prostate cancer on prostate biopsies at a tertiary public hospital in the Western Cape, South Africa |
| title_full_unstemmed | Prevalence of ERG overexpression in prostate cancer on prostate biopsies at a tertiary public hospital in the Western Cape, South Africa |
| title_short | Prevalence of ERG overexpression in prostate cancer on prostate biopsies at a tertiary public hospital in the Western Cape, South Africa |
| title_sort | prevalence of erg overexpression in prostate cancer on prostate biopsies at a tertiary public hospital in the western cape south africa |
| topic | Prostate -- Cancer Adenocarcinoma Overexpression (Genetics) TMPRSS2-ERG fusion |
| url | https://scholar.sun.ac.za/handle/10019.1/130561 |
| work_keys_str_mv | AT mccreekevin prevalenceofergoverexpressioninprostatecanceronprostatebiopsiesatatertiarypublichospitalinthewesterncapesouthafrica |