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An investigation of the role of phosphorylation at Ser211 of the glucocorticoid receptor in ligand-specific transcriptional regulation
Thesis (MSc (Biochemistry))--University of Stellenbosch, 2005.
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Stellenbosch : University of Stellenbosch
2006
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| _version_ | 1867613738101637120 |
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| access_status_str | Open Access |
| author | Stubsrud, Elisabeth |
| author2 | Hapgood, J. P. |
| author_browse | Hapgood, J. P. Stubsrud, Elisabeth |
| author_facet | Hapgood, J. P. Stubsrud, Elisabeth |
| author_sort | Stubsrud, Elisabeth |
| collection | Thesis |
| dc_rights_str_mv | University of Stellenbosch |
| description | Thesis (MSc (Biochemistry))--University of Stellenbosch, 2005. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/2497 |
| institution | Stellenbosch University (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:40:54.953Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2006 |
| publishDateRange | 2006 |
| publishDateSort | 2006 |
| publisher | Stellenbosch : University of Stellenbosch |
| publisherStr | Stellenbosch : University of Stellenbosch |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/2497 An investigation of the role of phosphorylation at Ser211 of the glucocorticoid receptor in ligand-specific transcriptional regulation Stubsrud, Elisabeth Hapgood, J. P. Louw, A. Ronacher, K. University of Stellenbosch. Faculty of Science. Dept. of Biochemistry. Dissertations -- Biochemistry Theses -- Biochemistry Phosphorylation Glucocorticoids -- Therapeutic use Ligands (Biochemistry) Gene expression Thesis (MSc (Biochemistry))--University of Stellenbosch, 2005. Endogenous glucocorticoids (GCs) modulate many physiological functions in the human body and synthetic GCs are the most effective therapy in the treatment of inflammation, autoimmune and endocrine disorders. However, the long-term usage of synthetic GCs is associated with severe side-effects. GCs mediate their effects through the ligand-dependent transcription factor, the glucocorticoid receptor (GR), either by causing an increase (transactivation) or a decrease (transrepression) in gene transcription. The bioactivity of a ligand in GR-mediated transcriptional regulation is established by a transcriptional doseresponse curve, where the potency (EC50 value) and the efficacy (maximal response) of the ligand are determined. A central question is how different GR ligands elicit their differential physiological responses for the same gene in the same cell. The main aim of this thesis is to investigate if the phosphorylation of GR at serine 211 (Ser211) correlates with the potency and/or efficacy of a particular ligand in transactivation and transrepression of gene expression. 2006-11-15T09:23:35Z 2010-06-01T08:50:18Z 2006-11-15T09:23:35Z 2010-06-01T08:50:18Z 2005-12 Thesis http://hdl.handle.net/10019.1/2497 en University of Stellenbosch 1325038 bytes application/pdf application/pdf Stellenbosch : University of Stellenbosch |
| spellingShingle | Dissertations -- Biochemistry Theses -- Biochemistry Phosphorylation Glucocorticoids -- Therapeutic use Ligands (Biochemistry) Gene expression Stubsrud, Elisabeth An investigation of the role of phosphorylation at Ser211 of the glucocorticoid receptor in ligand-specific transcriptional regulation |
| title | An investigation of the role of phosphorylation at Ser211 of the glucocorticoid receptor in ligand-specific transcriptional regulation |
| title_full | An investigation of the role of phosphorylation at Ser211 of the glucocorticoid receptor in ligand-specific transcriptional regulation |
| title_fullStr | An investigation of the role of phosphorylation at Ser211 of the glucocorticoid receptor in ligand-specific transcriptional regulation |
| title_full_unstemmed | An investigation of the role of phosphorylation at Ser211 of the glucocorticoid receptor in ligand-specific transcriptional regulation |
| title_short | An investigation of the role of phosphorylation at Ser211 of the glucocorticoid receptor in ligand-specific transcriptional regulation |
| title_sort | investigation of the role of phosphorylation at ser211 of the glucocorticoid receptor in ligand specific transcriptional regulation |
| topic | Dissertations -- Biochemistry Theses -- Biochemistry Phosphorylation Glucocorticoids -- Therapeutic use Ligands (Biochemistry) Gene expression |
| url | http://hdl.handle.net/10019.1/2497 |
| work_keys_str_mv | AT stubsrudelisabeth aninvestigationoftheroleofphosphorylationatser211oftheglucocorticoidreceptorinligandspecifictranscriptionalregulation AT stubsrudelisabeth investigationoftheroleofphosphorylationatser211oftheglucocorticoidreceptorinligandspecifictranscriptionalregulation |