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A framework for evaluating the TCO of vaccine carrier technology.
Thesis (MEng)--Stellenbosch University, 2023.
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| Format: | Thesis |
| Language: | en_ZA en_ZA |
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Stellenbosch : Stellenbosch University
2024
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| _version_ | 1867613800014807040 |
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| access_status_str | Open Access |
| author | Manuel, Joel Wade |
| author2 | Grobbelaar, S. S. |
| author_browse | Grobbelaar, S. S. Manuel, Joel Wade |
| author_facet | Grobbelaar, S. S. Manuel, Joel Wade |
| author_sort | Manuel, Joel Wade |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description | Thesis (MEng)--Stellenbosch University, 2023. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/130686 |
| institution | Stellenbosch University (South Africa) |
| language | en_ZA en_ZA |
| last_indexed | 2026-06-10T12:41:53.663Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/130686 A framework for evaluating the TCO of vaccine carrier technology. Manuel, Joel Wade Grobbelaar, S. S. Louw, Louis Stellenbosch University. Faculty of Engineering. Dept. of Industrial Engineering. Vaccines industry -- Technological innovations Medical technology Life cycle costing UCTD Thesis (MEng)--Stellenbosch University, 2023. ENGLISH ABSTRACT: The increasing use of vaccines necessitates the identification of new target groups and the expansion of immunisation activities. However, this expansion often challenges areas with inadequate infrastructure and cold chain networks to support vaccine carrier technology throughout its life cycle. Moreover, healthcare providers encounter difficulties in adopting vaccine technology due to insufficient understanding of the associated life cycle costs. Similarly, medical distributors face challenges in adopting these technologies due to insufficient awareness of the total cost implications associated with each vaccine carrier through its entire life cycle. To address these concerns, Total Cost of Ownership (TCO) has been identified as a tool to assist healthcare providers in understanding the feasibility of vaccine technology adoption through its life cycle. This research aims to develop a robust conceptual framework and toolkit for evaluating the TCO of vaccine carrier technologies. To achieve this, the study outlines seven specific objectives that were translated into research design based on the six Design Science Research Methodology (DSRM) activities. The initial phase involved problem identification, entailing a clear definition of the problem, establishment of objectives and an extensive literature review. This literature review delved into existing models and frameworks, analysed key methodologies, and considered relevant definitions, concepts, principles, and parameters to form the foundation for further research development. Subsequently, a Preliminary TCO Framework was shaped, outlining the design process, and identifying key concepts, principles, and cost categories, by utilising existing literature-based TCO methods. Specific design requirements were then established during the preliminary phase to set criteria for thorough calibration of a Preliminary TCO Framework and toolkit. The research incorporated semi-structured interviews with industry experts to validate and enhance the Preliminary TCO Framework. The aim was to ensure the alignment of concepts, principles, and methodologies with real-world applications, facilitating a qualitative analysis. Following the Design Science Research Methodology (DSRM), the refined framework underwent a comprehensive review and integration of qualitative outputs. A toolkit designed for evaluating TCO through case study analysis was outlined within the study. Case study research was then employed to evaluate the refined TCO Framework and toolkit, with explicit criteria outlined by DSRM. The contribution of this research lies in the integration of Design Science Research, resulting in an enhanced framework for the iterative evaluation of TCO for vaccine carrier technology. This innovative framework facilitates cost-effective assessments and evidence-based decision-making in healthcare settings. By bridging engineering and business perspectives, the TCO framework emerges as a versatile tool, particularly valuable in resource-constrained environments. The tailored toolkit addresses gaps in existing knowledge, enhancing the TCO framework's applicability in diverse healthcare contexts. The study concludes with the researcher providing a comprehensive listing of limitations and offering recommendations for future work. This comprehensive approach, blending theoretical frameworks with practical applications, contributes to the evolving landscape of healthcare decision-making and resource optimization. AFRIKAANSE OPSOMMING: Die toenemende gebruik van entstowwe vereis die identifikasie van nuwe teikengroepe en die uitbreiding van immunisasieaktiwiteite. Hierdie uitbreiding bring dikwels uitdagings mee in gebiede met ontoereikende infrastruktuur en kouekettingnetwerke om entstofdraertegnologie deur sy lewensiklus te ondersteun. Gesondheidsorgverskaffers ervaar moeilikhede om entstoftegnologie te omhels as gevolg van 'n gebrek aan begrip van die geassosieerde lewensikluskoste. Mediese verspreiders staar soortgelyke uitdagings in die gesig as gevolg van 'n gebrek aan bewustheid van die totale koste implikasies wat verband hou met elke entstofdraer deur sy hele lewensiklus. Ten einde hierdie bekommernisse aan te spreek, is die Totale Koste van Eienaarskap (TKE) geïdentifiseer as 'n instrument om gesondheidsorgverskaffers te help om die lewensvatbaarheid van entstoftegnologie-aanvaarding deur sy lewensiklus te verstaan. Hierdie navorsing beoog om 'n deeglike konseptuele raamwerk en instrument te ontwikkel vir die evaluering van die TKE van entstofdraertegnologieë. Die studie skets sewe spesifieke doelwitte wat vertaal is na 'n navorsingsontwerp gebaseer op die ses Ontwerpwetenskapnavorsingsmetodologie (OWNM) aktiwiteite. Die aanvanklike fase behels probleemidentifikasie, met 'n duidelike definisie van die probleem, die vasstelling van doelwitte, en 'n deeglike literatuurstudie. Die literatuurstudie ondersoek bestaande modelle en raamwerke, analiseer sleutelmetodologieë, en oorweeg relevante definisies, konsepte, beginsels, en parameters om die grondslag te lê vir verdere navorsingsontwikkeling. 'n Ingewikkelder TKE Raamwerk is daarna geformuleer wat die ontwerpproses uiteengesit het, met identifisering van sleutelkonsepte, beginsels, en kostekategorieë, deur gebruik te maak van bestaande literatuurgebaseerde TKE-metodes. Spesifieke ontwerpvereistes is tydens die aanvanklike fase vasgestel om kriteria te stel vir die deeglike kalibrasie van die Ingewikkelder TKE Raamwerk en instrument. Die navorsing het semi-gestruktureerde onderhoude met bedryfskundiges ingesluit om die eerste weergawe van die TKE Raamwerk te valideer en te verbeter. Die doel was om te verseker dat konsepte, beginsels, en metodologieë belyn is met werklike toepassings, wat 'n kwalitatiewe analise fasiliteer. Volgens die Ontwerpwetenskapnavorsingsmetodologie (OWNM) het die verfynde raamwerk 'n omvattende hersiening en integrasie van kwalitatiewe uitsette ondergaan. 'n Instrument vir die evaluering van TKE deur middel van gevallestudie-analise is binne die studie uitgestippel. Gevallestudienavorsing is daarna gebruik om die verfynende TKE Raamwerk en instrument te evalueer, met uitdruklike kriteria ooreenstemmend met die OWNMs. Die transformerende bydrae van hierdie navorsing lê in die integrasie van Ontwerpwetenskapnavorsing, wat lei tot 'n Ingewikkelder raamwerk vir die iteratiewe evaluering van lewensikluskoste van entstofdraers. Hierdie innoverende raamwerk fasiliteer koste-effektiewe assesserings en bewysgebaseerde besluitneming in gesondheidsorgomgewings. Deur ingenieurs- en besigheidsperspektiewe te oorbrug, blyk die TKEraamwerk 'n veelsydige hulpmiddel te wees, veral waardevol in omgewings met beperkte hulpbronne. Die aangepaste instrument spreek leemtes aan in bestaande kennis, wat die toepaslikheid van die TKE-raamwerk in uiteenlopende gesondheidsorgkontekste verbeter. Die studie sluit af met die navorser wat 'n omvattende lys van beperkings bied en aanbevelings vir toekomstige werk doen. Hierdie omvattende benadering, waar teoretiese raamwerke met praktiese toepassings vermeng word, dra by tot die evoluerende landskap van gesondheidsorgbesluitneming en hulpbronoptimering. Masters 2024-02-12T13:43:09Z 2024-04-27T02:38:43Z 2024-02-12T13:43:09Z 2024-04-27T02:38:43Z 2023-11 Thesis https://scholar.sun.ac.za/handle/10019.1/130686 en_ZA en_ZA Stellenbosch University xvii, 198 pages : illustrations. application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | Vaccines industry -- Technological innovations Medical technology Life cycle costing UCTD Manuel, Joel Wade A framework for evaluating the TCO of vaccine carrier technology. |
| title | A framework for evaluating the TCO of vaccine carrier technology. |
| title_full | A framework for evaluating the TCO of vaccine carrier technology. |
| title_fullStr | A framework for evaluating the TCO of vaccine carrier technology. |
| title_full_unstemmed | A framework for evaluating the TCO of vaccine carrier technology. |
| title_short | A framework for evaluating the TCO of vaccine carrier technology. |
| title_sort | framework for evaluating the tco of vaccine carrier technology |
| topic | Vaccines industry -- Technological innovations Medical technology Life cycle costing UCTD |
| url | https://scholar.sun.ac.za/handle/10019.1/130686 |
| work_keys_str_mv | AT manueljoelwade aframeworkforevaluatingthetcoofvaccinecarriertechnology AT manueljoelwade frameworkforevaluatingthetcoofvaccinecarriertechnology |