Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
Synthesis of permanent non-leaching antimicrobial polymer nanofibers
Thesis (PhD)--Stellenbosch University, 2012.
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | en_ZA |
| Published: |
Stellenbosch : Stellenbosch University
2012
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613984625000448 |
|---|---|
| access_status_str | Open Access |
| author | Bshena, Osama E. S. |
| author2 | Klumperman, Bert |
| author_browse | Bshena, Osama E. S. Klumperman, Bert |
| author_facet | Klumperman, Bert Bshena, Osama E. S. |
| author_sort | Bshena, Osama E. S. |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description | Thesis (PhD)--Stellenbosch University, 2012. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/20160 |
| institution | Stellenbosch University (South Africa) |
| language | en_ZA |
| last_indexed | 2026-06-10T12:44:50.018Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2012 |
| publishDateRange | 2012 |
| publishDateSort | 2012 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/20160 Synthesis of permanent non-leaching antimicrobial polymer nanofibers Bshena, Osama E. S. Klumperman, Bert Stellenbosch University. Faculty of Science. Dept. of Chemistry and Polymer Science. Nanofibers Polymers -- Synthesis Electrospinning Dissertations -- Polymer science Theses -- Polymer science Chemistry and Polymer Science Thesis (PhD)--Stellenbosch University, 2012. ENGLISH ABSTRACT: Antimicrobial fibers are very useful in various fields such as air and water purification, wound dressings and protective bandages, where sterile environments are essential. The nonwoven nanofiber mats or membranes are able to filter out microorganisms and potentially kill several threatening pathogenic bacteria. In this thesis, a variety of styrene-maleimide copolymer derivatives were prepared based on the modification of poly(styrene-co-maleic anhydride with various primary amine compounds. All prepared copolymer derivatives were electrospun to nanofiber mats using the needle electrospinning technique. For the characterization, differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) were used to study the thermal properties of the electrospun fiber mats. Scanning electron microscopy (SEM) was carried out to observe fiber dimensions and morphology. The antibacterial activity of electrospun fiber mats was evaluated against different bacteria including Staphylococcus aureus (Gram-positive), Escherichia coli and Pseudomonas aeruginosa (Gram-negative). The evaluation study utilized different tools to test for antibacterial activity and mode of cell death, including bioluminescent imaging, fluorescence imaging and the viable cell counting method. Excellent antimicrobial activity was obtained against the different strains especially against Staphylococcus aureus. Fiber mats containing tertiary amino groups, phenol or quaternary ammonium groups had the strongest antimicrobial properties. AFRIKAANSE OPSOMMING: Antimikrobiese vesels is baie nuttig in verskeie toepassingsgebiede, soos lug- en watersuiwering, wondbedekkings en beskermende verbande, waar ‘n steriele omgewing noodsaaklik is. Die ongeweefde nanovesel matte of membrane is in staat om mikroorganismes te verwyder deur filtrasie, maar kan ook verskeie patogeniese bakterieë doodmaak. In hierdie proefskrif is ‘n verskeidenheid stireen-maleimied kopolimeer afgeleides gesintetiseer, gebaseer op die modifikasie van poli(stireen-ko-maleïne anhidried) met verskeie primêre amien verbindings. Nanovesel matte van al die gesintetiseerde kopolimeer afgeleides is gemaak deur gebruik te maak van die naald-elektrospin tegniek. Die termiese eienskappe van hierdie nanovesel matte is bestudeer deur gebruik te maak van differensiële skandeer kalorimetrie (DSK) en termogravitasie analiese (TGA) as karakteriseringsmetodes. Die vesel dimensies en morfologie is bestudeer deur skandeer elektronmikroskopie as karakteriseringsmetode te gebruik. Die antibakteriële aktiwiteit van die gespinde vesel matte is geëvalueer teen verskillende bakterieë, naamlik Staphylococcus aureus (Gram-positief), Escherichia coli en Pseudomonas aeruginosa (Gram-negatief). Die evalueringstudie het verskillende instrumente gebruik om vir antibakteriële aktiwiteit en meganisme van seldood te toets, insluitend bioluminiserings beelding, fluoressensie beelding en die lewensvatbare sel tellingsmetode. Uitstekende antimikrobiese aktiwiteit is verkry teen die verskillende rasse, veral teen Staphylococcus aureus. Vesel matte met tersiêre aminogroepe, fenol of kwaternêre ammoniumgroepe het die sterkste antimikrobiese eienskappe gehad. Doctoral 2012-03-13T15:31:34Z 2012-03-30T10:48:14Z 2012-03-13T15:31:34Z 2012-03-30T10:48:14Z 2012-03 Thesis http://hdl.handle.net/10019.1/20160 en_ZA Stellenbosch University application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | Nanofibers Polymers -- Synthesis Electrospinning Dissertations -- Polymer science Theses -- Polymer science Chemistry and Polymer Science Bshena, Osama E. S. Synthesis of permanent non-leaching antimicrobial polymer nanofibers |
| title | Synthesis of permanent non-leaching antimicrobial polymer nanofibers |
| title_full | Synthesis of permanent non-leaching antimicrobial polymer nanofibers |
| title_fullStr | Synthesis of permanent non-leaching antimicrobial polymer nanofibers |
| title_full_unstemmed | Synthesis of permanent non-leaching antimicrobial polymer nanofibers |
| title_short | Synthesis of permanent non-leaching antimicrobial polymer nanofibers |
| title_sort | synthesis of permanent non leaching antimicrobial polymer nanofibers |
| topic | Nanofibers Polymers -- Synthesis Electrospinning Dissertations -- Polymer science Theses -- Polymer science Chemistry and Polymer Science |
| url | http://hdl.handle.net/10019.1/20160 |
| work_keys_str_mv | AT bshenaosamaes synthesisofpermanentnonleachingantimicrobialpolymernanofibers |