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The influence of sex chromosomes on the outcome of human embryo development
Thesis (MScMedSc (Obstetrics and Gynaecology))--University of Stellenbosch, 2005.
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| Format: | Thesis |
| Language: | English |
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Stellenbosch : University of Stellenbosch
2008
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| _version_ | 1867613877825437696 |
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| access_status_str | Open Access |
| author | Raja, Kimenthra |
| author2 | Franken, Daniel R. |
| author_browse | Franken, Daniel R. Raja, Kimenthra |
| author_facet | Franken, Daniel R. Raja, Kimenthra |
| author_sort | Raja, Kimenthra |
| collection | Thesis |
| dc_rights_str_mv | University of Stellenbosch |
| description | Thesis (MScMedSc (Obstetrics and Gynaecology))--University of Stellenbosch, 2005. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/2378 |
| institution | Stellenbosch University (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:43:08.148Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2008 |
| publishDateRange | 2008 |
| publishDateSort | 2008 |
| publisher | Stellenbosch : University of Stellenbosch |
| publisherStr | Stellenbosch : University of Stellenbosch |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/2378 The influence of sex chromosomes on the outcome of human embryo development Raja, Kimenthra Franken, Daniel R. Esterhuizen, Aldo E. University of Stellenbosch. Faculty of Health Sciences. Dept. of Obstetrics and Gynaecology. Human reproduction Conception Human embryo Sex chromosomes Dissertations -- Medicine Theses -- Medicine Dissertations -- Obstetrics and gynaecology Theses -- Obstetrics and gynaecology Thesis (MScMedSc (Obstetrics and Gynaecology))--University of Stellenbosch, 2005. CHAPTER 1 presents comprehensive background information regarding all aspects addressed in this thesis. Special attention was given to literature on paternal influences on embryonic development, the role of sperm RNA, sperm chromatin and sperm functional aspects i.e. morphology and acrosomal status and size. The experimental design and all relevant methods used during the study as well as the material that were used are presented in CHAPTER 2. The results of the different techniques and evaluations are provided in CHAPTER 3. It was found that 70% of the embryos that showed no developmental potential were Y-chromosome bearing embryos. The sperm selection process for ICSI based on the approach of choosing the “best looking“ spermatozoon in the ejaculate seem to provide cells that can be classified as normal based on the length width ratio set by the WHO for normal cells. The chromatin packaging quality of the sperm correlated significantly and negatively with the percentage normal cells in the ejaculates. CHAPTER 4 comprises of a general discussion of the results and short summary of the major findings during the project. The discussion section focused on the paternal influence on the embryonic development and provided a suggestion for future research that can possibly lead to the use of X-chromosome bearing sperm in case of severe male factor cases. CHAPTER 5 contains the bibliographical information of the study. 2008-07-24T12:35:06Z 2010-06-01T08:47:23Z 2008-07-24T12:35:06Z 2010-06-01T08:47:23Z 2005-12 Thesis http://hdl.handle.net/10019.1/2378 en University of Stellenbosch application/pdf Stellenbosch : University of Stellenbosch |
| spellingShingle | Human reproduction Conception Human embryo Sex chromosomes Dissertations -- Medicine Theses -- Medicine Dissertations -- Obstetrics and gynaecology Theses -- Obstetrics and gynaecology Raja, Kimenthra The influence of sex chromosomes on the outcome of human embryo development |
| title | The influence of sex chromosomes on the outcome of human embryo development |
| title_full | The influence of sex chromosomes on the outcome of human embryo development |
| title_fullStr | The influence of sex chromosomes on the outcome of human embryo development |
| title_full_unstemmed | The influence of sex chromosomes on the outcome of human embryo development |
| title_short | The influence of sex chromosomes on the outcome of human embryo development |
| title_sort | influence of sex chromosomes on the outcome of human embryo development |
| topic | Human reproduction Conception Human embryo Sex chromosomes Dissertations -- Medicine Theses -- Medicine Dissertations -- Obstetrics and gynaecology Theses -- Obstetrics and gynaecology |
| url | http://hdl.handle.net/10019.1/2378 |
| work_keys_str_mv | AT rajakimenthra theinfluenceofsexchromosomesontheoutcomeofhumanembryodevelopment AT rajakimenthra influenceofsexchromosomesontheoutcomeofhumanembryodevelopment |