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The role of a multi-strain probiotic in very low birth weight premature infants
Thesis (PhD)--Stellenbosch University, 2024.
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| Format: | Thesis |
| Language: | en_ZA |
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Stellenbosch : Stellenbosch University
2024
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| _version_ | 1867614094155055104 |
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| access_status_str | Open Access |
| author | Sowden, Marwyn |
| author2 | Van Niekerk, Evette |
| author_browse | Sowden, Marwyn Van Niekerk, Evette |
| author_facet | Van Niekerk, Evette Sowden, Marwyn |
| author_sort | Sowden, Marwyn |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description | Thesis (PhD)--Stellenbosch University, 2024. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/130599 |
| institution | Stellenbosch University (South Africa) |
| language | en_ZA |
| last_indexed | 2026-06-10T12:46:33.531Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/130599 The role of a multi-strain probiotic in very low birth weight premature infants Sowden, Marwyn Van Niekerk, Evette Van Weissenbruch, Mirjam Bulabula, Andy Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Global Health. Human Nutrition. Gastrointestinal system -- Diseases Intestines -- Microbiology Premature infants -- Development Neonatal intensive care UCTD Thesis (PhD)--Stellenbosch University, 2024. ENGLISH SUMMARY: Background: Researchers have established that the preterm neonate is born with an immature gastrointestinal tract. The preterm neonate is thus susceptible to various complications often seen in the neonatal intensive care unit, e.g. feeding intolerances, necrotising enterocolitis, and hospital-acquired bloodstream infections. These complications can be life-threatening, and if survived, can have an unfavorable effect on the neonate’s growth and development. Aim: The aims of this narrative review article were to provide an in-depth understanding of the various factors contributing to the development of the preterm neonatal microbiome. Further, we reviewed gastrointestinal microbiome dysbiosis and its potential role in the development of feeding intolerances, necotising enterocolitis, and hospital-acquired bloodstream infections. Lastly, we described the potential role of probiotics in this vulnerable population. Methods: A PubMed database search was conducted identifying articles that describe the development and function of the neonatal microbiome, the role of gastrointestinal dysbiosis, and the development of neonatal complications as well as the role of probiotics in gastrointestinal dysbiosis. Results: Various maternal, neonatal, and environmental factors play a role in the development of gastrointestinal dysbiosis in the preterm neonate. This can lead to feeding intolerances, necrotising enterocolitis, and hospital-acquired bloodstream infections. Discussion: The pathogenesis of the development of short-term complications in the preterm neonate can be linked to the immaturity of the host immune system as well as alterations seen in the intestinal microbiome. There is a growing body of evidence that probiotics can play a role in preventing dysbiosis and thus complications observed in the preterm neonate. However, the optimal combination of probiotic strains and dosage still needs to be identified. AFRIKAANSE OPSOMMING: Geen opsomming beskikbaar. Doctorate 2024-01-15T09:27:26Z 2024-04-26T23:28:40Z 2024-01-15T09:27:26Z 2024-04-26T23:28:40Z 2024-03 Thesis https://scholar.sun.ac.za/handle/10019.1/130599 en_ZA Stellenbosch University 144 pages : illustrations, includes annexures application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | Gastrointestinal system -- Diseases Intestines -- Microbiology Premature infants -- Development Neonatal intensive care UCTD Sowden, Marwyn The role of a multi-strain probiotic in very low birth weight premature infants |
| title | The role of a multi-strain probiotic in very low birth weight premature infants
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| title_full | The role of a multi-strain probiotic in very low birth weight premature infants
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| title_fullStr | The role of a multi-strain probiotic in very low birth weight premature infants
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| title_full_unstemmed | The role of a multi-strain probiotic in very low birth weight premature infants
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| title_short | The role of a multi-strain probiotic in very low birth weight premature infants
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| title_sort | role of a multi strain probiotic in very low birth weight premature infants |
| topic | Gastrointestinal system -- Diseases Intestines -- Microbiology Premature infants -- Development Neonatal intensive care UCTD |
| url | https://scholar.sun.ac.za/handle/10019.1/130599 |
| work_keys_str_mv | AT sowdenmarwyn theroleofamultistrainprobioticinverylowbirthweightprematureinfants AT sowdenmarwyn roleofamultistrainprobioticinverylowbirthweightprematureinfants |