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Molecular analysis of genes involved in iron overload implicated in oesophageal cancer
Thesis (MSc (Genetics))--University of Stellenbosch, 2007.
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Stellenbosch : University of Stellenbosch
2007
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| _version_ | 1867613889893498880 |
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| access_status_str | Open Access |
| author | Human, Veronique |
| author2 | Zaahl, M. G. |
| author_browse | Human, Veronique Zaahl, M. G. |
| author_facet | Zaahl, M. G. Human, Veronique |
| author_sort | Human, Veronique |
| collection | Thesis |
| dc_rights_str_mv | University of Stellenbosch |
| description | Thesis (MSc (Genetics))--University of Stellenbosch, 2007. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/2223 |
| institution | Stellenbosch University (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:43:19.203Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2007 |
| publishDateRange | 2007 |
| publishDateSort | 2007 |
| publisher | Stellenbosch : University of Stellenbosch |
| publisherStr | Stellenbosch : University of Stellenbosch |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/2223 Molecular analysis of genes involved in iron overload implicated in oesophageal cancer Human, Veronique Zaahl, M. G. Warnich, L. Erasmus, Rajiv T. University of Stellenbosch. Faculty of Agrisciences. Dept. of Genetics. Dissertations -- Genetics Theses -- Genetics Esophagus -- Cancer -- South Africa -- Genetic aspects Esophagus -- Cancer -- South Africa -- Molecular aspects Iron in the body Thesis (MSc (Genetics))--University of Stellenbosch, 2007. Oesophageal cancer is a disease characterised by a disproportionate presentation in certain ethnic groups, with squamous cell carcinoma (SCC) occuring more often in Blacks and adenocarcinoma (ADC) being more prevalent in Caucasians. Several factors have been attributed to the development of OC, including an excess of iron (leading to enhanced tumour growth), oesophageal injury and chronic inflammation. The main aim of this study was to establish the mutation spectrum of six genes (including HFE, HMOX1, SLC40A1, HAMP, CYBRD1 and HJV) involved in iron metabolism, in the Black South African OC population. The patient cohort comprised of 50 (25 male and 25 female) unrelated patients presenting with SCC of the oesophagus, with the control group consisting of 50 unrelated, healthy population-matched individuals. The mutation detection techniques employed included polymerase chain reaction (PCR) amplification, heteroduplex single-stranded conformational polymorphism (HEX-SSCP) analysis, restriction fragment length polymorphism (RFLP) analysis and bi-directional semi-automated DNA sequencing analysis of variants identified. Masters 2007-11-19T06:31:34Z 2010-06-01T08:43:43Z 2007-11-19T06:31:34Z 2010-06-01T08:43:43Z 2007-03 Thesis http://hdl.handle.net/10019.1/2223 en University of Stellenbosch 1457324 bytes application/pdf application/pdf Stellenbosch : University of Stellenbosch |
| spellingShingle | Dissertations -- Genetics Theses -- Genetics Esophagus -- Cancer -- South Africa -- Genetic aspects Esophagus -- Cancer -- South Africa -- Molecular aspects Iron in the body Human, Veronique Molecular analysis of genes involved in iron overload implicated in oesophageal cancer |
| title | Molecular analysis of genes involved in iron overload implicated in oesophageal cancer |
| title_full | Molecular analysis of genes involved in iron overload implicated in oesophageal cancer |
| title_fullStr | Molecular analysis of genes involved in iron overload implicated in oesophageal cancer |
| title_full_unstemmed | Molecular analysis of genes involved in iron overload implicated in oesophageal cancer |
| title_short | Molecular analysis of genes involved in iron overload implicated in oesophageal cancer |
| title_sort | molecular analysis of genes involved in iron overload implicated in oesophageal cancer |
| topic | Dissertations -- Genetics Theses -- Genetics Esophagus -- Cancer -- South Africa -- Genetic aspects Esophagus -- Cancer -- South Africa -- Molecular aspects Iron in the body |
| url | http://hdl.handle.net/10019.1/2223 |
| work_keys_str_mv | AT humanveronique molecularanalysisofgenesinvolvedinironoverloadimplicatedinoesophagealcancer |