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The effect of human immunodeficiency virus on the clinical course and treatment of gestational trophoblastic disease
Thesis (MMed) -- Stellenbosch University, 2025.
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Stellenbosch : Stellenbosch University
2025
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| _version_ | 1867614092466847744 |
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| access_status_str | Open Access |
| author | Burns, Lucinda Carmen |
| author2 | Butt, Jennifer |
| author_browse | Burns, Lucinda Carmen Butt, Jennifer |
| author_facet | Butt, Jennifer Burns, Lucinda Carmen |
| author_sort | Burns, Lucinda Carmen |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description | Thesis (MMed) -- Stellenbosch University, 2025. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/132093 |
| institution | Stellenbosch University (South Africa) |
| last_indexed | 2026-06-10T12:46:32.674Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/132093 The effect of human immunodeficiency virus on the clinical course and treatment of gestational trophoblastic disease Burns, Lucinda Carmen Butt, Jennifer Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Obstetrics and Gynaecology. Thesis (MMed) -- Stellenbosch University, 2025. Burns, L. 2025. The effect of human immunodeficiency virus on the clinical course and treatment of gestational trophoblastic disease. Unpublished masters thesis. Stellenbosch: Stellenbosch University [online]. Available: https://scholar.sun.ac.za/items/dac1c048-e44e-41b3-ad00-840522f023a9 Objectives: The objective of the study was to describe the HIV-positive patients with gestational trophoblastic disease and to determine whether it is safe to adopt a shorter surveillance strategy in these patients. Methods: This was a retrospective descriptive study carried out at the Gynaecologic Oncology unit at Tygerberg Hospital. All cases of Gestational trophoblastic disease registered and managed at this unit over a 4-year period from 1st January 2017 to 31st December 2020 were included in the study. Results: Ninety one women were diagnosed with GTD. Fourteen patients were excluded from the analysis. The mean age of the patients was 31.6 years. All patients had a known HIV status, eleven (14.2%) were HIV-positive and sixty-six (85.7%) were HIV-negative. The presenting features did not differ between HIV-positive and negative patients. Histologically, fifteen patients (19.5%) had partial moles and 60 patients (77.8%) had complete moles. There was no difference in type of gestational trophoblastic disease between HIV-positive and HIV-negative patients (p=0.343). At 56 days after evacuation of the molar pregnancy, none of the HIV positive patients’ BhCG level was <5mIU/ml. There was a significant difference in the mean time to BhCG< 5mIU/ml between HIV positive and negative women (p=0.009). PTN occurred in 16.9 % (13) of the 77 included women and 9.1% had choriocarcinoma. All persistent disease resolved after chemotherapy. Conclusion: A shorter BhCG follow up time of 6 months post evacuation of a complete molar pregnancy can be adopted in HIV-positive patients. In our study, however, none of the HIV-positive patients met the criteria of BhCG < 5 within 56 days for this shorter follow up to be beneficial. There were not enough HIV-positive patients with partial moles for meaningful analysis. It is essential that all patients be advised to adhere to BhCG follow up, especially in HIV-positive women where the follow up may be lengthy. Masters 2025-05-23T07:49:37Z 2025-05-23T07:49:37Z 2025-03 Thesis https://scholar.sun.ac.za/handle/10019.1/132093 Stellenbosch University 30 pages application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | Burns, Lucinda Carmen The effect of human immunodeficiency virus on the clinical course and treatment of gestational trophoblastic disease |
| title | The effect of human immunodeficiency virus on the clinical course and treatment of gestational trophoblastic disease |
| title_full | The effect of human immunodeficiency virus on the clinical course and treatment of gestational trophoblastic disease |
| title_fullStr | The effect of human immunodeficiency virus on the clinical course and treatment of gestational trophoblastic disease |
| title_full_unstemmed | The effect of human immunodeficiency virus on the clinical course and treatment of gestational trophoblastic disease |
| title_short | The effect of human immunodeficiency virus on the clinical course and treatment of gestational trophoblastic disease |
| title_sort | effect of human immunodeficiency virus on the clinical course and treatment of gestational trophoblastic disease |
| url | https://scholar.sun.ac.za/handle/10019.1/132093 |
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