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Prevalence of and factors associated with carbapenem resistant Enterobacterales rectal colonisation in hospitalised neonates in the Western Cape Province, South Africa
Thesis (MMed)--Stellenbosch University, 2025.
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| Format: | Thesis |
| Language: | English |
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Stellenbosch : Stellenbosch University
2025
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| _version_ | 1867613779583303680 |
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| access_status_str | Open Access |
| author | Haumann, Michele Esme |
| author2 | Bekker, Adrie |
| author_browse | Bekker, Adrie Haumann, Michele Esme |
| author_facet | Bekker, Adrie Haumann, Michele Esme |
| author_sort | Haumann, Michele Esme |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description | Thesis (MMed)--Stellenbosch University, 2025. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/133110 |
| institution | Stellenbosch University (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:41:34.416Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/133110 Prevalence of and factors associated with carbapenem resistant Enterobacterales rectal colonisation in hospitalised neonates in the Western Cape Province, South Africa Haumann, Michele Esme Bekker, Adrie Dramowski, Angela Geldenhuys, Chandre O'Connell, N. Whitelaw, Andrew Esterhuizen, Tonya Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Paediatrics and Child Health. Enterobacteriaceae -- Molecular aspects -- Western Cape (South Africa) Drug resistance in microorganisms -- Western Cape (South Africa) Competitive exclusion (Microbiology) -- Western Cape (South Africa) Newborn infants -- Diseases -- Western Cape (South Africa) Thesis (MMed)--Stellenbosch University, 2025. Haumann, M. E. 2025. Prevalence of and factors associated with carbapenem resistant Enterobacterales rectal colonisation in hospitalised neonates in the Western Cape Province, South Africa. Unpublished masters thesis. Stellenbosch: Stellenbosch University [online]. Available: https://scholar.sun.ac.za/items/1eae1f24-cb03-456c-b218-3cc7a2c42520 The published article is available at https://sajid.co.za/index.php/sajid/article/view/726/1807 ENGLISH ABSTRACT: Background: Carbapenem resistant Enterobacterales (CRE) have emerged as major healthcare-associated infection (HAI) pathogens globally with substantial associated mortality and morbidity. The factors associated with rectal colonisation with CRE in hospitalised neonates in resource-limited settings are not well understood. Methods: We conducted a retrospective cohort study to determine the prevalence of rectal CRE colonisation in neonates referred from a central hospital, to a regional and a district hospital in the Western Cape Province of South Africa (1 March 2019-30 September 2020). Clinical data and laboratory records were reviewed to identify possible factors associated with CRE colonisation using stepwise forward logistic regression analysis. Results: Among 291 neonates transferred to the regional and district hospitals, the median birth weight and gestational age were 1360 (IQR 1080-1690) grams and 31 (IQR 29-33) weeks. Overall CRE rectal colonisation prevalence at the time of transfer from the central hospital was 22.3% (65/291), with colonising species including Klebsiella pneumoniae (59/65, 90.8%) and Serratia marcescens (6/65; 9.2%). There were no factors significantly associated with CRE colonisation. No CRE colonised neonate subsequently developed CRE infection. Post discharge mortality rates were similar in the CRE colonised versus the non-colonised neonates (2/65 [3.1%] vs 9/226 [4.0%]; p = 0.737). Conclusion: Rectal colonisation with CRE was highly prevalent in preterm neonates being transferred for step-down hospital care. CRE colonised neonates had similar demographic characteristics to non-colonised neonates with no factors significantly associated with CRE colonisation. There was no increased risk of subsequent CRE infection or mortality in the 12 months post-discharge in neonates who were CRE colonised at hospital transfer. AFRIKAANSE OPSOMMING: Geen opsomming beskikbaar. Masters 2025-07-18T06:31:54Z 2025-07-18T06:31:54Z 2025-03 Thesis https://scholar.sun.ac.za/handle/10019.1/133110 en Stellenbosch University 42 pages application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | Enterobacteriaceae -- Molecular aspects -- Western Cape (South Africa) Drug resistance in microorganisms -- Western Cape (South Africa) Competitive exclusion (Microbiology) -- Western Cape (South Africa) Newborn infants -- Diseases -- Western Cape (South Africa) Haumann, Michele Esme Prevalence of and factors associated with carbapenem resistant Enterobacterales rectal colonisation in hospitalised neonates in the Western Cape Province, South Africa |
| title | Prevalence of and factors associated with carbapenem resistant Enterobacterales rectal colonisation in hospitalised neonates in the Western Cape Province, South Africa |
| title_full | Prevalence of and factors associated with carbapenem resistant Enterobacterales rectal colonisation in hospitalised neonates in the Western Cape Province, South Africa |
| title_fullStr | Prevalence of and factors associated with carbapenem resistant Enterobacterales rectal colonisation in hospitalised neonates in the Western Cape Province, South Africa |
| title_full_unstemmed | Prevalence of and factors associated with carbapenem resistant Enterobacterales rectal colonisation in hospitalised neonates in the Western Cape Province, South Africa |
| title_short | Prevalence of and factors associated with carbapenem resistant Enterobacterales rectal colonisation in hospitalised neonates in the Western Cape Province, South Africa |
| title_sort | prevalence of and factors associated with carbapenem resistant enterobacterales rectal colonisation in hospitalised neonates in the western cape province south africa |
| topic | Enterobacteriaceae -- Molecular aspects -- Western Cape (South Africa) Drug resistance in microorganisms -- Western Cape (South Africa) Competitive exclusion (Microbiology) -- Western Cape (South Africa) Newborn infants -- Diseases -- Western Cape (South Africa) |
| url | https://scholar.sun.ac.za/handle/10019.1/133110 |
| work_keys_str_mv | AT haumannmicheleesme prevalenceofandfactorsassociatedwithcarbapenemresistantenterobacteralesrectalcolonisationinhospitalisedneonatesinthewesterncapeprovincesouthafrica |