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The neuropsychiatry and neuropsychology of Lipoid Proteinosis
Thesis (PhD (Psychiatry))--University of Stellenbosch, 2006.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Stellenbosch : University of Stellenbosch
2008
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| _version_ | 1867614034438651904 |
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| access_status_str | Open Access |
| author | Thornton, H. B. |
| author2 | Stein, D. J. |
| author_browse | Stein, D. J. Thornton, H. B. |
| author_facet | Stein, D. J. Thornton, H. B. |
| author_sort | Thornton, H. B. |
| collection | Thesis |
| dc_rights_str_mv | University of Stellenbosch |
| description | Thesis (PhD (Psychiatry))--University of Stellenbosch, 2006. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/1362 |
| institution | Stellenbosch University (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:45:37.487Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2008 |
| publishDateRange | 2008 |
| publishDateSort | 2008 |
| publisher | Stellenbosch : University of Stellenbosch |
| publisherStr | Stellenbosch : University of Stellenbosch |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/1362 The neuropsychiatry and neuropsychology of Lipoid Proteinosis Thornton, H. B. Stein, D. J. Baker, G. A. University of Stellenbosch. Faculty of Health Sciences. Dept. of Psychiatry. Lipidoses -- South Africa Neuropsychiatry Dissertations -- Psychiatry Theses -- Psychiatry Thesis (PhD (Psychiatry))--University of Stellenbosch, 2006. Lipoid Proteinosis (LiP) is a rare hereditary disease, which often results in bilateral, symmetrical and circumscribed calcifications in the mesial temporal region (especially the amygdala). While several case studies have been published on individuals with this illness, there have been few systematic investigations of the neuropsychiatry and neuropsychology of a series of patients. Thirty-seven LiP patients were extensively assessed with standardized neuropsychiatric and neuropsychological measures. Of these, 27 patients from the Northern Cape in South Africa were matched (for age, gender, education, language, geographical area) with 53 controls. There was a high incidence of neuropsychiatric disorders in LiP (more than half of the subjects reported a history of depression or anxiety and 12% had a diagnosis of schizophrenia). Despite a wide variance, LiP subjects performed poorly on facial recognition for emotions and on most neuropsychological measures including intelligence, recall and executive functioning. These findings are consistent with involvement of the mesial temporal areas in mood, anxiety, and psychotic symptoms, and in the cognitive-affective processes. Future work aimed at delineating the associations between the clinical and neuropsychological findings reported here, for example, with brain-imaging techniques, is needed. Doctoral 2008-08-04T10:05:41Z 2010-06-01T08:19:35Z 2008-08-04T10:05:41Z 2010-06-01T08:19:35Z 2006-12 Thesis http://hdl.handle.net/10019.1/1362 en University of Stellenbosch application/pdf Stellenbosch : University of Stellenbosch |
| spellingShingle | Lipidoses -- South Africa Neuropsychiatry Dissertations -- Psychiatry Theses -- Psychiatry Thornton, H. B. The neuropsychiatry and neuropsychology of Lipoid Proteinosis |
| title | The neuropsychiatry and neuropsychology of Lipoid Proteinosis |
| title_full | The neuropsychiatry and neuropsychology of Lipoid Proteinosis |
| title_fullStr | The neuropsychiatry and neuropsychology of Lipoid Proteinosis |
| title_full_unstemmed | The neuropsychiatry and neuropsychology of Lipoid Proteinosis |
| title_short | The neuropsychiatry and neuropsychology of Lipoid Proteinosis |
| title_sort | neuropsychiatry and neuropsychology of lipoid proteinosis |
| topic | Lipidoses -- South Africa Neuropsychiatry Dissertations -- Psychiatry Theses -- Psychiatry |
| url | http://hdl.handle.net/10019.1/1362 |
| work_keys_str_mv | AT thorntonhb theneuropsychiatryandneuropsychologyoflipoidproteinosis AT thorntonhb neuropsychiatryandneuropsychologyoflipoidproteinosis |