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Perioperative outcomes of women with advanced ovarian cancer: A comparison of two historic cohorts at Tygerberg Academic Hospital
Thesis (MMed) -- Stellenbosch University, 2024.
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Stellenbosch : Stellenbosch University
2025
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| _version_ | 1867614117547737088 |
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| access_status_str | Open Access |
| author | Phakathi, Nomkhosi Lungile |
| author2 | Botha, Matthys Hendrik |
| author_browse | Botha, Matthys Hendrik Phakathi, Nomkhosi Lungile |
| author_facet | Botha, Matthys Hendrik Phakathi, Nomkhosi Lungile |
| author_sort | Phakathi, Nomkhosi Lungile |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description |
Thesis (MMed) -- Stellenbosch University, 2024. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/131886 |
| institution | Stellenbosch University (South Africa) |
| last_indexed | 2026-06-10T12:46:56.603Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/131886 Perioperative outcomes of women with advanced ovarian cancer: A comparison of two historic cohorts at Tygerberg Academic Hospital Phakathi, Nomkhosi Lungile Botha, Matthys Hendrik Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. Obstetrics and Gynaecology. Ovaries -- Cancer -- Patients -- South Africa Operating room nursing -- South Africa Cancer -- Surgery -- South Africa UCTD Thesis (MMed) -- Stellenbosch University, 2024. ENGLISH ABSTRACT: Aim: To review the perioperative mortality and morbidity in the treatment of stage IIIC/IV epithelial ovarian cancer by comparing the number and the type of perioperative complications occurring in patients who were treated with primary cytoreduction followed by chemotherapy vs patients who were treated with neoadjuvant therapy followed by interval debulking surgery. Method: It is a quantitative descriptive retrospective study that will compare two cohort groups. The first group will consist of patients that were treated with primary cytoreduction followed by chemotherapy between 2007 to 2010. The second group will consist of patients that were subjected to neoadjuvant chemotherapy before cytoreduction between 2017 and 2020. Approximately 50 patients are diagnosed with and treated at Tygerberg Academic Hospital per year. Women who were admitted to Tygerberg Academic Hospital with stage IIIC/IV epithelial ovarian cancer in a period between 2007 and 2010 and 2017 to 2020. The study was conducted at the oncology unit which serves as a secondary and tertiary referral Centre. The drainage area has a catchment population of 2.5-3 million. The population size will be 60 per group. All patients with advanced ovarian cancer who were diagnosed in the specified period were included in the study. Data was collected using a data collection tool from the patients' files and oncology booklets. Participants were allocated numbers to maintain confidentiality and anonymity. Perioperative parameters that determine survival were looked at. Results: The mean age of patients at diagnosis was 50-59. Most of them were postmenopausal. Eighteen percent had a family history of breast and/or ovarian cancer. Most of the patients did not have co-morbid conditions and had a good functional status (ASA1). Patients were mostly diagnosed with stage IIIc disease. They had a good nutritional status as indicated by haemoglobin and a good renal function. The study showed that patients who received neoadjuvant therapy had a higher chance of complete cytoreduction at surgery and that the blood loss was less than in patients who had primary cytoreduction. However, there was increased chance of adhesions in the NACT. Conclusion: Ovarian cancer has the highest mortality among the gynaecological malignancies. It is often diagnosed when patients have advanced disease already, as it does not have specific symptoms. There are no screening tests. The standard of care is primary surgery with the aim of removing all visible tumor R0. However, if the tumour cannot be completely excised at surgery, neoadjuvant chemotherapy has a role to play. Identifying and optimizing patients before surgery can assist in improving the perioperative morbidity and mortality. AFRIKAANSE OPSOMMING: Geen opsomming beskikbaar. Masters 2025-04-07T09:31:17Z 2025-04-07T09:31:17Z 2024-12 Thesis https://scholar.sun.ac.za/handle/10019.1/131886 Stellenbosch University xii, 37 pages : illustrations application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | Ovaries -- Cancer -- Patients -- South Africa Operating room nursing -- South Africa Cancer -- Surgery -- South Africa UCTD Phakathi, Nomkhosi Lungile Perioperative outcomes of women with advanced ovarian cancer: A comparison of two historic cohorts at Tygerberg Academic Hospital |
| title | Perioperative outcomes of women with advanced ovarian cancer: A comparison of two historic cohorts at Tygerberg Academic Hospital |
| title_full | Perioperative outcomes of women with advanced ovarian cancer: A comparison of two historic cohorts at Tygerberg Academic Hospital |
| title_fullStr | Perioperative outcomes of women with advanced ovarian cancer: A comparison of two historic cohorts at Tygerberg Academic Hospital |
| title_full_unstemmed | Perioperative outcomes of women with advanced ovarian cancer: A comparison of two historic cohorts at Tygerberg Academic Hospital |
| title_short | Perioperative outcomes of women with advanced ovarian cancer: A comparison of two historic cohorts at Tygerberg Academic Hospital |
| title_sort | perioperative outcomes of women with advanced ovarian cancer a comparison of two historic cohorts at tygerberg academic hospital |
| topic | Ovaries -- Cancer -- Patients -- South Africa Operating room nursing -- South Africa Cancer -- Surgery -- South Africa UCTD |
| url | https://scholar.sun.ac.za/handle/10019.1/131886 |
| work_keys_str_mv | AT phakathinomkhosilungile perioperativeoutcomesofwomenwithadvancedovariancanceracomparisonoftwohistoriccohortsattygerbergacademichospital |