Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
The role of surfactant in, and a comparison of, the permeability of porcine and human epithelia to various chemical compounds
Thesis (MScMedSc (Pharmacology))--University of Stellenbosch, 2005.
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Stellenbosch : University of Stellenbosch
2008
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867614087977893888 |
|---|---|
| access_status_str | Open Access |
| author | Viljoen, Ianda |
| author2 | Van der Bijl, P. |
| author_browse | Van der Bijl, P. Viljoen, Ianda |
| author_facet | Van der Bijl, P. Viljoen, Ianda |
| author_sort | Viljoen, Ianda |
| collection | Thesis |
| dc_rights_str_mv | University of Stellenbosch |
| description | Thesis (MScMedSc (Pharmacology))--University of Stellenbosch, 2005. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/1852 |
| institution | Stellenbosch University (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:46:28.519Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2008 |
| publishDateRange | 2008 |
| publishDateSort | 2008 |
| publisher | Stellenbosch : University of Stellenbosch |
| publisherStr | Stellenbosch : University of Stellenbosch |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/1852 The role of surfactant in, and a comparison of, the permeability of porcine and human epithelia to various chemical compounds Viljoen, Ianda Van der Bijl, P. University of Stellenbosch. Faculty of Health Sciences. Dept. of Medicine. Pharmacology. Surface active agents Mucous membrane Epithelial cells Permeability Dissertations -- Pharmacology Theses -- Pharmacology Thesis (MScMedSc (Pharmacology))--University of Stellenbosch, 2005. In this thesis, research results are reported on the role of natural and synthetic surfactants on the in vitro permeability characteristics of various chemical compounds across porcine (buccal, bronchial, arterial, venous and rectal) and human (vaginal) tissues. The permeability flux values of the different compounds (arecoline, 17β-estradiol, hydrocortisone, dexamethasone, vasopressin, oxytocin, zidovudine and isoniazid) were determined using a continuous flow-through diffusion system. Mean steady state flux values were compared statistically by means of a t-test at a significance level of 5% as well as an F-test using whole curve comparisons. The results indicated that the synthetic pulmonary surfactant Biopolsurf is an effective enhancer for the permeation of chemical compounds through most of the tissues tested and that molecular weight, electrostatic charge, partitioning of the molecules in surfactant and surfactant concentration play an important role in trans membrane diffusion. In addition the epithelial permeability of the different types of tissues for various chemical compounds (arecoline, 17β-estradiol, hydrocortisone, dexamethasone, vasopressin and oxytocin) across the above tissues were compared. The results obtained showed that the permeability flux values of the compounds across porcine bronchial and human vaginal tissues were consistently similar and that porcine buccal tissue had the lowest permeability of all tissues tested. This was in agreement with previous in vitro studies. It was concluded that a wide variation in the permeability characteristics of different epithelia exists and that the pulmonary epithelium, due to its high permeability, is probably the most effective epithelium for drug delivery purposes, especially for drugs that undergo extensive gastrointestinal or hepatic first-pass metabolism. 2008-08-06T12:20:08Z 2010-06-01T08:34:49Z 2008-08-06T12:20:08Z 2010-06-01T08:34:49Z 2005-12 Thesis http://hdl.handle.net/10019.1/1852 en University of Stellenbosch application/pdf Stellenbosch : University of Stellenbosch |
| spellingShingle | Surface active agents Mucous membrane Epithelial cells Permeability Dissertations -- Pharmacology Theses -- Pharmacology Viljoen, Ianda The role of surfactant in, and a comparison of, the permeability of porcine and human epithelia to various chemical compounds |
| title | The role of surfactant in, and a comparison of, the permeability of porcine and human epithelia to various chemical compounds |
| title_full | The role of surfactant in, and a comparison of, the permeability of porcine and human epithelia to various chemical compounds |
| title_fullStr | The role of surfactant in, and a comparison of, the permeability of porcine and human epithelia to various chemical compounds |
| title_full_unstemmed | The role of surfactant in, and a comparison of, the permeability of porcine and human epithelia to various chemical compounds |
| title_short | The role of surfactant in, and a comparison of, the permeability of porcine and human epithelia to various chemical compounds |
| title_sort | role of surfactant in and a comparison of the permeability of porcine and human epithelia to various chemical compounds |
| topic | Surface active agents Mucous membrane Epithelial cells Permeability Dissertations -- Pharmacology Theses -- Pharmacology |
| url | http://hdl.handle.net/10019.1/1852 |
| work_keys_str_mv | AT viljoenianda theroleofsurfactantinandacomparisonofthepermeabilityofporcineandhumanepitheliatovariouschemicalcompounds AT viljoenianda roleofsurfactantinandacomparisonofthepermeabilityofporcineandhumanepitheliatovariouschemicalcompounds |