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Mutation screening of pre-eclampsia candidate genes, LEP (ob) and LEPR (obR)
Thesis (MSc (Genetics))--University of Stellenbosch, 2006.
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| Format: | Thesis |
| Language: | English |
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Stellenbosch : University of Stellenbosch
2006
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| _version_ | 1867613772462424064 |
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| access_status_str | Open Access |
| author | Hoek, Kim G. P. |
| author2 | Hillermann-Rebello, R. |
| author_browse | Hillermann-Rebello, R. Hoek, Kim G. P. |
| author_facet | Hillermann-Rebello, R. Hoek, Kim G. P. |
| author_sort | Hoek, Kim G. P. |
| collection | Thesis |
| dc_rights_str_mv | University of Stellenbosch |
| description | Thesis (MSc (Genetics))--University of Stellenbosch, 2006. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/2834 |
| institution | Stellenbosch University (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:41:26.849Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2006 |
| publishDateRange | 2006 |
| publishDateSort | 2006 |
| publisher | Stellenbosch : University of Stellenbosch |
| publisherStr | Stellenbosch : University of Stellenbosch |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/2834 Mutation screening of pre-eclampsia candidate genes, LEP (ob) and LEPR (obR) Hoek, Kim G. P. Hillermann-Rebello, R. Gebhardt, G. S. University of Stellenbosch. Faculty of Agrisciences. Dept. of Genetics. Dissertations -- Genetics Theses -- Genetics Preeclampsia -- Genetic aspects Leptin Genetic disorders in pregnancy Pregnancy -- Complications Thesis (MSc (Genetics))--University of Stellenbosch, 2006. Pre-eclampsia is a multisystemic disorder with an incidence of ~6-8% in non-Caucasian women in the Western Cape. Trophoblast invasion is vital for adequate anchorage of the placenta to the uterine wall as well as for the optimisation of utero-placental blood flow in uncomplicated pregnancies. This process is facilitated by the fetal trophoblast cells that digest the extracellular matrix of the uterus by secreting various molecules, including the metalloproteinases (MMP), of which MMP-9 has an increased production during the first trimester. Leptin, an autocrine regulator of MMP-9 secretion, functions via the leptin receptor to prevent over-invasion of maternal tissues. The aim of this study was to investigate the role of the leptin (ob) and leptin receptor (obR) genes in predisposition to pre-eclampsia and involved screening the genes in South African non-Caucasian cohorts and performing statistical analysis to determine whether any variants contributed to the disease profile. Masters 2006-11-10T06:27:41Z 2010-06-01T08:59:33Z 2006-11-10T06:27:41Z 2010-06-01T08:59:33Z 2006-03 Thesis http://hdl.handle.net/10019.1/2834 en University of Stellenbosch 592027 bytes 780021 bytes 212525 bytes application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf Stellenbosch : University of Stellenbosch |
| spellingShingle | Dissertations -- Genetics Theses -- Genetics Preeclampsia -- Genetic aspects Leptin Genetic disorders in pregnancy Pregnancy -- Complications Hoek, Kim G. P. Mutation screening of pre-eclampsia candidate genes, LEP (ob) and LEPR (obR) |
| title | Mutation screening of pre-eclampsia candidate genes, LEP (ob) and LEPR (obR) |
| title_full | Mutation screening of pre-eclampsia candidate genes, LEP (ob) and LEPR (obR) |
| title_fullStr | Mutation screening of pre-eclampsia candidate genes, LEP (ob) and LEPR (obR) |
| title_full_unstemmed | Mutation screening of pre-eclampsia candidate genes, LEP (ob) and LEPR (obR) |
| title_short | Mutation screening of pre-eclampsia candidate genes, LEP (ob) and LEPR (obR) |
| title_sort | mutation screening of pre eclampsia candidate genes lep ob and lepr obr |
| topic | Dissertations -- Genetics Theses -- Genetics Preeclampsia -- Genetic aspects Leptin Genetic disorders in pregnancy Pregnancy -- Complications |
| url | http://hdl.handle.net/10019.1/2834 |
| work_keys_str_mv | AT hoekkimgp mutationscreeningofpreeclampsiacandidategeneslepobandleprobr |