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Viral respiratory co-infection in children with presumptive pulmonary TB - a longitudinal study in the pre and post COVID era
Thesis (MMed)--Stellenbosch University, 2024.
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Stellenbosch : Stellenbosch University
2025
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| _version_ | 1867613761079083008 |
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| access_status_str | Open Access |
| author | Makomba, Robin Sande Aheebla |
| author2 | Van der Zalm, Marieke M. |
| author_browse | Makomba, Robin Sande Aheebla Van der Zalm, Marieke M. |
| author_facet | Van der Zalm, Marieke M. Makomba, Robin Sande Aheebla |
| author_sort | Makomba, Robin Sande Aheebla |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description |
Thesis (MMed)--Stellenbosch University, 2024. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/131814 |
| institution | Stellenbosch University (South Africa) |
| last_indexed | 2026-06-10T12:41:16.700Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/131814 Viral respiratory co-infection in children with presumptive pulmonary TB - a longitudinal study in the pre and post COVID era Makomba, Robin Sande Aheebla Van der Zalm, Marieke M. Goussard, Pierre Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Paediatrics and Child Health. Respiratory infections in children Pediatric infectious diseases Tuberculosis in children Virus diseases in children -- Complications UCTD Thesis (MMed)--Stellenbosch University, 2024. ENGLISH ABSTRACT: Background: Limited data are available regarding the prevalence of viral co-infections in children with pulmonary tuberculosis (PTB). The aim of the study is to describe the prevalence of respiratory viruses in children with presumptive PTB before and during the COVID-19 pandemic. Materials and methods: Children <13 years with presumptive PTB, and healthy controls were recruited and followed up between January 2018 and May 2022 in Cape Town, South Africa. Nasopharyngeal aspirates (NPAs) in children with TB (confirmed and unconfirmed), symptomatic controls (TB excluded) and healthy controls were obtained at study enrolment, week 2, 8 and 24 and tested for common respiratory viruses using Multiplex PCR including SARS-CoV-2. Results: Three hundred and ninety children were included in the study, 40.8% children with confirmed and unconfirmed PTB, 46% symptomatic controls and 13% healthy controls. The median age was 28.4 (interquartile range {IQR} 12.2-57.5) months, 8% living with HIV and 29% HIV exposed. Respiratory viruses were detected in 89.8% of samples at baseline with human rhinoviruses (HRV) (69.9%) and human adenoviruses (AdV) (51.4%) being the most prevalent. HRV and AdV remained the most detected viruses throughout the pandemic. There were no differences in viral prevalence or viral subtypes between study groups. Post-pandemic, respiratory syncytial virus A/B was seen in higher prevalence throughout the year and other viruses detected less frequently. Conclusion: A high burden of respiratory viruses was seen in children with presumptive PTB and healthy controls, with changes in prevalence and seasonality in some respiratory viruses during the pandemic. AFRIKAANSE OPSOMMING: Geen opsomming beskikbaar. Masters 2025-03-31T06:49:47Z 2025-03-31T06:49:47Z 2024-12 Thesis https://scholar.sun.ac.za/handle/10019.1/131814 Stellenbosch University 71 pages : illustrations application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | Respiratory infections in children Pediatric infectious diseases Tuberculosis in children Virus diseases in children -- Complications UCTD Makomba, Robin Sande Aheebla Viral respiratory co-infection in children with presumptive pulmonary TB - a longitudinal study in the pre and post COVID era |
| title | Viral respiratory co-infection in children with presumptive pulmonary TB - a longitudinal study in the pre and post COVID era |
| title_full | Viral respiratory co-infection in children with presumptive pulmonary TB - a longitudinal study in the pre and post COVID era |
| title_fullStr | Viral respiratory co-infection in children with presumptive pulmonary TB - a longitudinal study in the pre and post COVID era |
| title_full_unstemmed | Viral respiratory co-infection in children with presumptive pulmonary TB - a longitudinal study in the pre and post COVID era |
| title_short | Viral respiratory co-infection in children with presumptive pulmonary TB - a longitudinal study in the pre and post COVID era |
| title_sort | viral respiratory co infection in children with presumptive pulmonary tb a longitudinal study in the pre and post covid era |
| topic | Respiratory infections in children Pediatric infectious diseases Tuberculosis in children Virus diseases in children -- Complications UCTD |
| url | https://scholar.sun.ac.za/handle/10019.1/131814 |
| work_keys_str_mv | AT makombarobinsandeaheebla viralrespiratorycoinfectioninchildrenwithpresumptivepulmonarytbalongitudinalstudyinthepreandpostcovidera |