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Exploring neonatal haemochromatosis and gestational alloimmune liver disease: a case series from a South African Tertiary Hospital
Thesis (MMed)--Stellenbosch University, 2024.
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| Format: | Thesis |
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Stellenbosch : Stellenbosch University
2025
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| _version_ | 1867614065852940288 |
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| access_status_str | Open Access |
| author | Ganesan, Anika |
| author2 | Du Buisson, C. J.
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| author_browse | Du Buisson, C. J.
Ganesan, Anika |
| author_facet | Du Buisson, C. J.
Ganesan, Anika |
| author_sort | Ganesan, Anika |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description |
Thesis (MMed)--Stellenbosch University, 2024. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/131785 |
| institution | Stellenbosch University (South Africa) |
| last_indexed | 2026-06-10T12:46:07.073Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/131785 Exploring neonatal haemochromatosis and gestational alloimmune liver disease: a case series from a South African Tertiary Hospital Ganesan, Anika Du Buisson, C. J. Kali, G. Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Paediatrics and Child Health. Liver -- Diseases Neonatal infections Hemochromatosis Pregnancy -- Complications UCTD Thesis (MMed)--Stellenbosch University, 2024. ENGLISH ABSTRACT: The study aims to elucidate the clinical presentation, diagnosis, and treatment outcomes of infants with gestational alloimmune liver disease (GALD) and neonatal hemochromatosis (NH). It also seeks to highlight the importance of early recognition and management to improve survival rates in affected neonates. This case series involves a comprehensive review of clinical data from infants diagnosed with GALD-NH over a seven-year period. Data were collected from electronic case records and included clinical presentation, laboratory findings, treatment protocols, and outcomes. Diagnostic criteria included liver biopsy findings, immunohistochemical staining for C5b-9, and the presence of extrahepatic siderosis. Treatment protocols consisted of double-volume exchange transfusion followed by high-dose intravenous immunoglobulin (IVIG). The study identified four cases of GALD-NH. Affected neonates commonly presented with evidence of liver failure shortly after birth, often accompanied by multiorgan failure. Laboratory findings included marked coagulopathy, hyperammonemia, hypoglycemia, hypoalbuminemia, and significant hyperbilirubinemia. Elevated serum α-fetoprotein and iron studies revealed hypersaturation of transferrin and significant hyperferritinemia. Renal findings included persistent anuria, elevated creatinine levels, and normal-sized kidneys on ultrasound without congenital abnormalities. Some infants required peritoneal dialysis due to fluid overload and renal failure. Histopathological examination showed iron deposition in the renal tubular epithelium. AFRIKAANSE OPSOMMING: Geen opsomming beskikbaar. Masters 2025-03-24T09:40:33Z 2025-03-24T09:40:33Z 2024-12 Thesis https://scholar.sun.ac.za/handle/10019.1/131785 Stellenbosch University 34 pages : illustrations application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | Liver -- Diseases Neonatal infections Hemochromatosis Pregnancy -- Complications UCTD Ganesan, Anika Exploring neonatal haemochromatosis and gestational alloimmune liver disease: a case series from a South African Tertiary Hospital |
| title | Exploring neonatal haemochromatosis and gestational alloimmune liver disease: a case series from a South African Tertiary Hospital |
| title_full | Exploring neonatal haemochromatosis and gestational alloimmune liver disease: a case series from a South African Tertiary Hospital |
| title_fullStr | Exploring neonatal haemochromatosis and gestational alloimmune liver disease: a case series from a South African Tertiary Hospital |
| title_full_unstemmed | Exploring neonatal haemochromatosis and gestational alloimmune liver disease: a case series from a South African Tertiary Hospital |
| title_short | Exploring neonatal haemochromatosis and gestational alloimmune liver disease: a case series from a South African Tertiary Hospital |
| title_sort | exploring neonatal haemochromatosis and gestational alloimmune liver disease a case series from a south african tertiary hospital |
| topic | Liver -- Diseases Neonatal infections Hemochromatosis Pregnancy -- Complications UCTD |
| url | https://scholar.sun.ac.za/handle/10019.1/131785 |
| work_keys_str_mv | AT ganesananika exploringneonatalhaemochromatosisandgestationalalloimmuneliverdiseaseacaseseriesfromasouthafricantertiaryhospital |