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A study of non-alcoholic fatty liver disease (NAFLD) in South African patients and analysis of candidate genes in insulin resistance and fatty acid oxidation.
Thesis (PhD (Medicine. Internal Medicine))--Stellenbosch University, 2008.
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| Format: | Thesis |
| Language: | English |
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Stellenbosch : Stellenbosch University
2008
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| _version_ | 1867613867472846848 |
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| access_status_str | Open Access |
| author | Kruger, F. C. |
| author2 | Kotze, Maritha J. |
| author_browse | Kotze, Maritha J. Kruger, F. C. |
| author_facet | Kotze, Maritha J. Kruger, F. C. |
| author_sort | Kruger, F. C. |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description | Thesis (PhD (Medicine. Internal Medicine))--Stellenbosch University, 2008. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/1415 |
| institution | Stellenbosch University (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:42:57.574Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2008 |
| publishDateRange | 2008 |
| publishDateSort | 2008 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/1415 A study of non-alcoholic fatty liver disease (NAFLD) in South African patients and analysis of candidate genes in insulin resistance and fatty acid oxidation. Kruger, F. C. Kotze, Maritha J. Van Rensburg, C. J. Stellenbosch University. Faculty of Health Sciences. Dept. of Medicine. Internal Medicine. Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Insulin resistance Liver cirrhosis Dissertations -- Internal medicine Theses -- Internal medicine Thesis (PhD (Medicine. Internal Medicine))--Stellenbosch University, 2008. Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease in Western countries, extending from steatosis (FLD) to steatohepatitis (NASH). Differentiation between NASH and nonprogressive NAFLD is difficult on clinical grounds therefore a need exists to identify reliable biomarkers of disease progression. The aims of the study were 1) to describe the disease profile of NAFLD/NASH in South African patients of the Western Cape, 2) to investigate the metabolic derangements associated with this condition, including insulin resistance, lipid abnormalities and liver fibrogenesis, and 3) to assess the possible involvement of candidate genes in relation to the disease phenotype in the patient cohort. A total of 233 patients (73% female) were enrolled in this study, consisting of 69% Cape Coloured, 25% Caucasian, 5% Black and 1% Asian individuals. All subjects were obese or overweight based on the assessment of body mass index (BMI). Screening for NAFLD identified 182 patients (87%) with ultrasonographical evidence of fatty infiltration and/or hepatomegaly. Liver biopsies were performed on patients with persistently abnormal liver functions and/or hepatomegaly. NAFLD was confirmed histologically in 111 patients of whom 36% had NASH and 17% advanced liver fibrosis. None of the Black patients had advanced fibrosis. Doctoral 2008-11-07T13:58:29Z 2010-06-01T08:21:05Z 2008-11-07T13:58:29Z 2010-06-01T08:21:05Z 2008-12 Thesis http://hdl.handle.net/10019.1/1415 en Stellenbosch University application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Insulin resistance Liver cirrhosis Dissertations -- Internal medicine Theses -- Internal medicine Kruger, F. C. A study of non-alcoholic fatty liver disease (NAFLD) in South African patients and analysis of candidate genes in insulin resistance and fatty acid oxidation. |
| title | A study of non-alcoholic fatty liver disease (NAFLD) in South African patients and analysis of candidate genes in insulin resistance and fatty acid oxidation. |
| title_full | A study of non-alcoholic fatty liver disease (NAFLD) in South African patients and analysis of candidate genes in insulin resistance and fatty acid oxidation. |
| title_fullStr | A study of non-alcoholic fatty liver disease (NAFLD) in South African patients and analysis of candidate genes in insulin resistance and fatty acid oxidation. |
| title_full_unstemmed | A study of non-alcoholic fatty liver disease (NAFLD) in South African patients and analysis of candidate genes in insulin resistance and fatty acid oxidation. |
| title_short | A study of non-alcoholic fatty liver disease (NAFLD) in South African patients and analysis of candidate genes in insulin resistance and fatty acid oxidation. |
| title_sort | study of non alcoholic fatty liver disease nafld in south african patients and analysis of candidate genes in insulin resistance and fatty acid oxidation |
| topic | Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Insulin resistance Liver cirrhosis Dissertations -- Internal medicine Theses -- Internal medicine |
| url | http://hdl.handle.net/10019.1/1415 |
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